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The Rudolf Virchow Doctrine of Whole Spirituality

Yes indeed, Life is Complicated because we still do not know many things about Life. We need to discover the nature of Interactions that operate the Connection between Whole Foods, Whole People, and Whole Planet. I coined the phrase Spiritual Interactions to account for the Physiological Basis of Life. But, I need to Live One More Day to learn about the term Biotic Interactions.

The objective of this presentation is to define ‘Spiritualism’ as an internal, mutually beneficial partnership, relationship, association, or bonding between individual living cells of the same organism, or between two different organisms. Spiritualism has to be explained in the context of biotic interactions and consciousness determines the nature and characteristics of such biotic interactions.

 Dr. Heinrich Anton de Bary had coined the term ‘Symbiosis’ in 1879. It describes the living together of unlike organisms; the intimate association of two dissimilar organisms from which each organism benefits. Symbiosis (sym – together; bios – life) refers to various kinds of close and permanent associations between members of different species and the term could also be used to describe the nature of social relations between different human beings.

 What is a Biotic Community? 

A biotic community is a biological or natural community consisting of two or more interacting and interdependent populations of living cells or living organisms. No species, and no individual member lives in isolation from other species or other living members in a biological community. The life of the community and of all its members, and of all organisms in it requires energy.

No Man is an Island, Entire of Itself:

Ernest Hemingway’s novel “For Whom The Bell Tolls” gives this modern version of the quote from John Donne’s Meditation XVII, “Devotion Upon Emergent Occasions” : “No man is an island, entire of itself; every man is a piece of the continent a part of the main.” In this blog post I would like to examine the biological basis for human existence and understand the nature of man and the status of man as an organism existing at a given place, and given environment because of mutually beneficial biotic interactions.

What are Biotic Interactions? 

Living organisms interact with each other competitively and sometimes beneficially. Some of these interactions are temporary, casual and of minor importance whereas others are permanent, vital and of major significance. Many interactions are highly specialized and complicated involving adaptive changes in structure, function, behavior, and ecology. Some interactions create negative effects on the interactants, reducing survival or reproductive success; other interactions produce effects increasing survival or reproductive success. In some cases, members of an interaction are apparently unaffected. Biotic interactions could be divided into two categories; a. Intraspecific Interactions; interactions between the individual living cells that comprise the same multicellular orgainsm, or interactions between members of the same species, and b. Interspecific Interactions; interactions between members of two or more different species.

The biotic interactions may involve nutritional benefits, support of other metabolic functions, space in which to live, shelter, or protection, transport, or reproductive capability. Biotic interactions are significant not only because they influence individual species but also because they constitute the principal stabilizing, connective linkages among the various species contained in a biotic community. Individual members of any given species in a biological community persist in relative harmony because of biotic interactions despite individual gains and losses. As a consequence of this web of interactions, the biotic community as a whole persists with all of its members ultimately contributing to its continuation. The consequences of biotic interactions could be positive, negative, or neutral.

Mutualism is an association of two different species that result in mutual benefit or gain. Facultative Mutualism or Protocooperation involves facultative interactions between plants and animals in ways that are general and indirect but beneficial to both species. The interactions that occur between soil bacteria and fungi and between them and higher plants growing in the soil are Protocooperative. In the zone of plant roots, soil bacteria and fungi interact with each other, some producing nutrients or metabolites required by others and all obtaining nutrients ultimately from root exudates and decaying organic matter. Plants benefit from the actions of this microflora by acquiring needed minerals, and nitrogen compounds. The important association of nitrifying bacteria in the process called Nitrogen Fixation, the extraction of Nitrogen from the environment by the roots of leguminous plants is well-known. Collectively all microflora and higher plants, with associated soil fauna, participate in determining soil composition, soil structure, and soil fertility. Man exists in nature as a terrestrial organism because of these biotic interactions that transform the characteristics of soil and its ability to support life.

Biotic communities that are based on Obligative Mutualism are characterized by stable, persistent, and interdependent associations between species. Coexistence in a given habitat is always required as this association is mandatory for the survival of each participant. This kind of association is perpetrated from one generation to the next. To guarantee the coexistence of the partners, the species involved show relationships based upon structure, behavior, and life history. In lichens, the fungal member penetrates algal cells with feeding tubes or haustoria, thus effecting an intimate physical interconnection. This nutrient exchange helps the algal cells to develop resistance to drying or to extreme temperatures. 

Commensalism is an association in which one member benefits while the other remains unaffected. Physical Commensalism involves the need for living space and the examples are provided by woody plants that physically support numerous orchids and ferns. Nutritional Commensalism is well illustrated by the many organisms found in the alimentary tracts of man and other higher animals. Such microbial gut flora use host waste products for food and acquire water and a suitable climate in which to live. No harm is done to the hosts. 

