Michigan Medicine asks, What is the Most Important Occupation of Your Life? University of Michigan is grading Occupations of people without disclosing its Research Protocol

Excerpt: The Michigan Medicine AHEAD study is examining the efficacy of a medication aimed at preventing Alzheimer’s Disease in individuals at increased risk of developing the disease. The study has, however, faced criticism regarding its focus on years of schooling and its lack of a research protocol to verify the identity and individuality of the human organism. Critics assert that biological processes like the flow of biological information and protein synthesis are not influenced by education level and that individuality should not be tied to factors such as race and ethnicity. The conceptualization of “life as knowledge in action” and that it is an interplay of cellular function and knowledge must be explored.

The AHEAD Study is researching the safety and effectiveness of an investigational medication in people who might be at increased risk for developing memory loss associated with Alzheimer’s Disease. The study is looking for participants age 55-80 years old, who have generally normal memory function in daily life, and who are not being treated for memory problems. For individuals age 55-64 years old, an additional risk factor is required, such as a parent or sibling with Alzheimer’s Disease or previous biomarker testing showing increased risk for developing Alzheimer’s Disease. This study sees participants in Ann Arbor. Contact Lauren Mackenzie at spearsl@med.umich.edu or 734-232-2415.

On Tuesday, December 05, 2023, at the Michigan Clinical Research Unit (MCRU) at the Cardiovascular Center (CVC), I was interviewed for participating in the AHEAD Study and I completed the Stage 1A of the Screening process. I am asked to provide information about the most important occupation of my life, my sexual orientation, my race and ethnicity in the context of my place of birth and the country of origin, the total number of years I spent in the School to register my personal identity for participation in the Medical Research Project. The Research Protocol has not identified the basis for discovering the identity of a multicellular human organism. I can answer the questions I am asked. Do I have the ability to communicate my answers to the cells of my own body and reflect that identity in the living functions they perform to keep me alive?

Michigan Medicine may not understand the concept of Dignity of Labor and the Research protocol fails to provide a yardstick to measure the importance of any given human occupation. I claimed that the occupation of Grocery Clerk at Whole Foods is the most important occupation of my life for it gives me the opportunity to share my concept of Whole Spirituality which accounts for the physiological basis of my human existence.

The Rudolf-Rudi Connection formulates a Theory of Human Existence that refutes the doctrine of Existentialism

Yes indeed, Life is complicated. The complexities of Life involve knowing What You Are (Essence) and What You Do (Existence). But, Existence precedes Essence.

What it is to be a Substance? and What it is to Exist? We need to establish knowledge about the man on a firm basis and the information it provides must be tested for its accuracy and consistency with an external reality. We have to make the fundamental distinction between the living and the non-living matter. The scientific advances of the 19th and 20th centuries reinforced the materialistic position concerning the basic similarity of organic living and inorganic physical matter. The man is viewed as a product of natural evolution and is thought to be subject to the same laws of Physics and Chemistry or mechanistic principles.

We need a methodology to study philosophy and to understand philosophical statements. Logical Positivism, also known as Scientific Empiricism aims to clarify concepts in both everyday and scientific language. It describes analysis of language as the function of philosophy. This analysis of language and of concepts is important to understand questions of belief and ideology which affect what we think we ought to do individually and socially. I use this method of ‘Applied Philosophy’ to analyze the philosophical doctrine of ‘Existentialism’ and to study the views and philosophy of Jean Paul Sartre and his efforts to interpret the human nature and the human existence.

What is man? The motivation for asking this question comes from a statement expressed in Sanskrit language, “Sarvesham Swastir Bhavatu”, which seeks the well-being of all humans, of all races, of all religions, of all cultures, and of all nations. Our efforts to support the well-being of man would be affected by our understanding the ‘real’ or ‘true’ nature of man. All human traditions, including religious, cultural, literary, philosophical, and scientific traditions make assumptions about human nature. The basic assumption about human nature is that of finding it displayed in thoughts, feelings, moods, and the actions and the behaviors that proceed from such mental states of the human individual.

I ask my readers to discover Human nature by understanding the biological basis for human existence. Human nature is a reflection of that potency that keeps the human object existing. To describe human nature from mental life or mental states of an individual causes Subject-Object Dualism. I try to know human nature by knowing the characteristics of the substance that exists. The substance when it performs its functions, the characteristics of its behavior could be observed in biotic interactions, the interactions of the cells, the tissues, the organs and the organ systems that constitute the human organism. I try to discover human nature of a subject who objectively exists because of the functions of the cells, the tissues, organs and organ systems that provide the basis for that existence.

Existentialism – The Philosophy of Human Existence:

The philosophical focus of Existentialism is concerned with the uniqueness of the individual human being, the meaning or purpose of human life as a subjective experience, and with the freedom of human individual. Sartre believed in the ability of every person to choose for himself his attitudes, purposes, values, and a way of life. Sartre’s thesis is that humans are essentially free, free to choose (though not free not to choose) and free to negate the given features of the world. In his novel, “Being and Nothingness” (1943), Sartre expresses an opinion that the only ‘authentic’ and genuine way of life is that freely chosen by each individual for himself. Sartre’s driving belief in Radical Freedom involves the ability to choose not only a course of action but also what one would become. According to Sartre, man is truly free, the world, whether material or social can place no constraints on him, not even to the extent of determining what would or would not be good reasons for following a given course of action. Sartre thought that there are no transcendent or objective values set for human beings and that there is no ultimate meaning or purpose inherent in human life. Sartre insists that the only foundation for values is human freedom and that there can be no external or objective justification for the values anyone chooses to adopt.

Human Consciousness and Human Existence:

Sartre makes a radical distinction between consciousness (L’etre-pour- soi, being-for-itself) and non-conscious objects (L’etre-en-soi, being-in-itself). Though it is correct that human beings have emotional feelings, thoughts, and moods, the nature of consciousness is the same in all living entities. The presence or absence of feelings is of no consideration to make the fundamental  distinction between inanimate and animate beings. He focused on the opposition between objective things and human consciousness. This basic dualism is shown by the fact that consciousness necessarily has an object; it is always consciousness of something which is not itself. Consciousness makes the distinction between itself and its object. Sartre makes a conceptual connection between consciousness and nothingness. Human consciousness is a non-thing as its reality consists in standing back from things and taking a point of view on them. Because consciousness is a non-thing (Sartre’s “neant” literally means “nothingness”), it does not have any of the causal involvements that things have with other things. This means that consciousness and thus humans themselves are essentially free. In Sartre’s view, to pretend that we are not free is that of self-deception or bad faith (mauvaise foi). According to Sartre, the freedom of human consciousness is experienced by humans as a burden and it causes anguish. Sartre’s most basic point is that to be conscious is to be ‘free’.

In my view, the physiological function called consciousness primarily involves the awareness of my own energy dependent existence at a given particular time and place. In other words, I am Conscious for I know that I am not Free. Sartre’s concept of human freedom is a simple mental entity and it involves the freedom of imagination. However, man has a very limited freedom to convert his imagination into an external actuality. The man lacks total freedom and has no true freedom as he does not directly rule or govern even a single cell in his body which comprises of trillions of individual living cells which have functional autonomy and are independent entities while being part of a group.

Human Consciousness and Human Freedom:

I disagree with the view shared by Sartre and various others about the nature of human consciousness. The problem involves the description of consciousness as a mental function. Consciousness is a neurobiological function, and more importantly it is the basic living function. The living cell is aware or conscious of the fact of its own existence, it is conscious of itself and its internal condition, and it is conscious of its external environment and objects found in its external environment. Hence, consciousness must be described as a biological characteristic of living cells and living organisms. Consciousness describes the nature of the substance that is living, the matter that lives and is known as living matter. The living matter is conscious of its internal condition, a condition that demands the supply of energy from an external source to keep its existence. The biological properties of motion, and nutrition come into play because of this biological characteristic called consciousness. Hence it is a vital, or animating principle of all living cells and living organisms. The living cell because of its consciousness knows its nature of energy dependent existence and uses its power of motion and nutrition to attract substances found in its external environment to perform all other living functions to support its growth and maintenance. The fact of energy dependent existence and the consciousness of that conditioned existence displays the lack of human freedom in matters that pertain to human existence. A complex human living system exists because of harmonious interactions, partnership, relationship, and association between the cells, the tissues, the organs, and the organ systems that constitute the human individual. These biotic interactions display behavioral characteristics such as mutual assistance, mutual cooperation, mutual tolerance, mutual subservience, mutual functional subordination to provide benefits to each other to support the survival and reproductive success of each other. There is sympathy, compassion, and understanding for the needs of each other, the participants of a biotic or biological community or association of living cells that comprise the human person.