In Parasitism, the smaller organism benefits at the expense of the larger organism. Both plants and animals are attacked by parasites. Many parasites cause disease and death of the host organism. Parasitism constitutes a considerable burden on a host population. Many disease causing organisms are parasites carried from host to host by some other organism; for example Malaria is caused by a protozoan parasite transmitted by mosquitoes. In such situations, the biotic interactions involve three necessarily coexisting species: the pathogen, the carrier or vector species, and the host. An intermediate host interposed between the target host and parasite adds ecological complications to host-parasite interactions: the parasite, host, and intermediate host must all be present in the same community in suitable numbers at the same time. 

Consumption describes organisms eating organims. It is the most important class of biotic interactions. Herbivory describes animals eating plants. Predation refers to a large or strong animal that consumes a small or weak animal. Scavengers eat or consume dead or decaying organisms and organic material. Consumption is the basic food association (trophic link) through which the composition dynamics and variation of biological community’s structure takes place. All organisms form links in the community food chains and food webs, the nutritional pathways characteristic of given biological community. 

Amensalism is an association between organisms of two different species in which one is inhibited or destroyed and the other is unaffected. There are two basic modes of Amensalism; 1. Competition occurs when two species utilize a common, limited resource such as food, space, and water, and in doing so, one species interferes with, injures, or deprives the other species. Competition may involve a larger or stronger organism that excludes a smaller or weaker one from living space or deprives it of food; Intraspecific Competition occurs when competitors are of the same species. Competitive interactions may lead to Competitive Exclusion or Competitive Displacement, and 2. Antibiosis, in which one organism is unaffected but the other is damaged or killed by a chemical secretion. The classic example of Antibiosis is the discovery of Penicillin antibiotic by Dr. Alexander Fleming who had observed that the bread mold Penicillium notatum had effects upon the growth of colonies of bacteria. Mutual Antagonism occurs when a biotic interaction between two species results in harm or death to both.

Interactions within a Species: The Role of Negative Interactions:

Intraspecific Competition provides the ultimate force limiting the abundance of a species in a community. Natural enemies could be present or absent but others of the same species are always present providing the Competition that insures against over exploitation of available resources and the irreversible destruction of a community due to overpopulation. Fighting and territorial defense are some of the overt methods by which Competition manifests itself. Territoriality, the dividng up of resources, mostly space, is a common means of defense against overcrowding. Instead of involving individuals against individuals, it involves groups of individuals. It also produces the response of migration of individuals and mass flight of large groups of individuals. Competitive Intraspecific Interactions between humans and Mutual Antagonism among human social groups may endanger human existence.

The Role of Positive Intraspecific Interactions:

The man’s life journey begins with conception and implantation of the embryo into maternal tissues about six days after conception. The prolonged period of gestation, the anatomical connection between developing fetus and mother, the psychological bonding and the extended period of dependence of newborn and the role of parental care reveal the importance of Positive Intraspecific Interactions for human existence. Numerous interactions among individuals of the same species lead to the development of social groups. Parental Care and protection provides the basis for many aggregations of like individuals, and social units like families.

Man’s Biological Existence as the Host of a Biotic Community:

The man exists in nature as a natural host to a biotic community of trillions of microorganisms. At birth, the stomach and gastrointestinal tract are usually sterile. With the first intake of food and contact with other humans present in the environment, bacteria commence the colonization of infant’s digestive tract. These microorganisms perform functions beneficial to the host. The microbes are provided with a protected place to live and their environment is rich in nutrients. This mutual, beneficial, symbiotic relationship is always present during the entire course of life after birth. The human body consists of about 100 trillion cells and it carries about ten times as many microbes in the intestines. The microbial flora include enteric bacteria, bacteroides, enterococci, lactobacilli, and clostridia. The small intestine contains low numbers of bacteria, about 100,000 to 10 million bacteria per milliliter of fluid. In the large intestine, the bacterial members can reach 100 billion per milliliter of fluid. It is estimated that these gut flora have around 100 times as many genes in aggregate as there are in the human genome. The metabolic activities performed by these bacteria resemble those of an internal organ of human body. The microbes are important to the health of humans. These bacteria are useful for efficient processing of food, absorption of water, absorption of nutrients like Magnesium, Calcium, and Iron. They perform a variety of useful functions such as synthesis of essential vitamins like Biotin, Vitamin K and production of short-chain fatty acids. The gut flora may produce hormones to direct the host to store fat. They train the host immune system to respond only to pathogens and thereby prevent the growth of harmful, pathogenic bacteria. They stimulate increased growth of human gut cells and also stimulate the growth of indigenous bacteria. Gut flora have enzymes that human cells lack for breaking down complex sugars called polysaccharides. The gut flora help in the digestion of unutilized energy substrates and may contribute upto 60 percent of the weight of the feces for human excretory function. Microbial flora of the gut can influence the phenomenon known as “Oral Tolerance” which may reduce an overactive immune response like those found in allergies and auto-immune disease. Gut flora play a major role in metabolizing dietary carcinogens and hence have a role in prevention of cancer. The human existence demands the play of these biotic interactions for its own benefit and for the benefit of the biotic community as its natural host.

Spiritualism – The Nature of Spiritual Interactions:

The term ‘spiritual’ describes the nature of a relationship, partnership, an association, or bonding between two living entities based upon the characteristics such as compassion, sympathy, cooperation, mutual assistance, tolerance, voluntary subservience, devotion, and functional subordination to provide some benefit to the members participating in the biotic interaction at a given place and in a given environment. Depending upon the size, complexity, and structure and functions of the Whole Organism, Spiritual Biotic Interactions and Spiritual Relationships are also based upon thoughts and feelings of sympathy and compassion that are attributes of mental functions and emotional makeup of the partners interacting. The Spiritual nature of biotic interactions is a reflection of the Spiritual nature of the Creator of the living entities who has provided the different modes of interactions using inspiration and imagination. Hence, Spiritualism as a biotic interaction describes an internal, mutually beneficial partnership between individual cells of the human organism and the Whole Organism that represents it as a Human Individual. 

The basic characteristic of a Living Cell or organism is the presence of consciousness. I recognize a cell as a Living Cell if it displays functions that characterize the presence of awareness or consciousness. The Living Cell or Living Object need not be aware or conscious of the Subject who may be investigating or observing the properties of the Object. The Living Object need to be aware of its own existence and its condition called Living. Atoms and molecules display their properties and interact according to the Laws of Physics and Chemistry. Living organic molecules show individualistic behaviors under experimental conditions that could be repeated and be verified. The Living Cell is very selective and it responds in a variable manner to physical and chemical stimuli. It can communicate or send signals to other Living Cells present in its environment. It responds according to its internal condition in relation to the environment in which it exists. The interactions of non-living physical matter are not goal-oriented. The interactions of Living matter are goal-oriented and they specifically achieve the purpose of sustaining, preserving, defending, and continuing the Living functions.

When does Life begins? When does Life ends? Every Living Cell is derived from a previously existing Living Cell. Life has not experienced the final event called Death. Life continues its act of Living through a function called Reproduction. A given species is considered to be totally extinct only if there is no surviving member to represent that particular species. Death is a programmed event and it gives meaning to the Identity of a Living Object. The dissolution of a single Living Object should not obscure the fact that Life is a continuous process. Life continues as Living Objects get new Identities. It is very reasonable to expect that Life would continue after the death of a given Living Object. People all over the world are a witness to that simple and direct observation. During the Life-Death continuum, the connection between the Creator and the created Living Object is manifested by the biological function called awareness or consciousness. The presence of Soul is evidenced by the presence of consciousness. As long as the Soul is functioning and is united with the physical being, the presence of consciousness could be detected and could be verified.

There has been no clearly defined and universally accepted metaphysical conception of the term Soul. It is a term rarely used with precise definition in philosophy, religion, or common life. In this discussion we face the problem of using words to which no definitive meaning is attached. If I make an attempt to define the word ‘God’, you may even speculate that I may belong to a new religious order. We need to come to a consensus even if an entity called ‘God’ does not exist. We need to formulate a view, a hypothetical view about Soul and test that hypothesis by countering it with a skeptical hypothesis. The Science called Physics deals with the properties, changes, interactions, etc. of matter and energy in which energy is considered to be continuous. In the ultimate analysis, matter is a representation of its energy content. The Science called Biology deals with Life and Life processes. While Life is made up of physical matter, Life processes are not explained by simple mechanistic interactions. However, I am willing to use the principles, the methods, and the tools used by Physics. Molecular Biology explains biological events by studying the molecules within cells; the molecular basis of genetics – Nucleic Acids and its relationship to energy cycling and replication. If this universe is seen as matter and energy, I would define God as the Controller of Force/Power/Energy. All living things are essentially made up of the same kind of living matter and yet they appear to be different. Life could be attributed to ONE common principle which has the ability to be simultaneously different. Each living object comes into a state of existence as a new object, as an original object, one of its own kind, unique, and distinctive. This morphological variation is an attribute of the organic molecules that establish the phenotype or the physical identity of that living organism. Physics provides those powerful tools to see the molecules and to recognize their individualistic behavior. Life comes into existence using a creative principle, and creative mechanisms that need inspiration, and imagination apart from the use of simple mechanistic laws. If Life is governed by the Law of Individuality, I would define God as a Creative Force/Power/Energy.