I observe the human organism and I can accurately describe that Spiritualism is the chief attribute of human existence and human nature. The man has no freedom and the man has no choice other than that of existing as a Spiritual Being. It is ironic that the man has no cortical or mental awareness of the spiritual nature of his own body and the substance that lives because of its nature. By seeking awareness of the underlying spiritual nature, the man will be able to live in harmony and peace within himself and with others in his environment. I agree with the view of Sartre and suggest that man’s existence precedes his essence. Sartre has failed to contemplate upon the biological basis of human existence and hence could not describe the reality of human essence and human nature. The Subjective Reality of physical existence precedes and defines the nature of human being. Who you are (your Essence) is defined by what you do (your Existence). To know the man’s essence, to describe the human nature, we need a man who is existing. If there is no living, physical being called man, it would serve us no purpose to know its nature or essence. In Spiritualism, the man’s essence and existence come together to establish the purpose of man in Life.

THE ART OF RECEIVING AND THE ART OF GIVING:

Sir Winston Churchill said, “You make a living by what you get. You make a life by what you give.” To add clarity to this quote, I would like to say that human existence depends upon receiving energy from an external source. Human nature involves sharing that energy with others. The human person comprises of about 100 trillion individual, living cells and at the same time there are about 10 times 100 trillion microorganisms that inhabit the human gastrointestinal tract. There is a mutually beneficial relationship between man the host and the microbes that inhabit the gastrointestinal tract. These microbes receive a fair share of energy and material that man consumes as food and drink. This relationship persists during the entire course of man’s life. If receiving is inescapable, giving is inevitable consequence of human living and human life. Spiritualism is the potency that gives the man the ability to Receive and to Give to others. 

Simon Cyrene

Rudolf is reborn as Rudi to describe the spiritual connection between the Cell and its Energy Provider

Rudi acknowledges his German heritage at Whole Foods when he discovered the spiritual connection between man, food, and Providence.

Whole Foods, Whole People, and Whole Planet are connected by a material substance called Protoplasm or Cytoplasm, a divine plan to provide nourishment to Life.

The Rudolf and Rudi Connection at Whole Foods, Ann Arbor can be best described as the concept of Whole Spirituality, the three dimensional spiritual relationship between the multicellular human organism, food, and the Divine Providence.

Spiritualism – The Cell Theory of Spirituality:

In Biology, cell is the basic or fundamental unit of structure, function, and organization in all living things or it is the building block of life. Let me begin with my respectful tribute to some of the people who contributed to ‘The Cell Theory’, one of the foundations of Biological Sciences. Cells were first observed in the 17th century shortly after the discovery of the microscope. Robert Hooke, british curator of instruments at The Royal Society of London, during 1665 coined the word cell. Dutch microscopist Antonie Van Leeuwenhoek (1632-1723) made over 247 microscopes and examined microorganisms and tissue samples. He gave the first complete descriptions of bacteria, protozoa (which he called animalcules), spermatozoa, and striped muscle. He also studied capillary circulation and observed Red Blood Cells.

Improvements in microscopy during early 19th century permitted closer observation and the significance of cells had received better understanding. Matthias Jakob Schleiden (1838), German botanist, Theodor Schwann (1839), German physiologist, and Rudolf Virchow (1855), German pathologist, and others made important contributions to the Cell Theory that describes cell as the building block of all Life.

The Cell is the smallest unit in the living organism that is capable of carrying on the essential life processes of sustaining metabolism for producing energy and reproducing. Many simple, small, single-celled organisms like Protozoa perform all life functions. In higher, complex, bigger, multicellular organisms, groups of cells are structurally and functionally differentiated into specialized tissues and organ systems. Thus, the Cell Theory includes the following foundational principles of the Biological Sciences:

1. All living things are made up of cells. Cell is the most elementary or basic unit of Life. 

2. Cell is a fundamental unit of structure, function, and organization in all living things including plants and animals.

3. Cells only rise from division of previously existing cells.

4. All cells are similar in composition, form, and function. All cells are basically the same in chemical composition (in spite of variations) in organisms of similar species. For example, all the solid tissues in the human body can be shown to consist largely of similar cells; differing it is true, but that are essentially similar to an Ovum.

5. The cells exhibit functional autonomy. The activity of an organism depends on the total activity of ‘INDEPENDENT’ cells.

6. Energy flow (metabolism and biochemistry) occurs within cells.

7. Cells contain hereditary, biological information (DNA) which is passed from cell to cell during cell division.

The Cell Theory of Spirituality:

The basic or fundamental unit of life in the human organism is derived from the fertilized egg cell that eventually develops into a complete organism. The most significant feature of similarity between the cells of the human body is the presence of a soft, gelatinous, semi-fluid, granular material inside the cell. This substance known as Protoplasm or Cytoplasm, or Cytosol is similar to the ground substance found in the Ovum or the Egg Cell.

This viscous, translucent, colloidal substance is enclosed in a membrane called Cell Membrane, Plasma Membrane or Biological Membrane. A small spherical body called nucleus is embedded in the Protoplasm of the cell. The three essential features of any living cell in the human body are that of the presence of protoplasm, the nucleus, and the cell membrane.

Protoplasm – The Ground Substance of Spiritualism and Spirituality:

I seek the existence of Soul or Spirit in a substance that is basic to life activities, and in a material that is responsible for all living processes. I, therefore, propose that the understanding of the true or real nature of this ground substance of all living matter will help man to discover peace, harmony, and tranquility in all of his internal and external relationships while man exists in a physical environment as a member of a social group, social community, and Society. In this blog post, I would like to pay my respectful tribute to Jan Evangelista Purkinje and Hugo Von Mohl for their great contribution to the scientific understanding of the living substance, living material, and living matter.

Purkinje conducted his research on human vision at the University of Prague and later on, he served there as a Professor of Physiology (1850-69). He went to Germany and was appointed the Chair of Physiology and Pathology (1823-50) at the University of Breslau, Prussia. There Purkinje created the world’s first independent Department of Physiology (1839) and the first Physiological Laboratory (Physiological Institute, 1842). He is best known for his discovery of large nerve cells with many branching extensions found in the cortex of Cerebellum of the brain (Purkinje Cells, 1837). He discovered the fibrous tissue that conducts electrical impulses from the ‘pacemaker’ called Atrioventricular node or A-V node along the inside walls of the ventricles to all parts of the heart to help in Cardiac contractile function (Purkinje Fibers, 1839). In 1835, he invented and introduced the scientific term ‘Protoplasm’ to describe the ground substance found inside young animal embryo cells. He discovered the sweat glands of the skin (1833); he discovered the nine configuration groups of Fingerprints used in biometric identification of man (1823); he described the germinal vesicle or nucleus of the unripe ovum that now bears his name (1825), and he noted the protein digesting power of pancreatic extracts (1836).

Hugo Von Mohl named the granular, colloidal material that made up the main substance of the plant cell as “Protoplasm” in 1846. Purkinje invented the word, but Hugo gave more clarity, understanding, and knowing the nature of this ground substance. He viewed cell as an “elementary organ” and in Physiology he explained Protoplasm as an organ of Motion or Movement, Nutrition, and Reproduction. It is the preliminary material in cellular generation. He was the first to propose that new cells are formed by division of preexisting cells and he had observed this process of Cell Division in the algal cells of Conferva glomerata. His observations are very important to understand the Cell Theory that explains cells as the basic building blocks of Life. He was the first to investigate the phenomenon of the stomatal openings in leaves.