A majority of these life forms that we know and have studied, have synchronized their state of existence with an event that produces alternating periods of light and darkness while that source of light is not being turned ‘on’ and ‘off’. Rather we are forced to experience the effects of an illusion. Sunrise and Sunset is the reality that governs a majority of Biological Rhythms that control the life processes. Illusion is the necessary condition for the biological existence of Life. If Earth’s rotational spin generates this illusion, God uses Force/Power/Energy to cause illusion. In the universe that exists today, to the extent we have verified; there are no two identical celestial objects that exhibit the same rotational spin. In this context, it may be said that the Force/Power/Energy called God has created Earth to provide a home to the life forms that He has created as Individuals. These life forms have the ability called reproduction and yet lack the ability of producing two identical new objects. Sexual or Asexual reproduction always results in the production of new Individuals which could be easily verified by using the Biometric Identification Technology. Even the clones, sharing identical genomes, in reality exist as individuals. This Individuality when investigated by the tools supplied by Physics, it is discovered that the organic molecules such as the DNA molecules behave as Individuals and the man is not able to modify that behavior. Under the same experimental conditions, the DNA molecules behave as individuals. When we examine the nature of this biological existence, it indicates that life processes are supported by the provision of energy from an external source. The Living Cell is a thermodynamically unstable system. This means that without a continuous input of energy a Living Cell will degrade spontaneously into a nonliving collection of molecules. This lack of energy independence would direct us to define God as the Power/Force/Energy which delivers Compassion/Mercy/Grace which helps energy acquisition by energy dependent living organisms. Life forms on planet Earth exist depending upon an extraterrestrial source of energy or Cosmic Power/Force/Energy. Life exists because of its ability called ‘Association’. The act of associating, the state of being associated; the companionship, the fellowship, and the partnership is the defining feature of the State or Condition, or Act of Living. Association or partnership between energy seeker and energy provider could be described as God-Connection. Organisms that are single do not live as single cells but develop association with other single cells to form distinct Colonies. Organisms that are multicellular represent an organization of individual cells that are associated having common interests, purposes, sensations, etc., Since association has a purpose, in the context of biological existence, the association or connection, or partnership between the energy seeker, and the energy provider is a meaningful event and not a simple, mechanical, physical event governed by the Laws of Interactions between Matter and Energy. There are Four Fundamental Interactions and they do not regulate or define this Interaction between Living matter and the Cosmic Force/Power/Energy. Living matter uses and exploits energy in a creative manner to build organic molecules and to break down organic molecules. The life processes are very similar and yet the results are totally different. While using energy mostly following a similar metabolic pathway, each organism supports its identity and individuality.

Soul and Death:

The idea of ‘Soul’ always comes in the context of Death. If man is immortal, we will not be spending our time and energy to verify the existence of an immortal principle. The human subject has a limited life span and it arouses a sense of curiosity about the existence of something that could defy Death. I am trying to define the word ‘Soul’ in a manner to promote an understanding that ‘Soul’ is immortal if we look at man as an Association of individual living cells. We need to establish the Identity of that Individual for whose purpose or interest this Association of Individual living cells exists. If we think of Death as a final event, it is not supported by factual evidence. In this Association, death is a daily event. We simply fail to acknowledge this daily event as there is an immortal principle that is escaping this death experience. The Individual thinks that he is alive and sustains his Individuality without getting overwhelmed by the dying process that is continuous. While the human organism is changing its external appearance and identity all the time, the Individuality survives if ‘Soul’ the vital, or operating immortal principle is functioning. The issue or question about ‘transmigration’ of Soul would not arise if every living organism exists strictly as an Individual with an Individuality. As stated before,man has no choice and he must always exist as an Individual even when we use Reproductive Genetic Engineering Technology to produce identical clones with the same genome. The dissolution of matter may not change the Law of Conservation of Energy. If Soul is defined as the God Connection that gives the ability of energy acquisition, the Soul when removed from a physical object to which it has given Individuality, would operate as per the commands of the Controller of Force/Power/Energy. It provides the possibility of carrying the impressions of a previous state of existence into a new state of existence with a new identity and Individuality. During the life span of a given Individual, an association of cells in which death is a daily event, Soul is a continuous principle as its purpose and interest is to maintain Individuality of that Individual.

Soul and The Living Cell:

I attach my ideas to some ideas expressed by others. Sartre is a well-known person. He won the Nobel Prize for literature but declined to accept it. I may not totally agree with his views on consciousness. He shares his view in a manner that people can easily understand. He makes a distinction between objective things and human consciousness. He claims that consciousness is a ‘non-thing’ (‘neant’ or nothingness) and its reality consists in standing back from things and taking a point of view on them. Because consciousness is a non-thing, it does not have any of the causal involvements that things have with other things. If you stand before a mirror, the reflection exists only if it is supported by the presence of a physical being or thing. If the physical thing is taken away, the reflected image is gone but the reflective surface retains its ability to reflect the images of things.

 The Biological Membrane and Consciousness:

In a Living Cell, consciousness reflects its external environment and its internal condition or internal environment. The Living Cell knows, it is aware of its state, fact, and act of its Living. The Living Cell makes contact with its environment by using a cell membrane, a biological membrane, or a bio-membrane. If you carefully look at some of the functions of this membrane, you would discern that the Living Cell has consciousness or awareness of these functions.

The Biological Membrane behaves in a conscious manner and it is not a simple, physical barrier between the Protoplasm, the Living Substance and its environment. If the term ‘soul’ describes a vital principle, or a source of Knowledge, it provides the information with which the living functions like the cellular respiration could be performed. Some molecules and ions can freely move across this Bio-membrane and some are actively pumped in or out of the Cell that involves expenditure of energy. The Living Cell has the ability to recognize the condition of its nucleus, if the DNA is damaged, the Cell can initiate a process and cause its own dissolution.

In a multicellular organism, the consciousness works both at the level of each individual cell and to establish the functioning of the organism as an individual unit. Without functional unity, the organism cannot maintain its biological existence. Cell differentiation is the process by which the individual cells use adaptation to perform specific tasks. The Red Blood Cells perform specific tasks.

The Neurobiological aspects of Consciousness:

In the human Brain Stem, several neurons, and nuclei which are in an area called the Reticular Formation are functionally adapted to compose the contents of human consciousness. The Reticular Formation gives the Capacity for Consciousness. The contents of this consciousness are read in the cortical areas of the cerebral hemispheres and described as Cortical awareness. Most philosophers, most of the psychologists, and several of the religious thinkers pay attention to this Cortical awareness and describe that as human consciousness. We tend to ignore the fact that there would be no Cortical awareness unless there is a Capacity for Consciousness. Most recently, the surgeons removed the complete left cerebral hemisphere from a child to stop convulsive seizures. The child is alive, fully conscious, and hopefully would continue to live in future with some neurological deficits. Just like the human heart which has four different muscular chambers and each has a function of its own; we need to understand consciousness by knowing its components. We need to use separate terms to distinguish these different components. There would be confusion if a term is used without attaching a specific meaning. Cortical awareness is important and is very interesting and yet man can exist and survive with minimal cortical awareness. We have seen children with severe degrees of mental retardation, and they can keep their biological existence if they retain the ability to Compose Consciousness. I want to designate the upper Brain Stem as the Seat of Consciousness and the word consciousness itself must describe the functions of the Brain Stem which are most important for man’s biological existence. A man is clinically dead in the absence of these Brain Stem functions involved in the Capacity of Consciousness. In Clinical Medicine, the term conscious is often used to measure the degree of Arousal or Cortical awareness and hence this subject matter would remain confusing for a long time. If a subject is unconscious, I would not issue a ‘death certificate’. In Clinical Medicine, the term used is ‘Brain Death’ and when Brain Death is diagnosed, the human person for all practical purposes is dead. I would suggest that we must use the term ‘Unconscious’ specifically to indicate the Brain Death which is diagnosed by testing the Brain Stem Reflexes. If the human person is viewed as a single physical thing or object, the integration of functions is achieved at the Brain Stem (Reticular Formation), and he maintains his individuality throughout his physical existence only when this part of the brain is functioning. If you like the term individual soul or Jeeva Atma, its existence is a reflection of this function. To see a reflection, we need two things; the physical object and a reflective surface. The quality of reflecting objects may depend upon the presence of Knowledge. It is not known if this particular kind of knowledge exists as organic molecules; however, it is very well understood that most of the knowledge to perform a variety of biological functions is contained in organic molecules and the most well-known group of these organic molecules are known as DNA. There are Viruses which can function with RNA. Hence, there is still a possibility of finding organic molecules that could be associated with the functional ability called consciousness, awareness, cognition, recognition, responsiveness, perception, memory, intelligence, and association. The most important aspect of ‘association’ is ‘God Connection’ and without this function of ‘association’ man cannot keep his biological existence.