Protoplasm is a complex, viscous, translucent solution of such materials as salts and simple sugars with other molecules, mostly proteins and fats, in a colloidal state, that is dispersed but not dissolved in one another. Carbon, Hydrogen, Oxygen, and Nitrogen constitute more than 90 percent of Protoplasm.

It exhibits properties such as Protoplasmic Streaming or Cytoplasmic Streaming or Motion that is called “Amoeboid Movement.” It has the intrinsic power to change its shape and position.

Protoplasm has the power of Nutrition by which it can attract and obtain the materials necessary for its growth and maintenance from surrounding matter/environment.

The living functions such as Nutrition, Cellular Respiration, and Reproduction performed by Cytoplasm involve acquiring, processing, retaining, and using information to perform tasks in a sequential manner for a predetermined purpose and hence describe Consciousness, Memory, and Intelligence.

The terms Soul and Spirit belong to the materialistic realm where the Physical Reality of man’s biological existence is established. I have not yet discovered any good reason to use the terms Soul and Spirit as a metaphysical or transcendental Reality.

The Inheritance of Cytoplasmic Membrane or Cell or Plasma Membrane:

The Functions of Cytoplasmic Membrane or Cell Membrane or Biological Membrane:

1. Protection: It protects the cell from its surroundings or extracellular environment. Plant cell possess wall over the plasma membrane for extra protection and support. 

2. Holding cell contents: Plasma membranes hold the semi fluid protoplasmic contents of the cell intact; thus keeping the individuality of the cell.

3. Selective Permeability: Cell membrane allows only selected or specific substances to enter into the cell and are impermeable to others. 

• Gases like O₂ and CO₂ can diffuse rapidly in solution through membranes.
• Small compounds like H2O and methane can easily pass through where as sugars, amino acids and charged ions are transported with the help of transport proteins.
• The size of the molecules which can pass through the plasma membrane is 1-15 A⁰. This property is responsible for keeping a cell ‘as a cell’, an individual unit. 

4. Shape: It maintains form and shape of the cell. It serves as site of anchorage or attachment of the cytoskeleton; thus providing shape to the cell (especially in animal cells without cell wall). 

5. Organelles: Cell membrane delimits or covers all sub-cellular structures or organelles like nucleus, mitochondria, plastids, Golgi apparatus, endoplasmic reticulum, microbodies etc. thus protecting them form the surroundings and also helps in maintaining a constant internal environment.

6. Compartmentalization: Cell membrane separate the cells from their external environment and cell organelle from cytosol. It help the cells and their organelles to have their own microenvironments, structural and functional individuality. 

7. Cell Recognition: With the help of glycolipids and glycoproteins on its surface, cell membranes are able to differentiate similar cells from dissimilar ones, foreign substances and cells own materials. Cell recognition is useful for tissue formation and defence against microbes. 

8. Antigens: Cell membranes possess antigens which determine blood grouping, immune response, acceptance or rejection of a transplant (graft rejection by MHC’s on plasma membrane). 

9. Microvilli: They are microscopic finger like projections of plasma membrane present on some cells like intestinal epithelial cells, which are involved in a wide variety of functions, including increasing surface area for absorption, secretion, cellular adhesion etc.

10. Sheaths of cilia and flagella: Cilia and flagella are projections from the cell; made up of microtubules which are covered by an extension of the plasma membrane.

11. Cytoplasmic bridges in plasmodesmata and gap junctions: Plasmodesmata in plant cells and gap junctions in animal cells; meant for intercellular transport and communication, form cytoplasmic bridges between adjacent cells through plasma membrane.

12. Endocytosis and Exocytosis: Bulk intake of materials or endocytosis occurs through development of membrane vesicles or invagination and engulfing by plasma membrane.

Exocytosis: It is reverse of endocytosis that provides for releasing waste products and secretory materials ot of the cells with the help of plasma membrane. 

13. Impulse transmission in neurons: The transmission of a nerve impulse along a neuron from one end to the other occurs as a result of electrical changes across the plasma membrane of the neuron

14. Cell metabolism: Cell membranes control cell metabolism through selective permeability and retentivity of substances in a cell. 

15. Electron transport chain in bacteria: In bacteria; Electron transport chain is located in cell membrane.

16. Osmosis through cell membrane: It is movement of solvent molecules (generally water) from the region of less concentrated solution to the region of high concentrated solution through a semi permeable membrane. Here the semi permeable membrane that helps in osmosis is the cell membrane. Eg: Root cells take up water from the soil by osmosis 

17. Carrier proteins for active transport: They occur in the cell membranes and control active transport of substances. Example, GLUT1 is a named carrier protein found in almost all animal cell membranes that transports glucose across the bilayer or plasma membrane.

18. Plasma Membrane enzymes: Many enzymes are present on the plasma membrane with wide variety of catalytic activity. Example: Red blood cell plasma membranes contain a number of enzymes such as ATPases, anion transport protein, glyceraldehyde 3-phosphate dehydrogenase, protein kinases, adenylate cyclase, acetylcholinesterase.

19. Cell Membrane Receptors: Receptor on the plasma membrane performs signal transduction, converting an extracellular signal into an intra-cellular signal. Membrane possess receptors for hormones, neurotransmitters, antibodies and several other biochemicals.

20. Plasma membrane assisted Cell movements: Undulation and pseudopodia are cell membrane phenomenon involved in cell movement. Amoeba, macrophages and WBCs move with the helps of temporary organelles like pseudopodia. Pseudopods are temporary cytoplasmic projections of the cell membrane in certain unicellular protists such as Amoeba. Some mammalian cells such as fibroblasts can move over a solid surface by wave like undulations of the plasma membrane.

The Ground Substance of Spiritualism and Spirituality. The vital characteristics, the animating principles of Protoplasm could be known by observing Amoeba proteus. The Living Substance works as an organ of Motion or Movement, as an organ of Nutrition, and as an organ of Reproduction to generate new cells which have a life span of their own. In these physiological functions, I describe the characteristics such as Cognition, Consciousness, Memory, and Intelligence as spiritual attributes of Life as they bring functional unity and harmony in the interactions between different parts of the same individual organism while it exists in an environment as a member of a biological community.

The Spirituality of Substance, Function, Organization, Action, and Interactions:

To establish the biological existence of the human organism, I add the concept of Spiritualism and Spirituality to the Cell Theory.

The Single Fertilized Egg Cell has ground substance that is of Spiritual nature and the Spiritualism and Spirituality consists of the following functional, and organizational characteristics:

1. The Cell is Conscious of its own existence and knows its internal condition and knows it external environment.

2. The Cell is intelligent and it has the cognitive abilities like perception and memory to acquire information, to retain information, to recall information, and to use information in the performance of its complex tasks in a sequential manner.

3. The Cell has the ability to show characteristics such as mutual cooperation, mutual tolerance, and display functional subordination and subservience while being independent.

4. The Cell grows, divides, and develops into a complete organism while it acquires substances and energy from an external environment. The power of Protoplasm/Cytoplasm to attract matter found in its external environment is called Nutrition. The Cell continuously transforms matter to build matter of its own kind for its own benefit to sustain its  existence with its own identity and individuality. The Organism represents a social group or a biological community of Cells. The Spiritual nature of Protoplasm/Cytoplasm brings this functional harmony and unity in the Social Group or Biotic Community of Cells by bringing together its Essence and Existence.

5. The Cell Theory is incomplete for it does not describe the conditioned nature of the Cell’s existence. The Cell represents a Living System that is thermodynamically unstable. It requires a constant supply of matter and energy from its external environment to sustain its living functions. The concept of Whole Spirituality formulates the connection between the Cell and its external source of matter and energy.

The theoretical claims about Spirit and Soul, the religious and philosophical doctrines of Spiritualism and Spirituality must be verified using the Cell Theory that defines the human organism. To describe Soul or Spirit as  nonmaterial or immaterial Self will not help man to know the real or true man.

Simon Cyrene

Whole Foods, Whole People, and Whole Planet come together in a Wholesome Relationship as God is the Energy Provider, the Original Source of Matter and Energy for Life.