Identity and Individuality:

The issue of spirituality, the nature of Soul and consciousness must be explored in the context of arriving at an understanding of man’s Identity and Individuality. If man is viewed as an association of trillions of cells, we need to know the Identity of that Subject who lives because of the functions of the trillions of cells. The purpose of consciousness at cellular level is to foster functional unity of the multicellular organism and to establish it as an Individual. In a multicellular organism, cells have short lives as individuals. The Subject or the whole organism has a life span of its own and it has effects on individual cells. Multicellularity is accompanied by adaptive subordination of all cells to the requirements of the organism as a whole. To achieve proper numerical balance between functionally related cell groups, the death of many cells is necessary for other cells to reach maturity. This programmed cell death plays an important role in embryological development. Such programmed cell death events are essential if the organism as a whole is to develop its normal final form. Waves of genetically driven cell deaths are critical to the proper modeling of organs and organ systems. We need to know and understand that death of cells is a must to establish the Identity and to sustain the Individuality of the human being. The dying process helps man to understand his Individuality. The Individuality is preserved while death is a daily event at the cellular level. The phenotype or the morphological appearance of the human Subject undergoes constant change during the life journey and yet the Individuality remains unchanged. We recognize the death of this human Subject when his Soul departs from his body. Soul may be stated as an entity which is regarded as being immortal or spiritual part of the person. The Spirit of a dead person generally refers to a principle separate from the body and leading an existence of its own. If Soul is viewed as a Non-thing or Nothingness, it comes into the world of existence by entering the physical being at its conception which becomes conscious or aware of its existence. This consciousness has also existed in a previously existing Living Egg Cell which is the Mother of Life, Energy, and Knowledge. Consciousness by its very nature is immortal, it is eternal, and it has no birth or death. We recognize the arrival and departure of the new product during the Life-Death continuum where the Individuality is unaffected by the changes that are caused by the powerful influence of Time.

Simon Cyrene

Rudolf is reborn to describe the spiritual connection between the Cell and its Energy Provider

I acknowledges my German heritage for I discovered the spiritual connection between man, food, and Providence. Whole Foods, Whole People, and Whole Planet are connected by a material substance called Protoplasm or Cytoplasm, a divine plan to provide nourishment to Life. The photochemical reaction called Photosynthesis works not on the account of the man’s physical or mental work.

The Rudolf Virchow Connection at Whole Foods, Ann Arbor can be best described as the concept of Whole Spirituality, the three dimensional spiritual relationship between the multicellular human organism, food, and the Divine Providence.

Spiritualism – The Cell Theory of Spirituality:

In Biology, cell is the basic or fundamental unit of structure, function, and organization in all living things or it is the building block of life. Let me begin with my respectful tribute to some of the people who contributed to ‘The Cell Theory’, one of the foundations of Biological Sciences. Cells were first observed in the 17th century shortly after the discovery of the microscope. Robert Hooke, british curator of instruments at The Royal Society of London, during 1665 coined the word cell. Dutch microscopist Antonie Van Leeuwenhoek (1632-1723) made over 247 microscopes and examined microorganisms and tissue samples. He gave the first complete descriptions of bacteria, protozoa (which he called animalcules), spermatozoa, and striped muscle. He also studied capillary circulation and observed Red Blood Cells.

Improvements in microscopy during early 19th century permitted closer observation and the significance of cells had received better understanding. Matthias Jakob Schleiden (1838), german botanist, Theodor Schwann (1839), german physiologist, and Rudolf Virchow (1855), german pathologist, and others made important contributions to the Cell Theory that describes cell as the building block of all Life.

The Cell is the smallest unit in the living organism that is capable of carrying on the essential life processes of sustaining metabolism for producing energy and reproducing. Many simple, small, single-celled organisms like Protozoa perform all life functions. In higher, complex, bigger, multicellular organisms, groups of cells are structurally and functionally differentiated into specialized tissues and organ systems. Thus, the Cell Theory includes the following foundational principles of the Biological Sciences:

1. All living things are made up of cells. Cell is the most elementary or basic unit of Life. 

2. Cell is a fundamental unit of structure, function, and organization in all living things including plants and animals.

3. Cells only rise from division of previously existing cells.

4. All cells are similar in composition, form, and function. All cells are basically the same in chemical composition (in spite of variations) in organisms of similar species. For example, all the solid tissues in the human body can be shown to consist largely of similar cells; differing it is true, but that are essentially similar to an Ovum.

5. The cells exhibit functional autonomy. The activity of an organism depends on the total activity of ‘independent’ cells.

6. Energy flow (metabolism and biochemistry) occurs within cells.

7. Cells contain hereditary, biological information (DNA) which is passed from cell to cell during cell division.

The Cell Theory of Spirituality:

The basic or fundamental unit of life in the human organism is derived from the fertilized egg cell that eventually develops into a complete organism. The most significant feature of similarity between the cells of the human body is the presence of a soft, gelatinous, semi-fluid, granular material inside the cell. This substance known as Protoplasm or Cytoplasm, or Cytosol is similar to the ground substance found in the Ovum or the Egg Cell.

This viscous, translucent, colloidal substance is enclosed in a membrane called Cell Membrane, Plasma Membrane or Biological Membrane. A small spherical body called nucleus is embedded in the Protoplasm of the cell. The three essential features of any living cell in the human body are that of the presence of protoplasm, the nucleus, and the cell membrane.

Protoplasm – The Ground Substance of Spiritualism and Spirituality:

I seek the existence of Soul or Spirit in a substance that is basic to life activities, and in a material that is responsible for all living processes. I, therefore, propose that the understanding of the true or real nature of this ground substance of all living matter will help man to discover peace, harmony, and tranquility in all of his internal and external relationships while man exists in a physical environment as a member of a social group, social community, and Society. In this blog post, I would like to pay my respectful tribute to Jan Evangelista Purkinje and Hugo Von Mohl for their great contribution to the scientific understanding of the living substance, living material, and living matter.

Purkinje conducted his research on human vision at the University of Prague and later on, he served there as a Professor of Physiology (1850-69). He went to Germany and was appointed the Chair of Physiology and Pathology (1823-50) at the University of Breslau, Prussia. There Purkinje created the world’s first independent Department of Physiology (1839) and the first Physiological Laboratory (Physiological Institute, 1842). He is best known for his discovery of large nerve cells with many branching extensions found in the cortex of Cerebellum of the brain (Purkinje Cells, 1837). He discovered the fibrous tissue that conducts electrical impulses from the ‘pacemaker’ called Atrioventricular node or A-V node along the inside walls of the ventricles to all parts of the heart to help in Cardiac contractile function (Purkinje Fibers, 1839). In 1835, he invented and introduced the scientific term ‘Protoplasm’ to describe the ground substance found inside young animal embryo cells. He discovered the sweat glands of the skin (1833); he discovered the nine configuration groups of Fingerprints used in biometric identification of man (1823); he described the germinal vesicle or nucleus of the unripe ovum that now bears his name (1825), and he noted the protein digesting power of pancreatic extracts (1836).

Hugo Von Mohl named the granular, colloidal material that made up the main substance of the plant cell as “Protoplasm” in 1846. Purkinje invented the word, but Hugo gave more clarity, understanding, and knowing the nature of this ground substance. He viewed cell as an “elementary organ” and in Physiology he explained Protoplasm as an organ of Motion or Movement, Nutrition, and Reproduction. It is the preliminary material in cellular generation. He was the first to propose that new cells are formed by division of preexisting cells and he had observed this process of Cell Division in the algal cells of Conferva glomerata. His observations are very important to understand the Cell Theory that explains cells as the basic building blocks of Life. He was the first to investigate the phenomenon of the stomatal openings in leaves.

Protoplasm is a complex, viscous, translucent solution of such materials as salts and simple sugars with other molecules, mostly proteins and fats, in a colloidal state, that is dispersed but not dissolved in one another. Carbon, Hydrogen, Oxygen, and Nitrogen constitute more than 90 percent of Protoplasm.

It exhibits properties such as Protoplasmic Streaming or Cytoplasmic Streaming or Motion that is called “Amoeboid Movement.” It has the intrinsic power to change its shape and position. It has the power of Nutrition by which it can attract and obtain the materials necessary for its growth and maintenance from surrounding matter/environment.

The living functions such as Nutrition, Cellular Respiration, and Reproduction performed by Cytoplasm involve acquiring, processing, retaining, and using information to perform tasks in a sequential manner for a predetermined purpose and hence describe Consciousness, Memory, and Intelligence.

The terms Soul and Spirit belong to the materialistic realm where the Physical Reality of man’s biological existence is established. I have not yet discovered any good reason to use the terms Soul and Spirit as a metaphysical or transcendental Reality.

The Inheritance of Cytoplasmic Membrane or Cell or Plasma Membrane:

The Functions of Cytoplasmic Membrane or Cell Membrane or Biological Membrane:

1. Protection: It protects the cell from its surroundings or extracellular environment. Plant cell possess wall over the plasma membrane for extra protection and support. 

2. Holding cell contents: Plasma membranes hold the semi fluid protoplasmic contents of the cell intact; thus keeping the individuality of the cell.

3. Selective Permeability: Cell membrane allows only selected or specific substances to enter into the cell and are impermeable to others. 

• Gases like O₂ and CO₂ can diffuse rapidly in solution through membranes.
• Small compounds like H2O and methane can easily pass through where as sugars, amino acids and charged ions are transported with the help of transport proteins.
• The size of the molecules which can pass through the plasma membrane is 1-15 A⁰. This property is responsible for keeping a cell ‘as a cell’, an individual unit. 

4. Shape: It maintains form and shape of the cell. It serves as site of anchorage or attachment of the cytoskeleton; thus providing shape to the cell (especially in animal cells without cell wall). 

5. Organelles: Cell membrane delimits or covers all sub-cellular structures or organelles like nucleus, mitochondria, plastids, Golgi apparatus, endoplasmic reticulum, microbodies etc. thus protecting them form the surroundings and also helps in maintaining a constant internal environment.

6. Compartmentalization: Cell membrane separate the cells from their external environment and cell organelle from cytosol. It help the cells and their organelles to have their own microenvironments, structural and functional individuality. 

7. Cell Recognition: With the help of glycolipids and glycoproteins on its surface, cell membranes are able to differentiate similar cells from dissimilar ones, foreign substances and cells own materials. Cell recognition is useful for tissue formation and defence against microbes. 

8. Antigens: Cell membranes possess antigens which determine blood grouping, immune response, acceptance or rejection of a transplant (graft rejection by MHC’s on plasma membrane). 

9. Microvilli: They are microscopic finger like projections of plasma membrane present on some cells like intestinal epithelial cells, which are involved in a wide variety of functions, including increasing surface area for absorption, secretion, cellular adhesion etc.

10. Sheaths of cilia and flagella: Cilia and flagella are projections from the cell; made up of microtubules which are covered by an extension of the plasma membrane.

11. Cytoplasmic bridges in plasmodesmata and gap junctions: Plasmodesmata in plant cells and gap junctions in animal cells; meant for intercellular transport and communication, form cytoplasmic bridges between adjacent cells through plasma membrane.

12. Endocytosis and Exocytosis: Bulk intake of materials or endocytosis occurs through development of membrane vesicles or invagination and engulfing by plasma membrane.

Exocytosis: It is reverse of endocytosis that provides for releasing waste products and secretory materials ot of the cells with the help of plasma membrane. 

13. Impulse transmission in neurons: The transmission of a nerve impulse along a neuron from one end to the other occurs as a result of electrical changes across the plasma membrane of the neuron

14. Cell metabolism: Cell membranes control cell metabolism through selective permeability and retentivity of substances in a cell. 

15. Electron transport chain in bacteria: In bacteria; Electron transport chain is located in cell membrane.

16. Osmosis through cell membrane: It is movement of solvent molecules (generally water) from the region of less concentrated solution to the region of high concentrated solution through a semi permeable membrane. Here the semi permeable membrane that helps in osmosis is the cell membrane. Eg: Root cells take up water from the soil by osmosis 

17. Carrier proteins for active transport: They occur in the cell membranes and control active transport of substances. Example, GLUT1 is a named carrier protein found in almost all animal cell membranes that transports glucose across the bilayer or plasma membrane.

18. Plasma Membrane enzymes: Many enzymes are present on the plasma membrane with wide variety of catalytic activity. Example: Red blood cell plasma membranes contain a number of enzymes such as ATPases, anion transport protein, glyceraldehyde 3-phosphate dehydrogenase, protein kinases, adenylate cyclase, acetylcholinesterase.

19. Cell Membrane Receptors: Receptor on the plasma membrane performs signal transduction, converting an extracellular signal into an intra-cellular signal. Membrane possess receptors for hormones, neurotransmitters, antibodies and several other biochemicals.

20. Plasma membrane assisted Cell movements: Undulation and pseudopodia are cell membrane phenomenon involved in cell movement. Amoeba, macrophages and WBCs move with the helps of temporary organelles like pseudopodia. Pseudopods are temporary cytoplasmic projections of the cell membrane in certain unicellular protists such as Amoeba. Some mammalian cells such as fibroblasts can move over a solid surface by wave like undulations of the plasma membrane.

The Ground Substance of Spiritualism and Spirituality. The vital characteristics, the animating principles of Protoplasm could be known by observing Amoeba proteus. The Living Substance works as an organ of Motion or Movement, as an organ of Nutrition, and as an organ of Reproduction to generate new cells which have a life span of their own. In these physiological functions, I describe the characteristics such as Cognition, Consciousness, Memory, and Intelligence as spiritual attributes of Life as they bring functional unity and harmony in the interactions between different parts of the same individual organism while it exists in an environment as a member of a biological community.

The Spirituality of Substance, Function, Organization, Action and Interactions:

To establish the biological existence of the human organism, I add the concept of Spiritualism and Spirituality to the Cell Theory.

The Single Fertilized Egg Cell has ground substance that is of Spiritual nature and the Spiritualism and Spirituality consists of the following functional, and organizational characteristics:

1. The Cell is Conscious of its own existence and knows its internal condition and knows it external environment.

2. The Cell is intelligent and it has the cognitive abilities like perception and memory to acquire information, to retain information, to recall information, and to use information in the performance of its complex tasks in a sequential manner.

3. The Cell has the ability to show characteristics such as mutual cooperation, mutual tolerance, and display functional subordination and subservience while being independent.

4. The Cell grows, divides, and develops into a complete organism while it acquires substances and energy from an external environment. The power of Protoplasm/Cytoplasm to attract matter found in its external environment is called Nutrition. The Cell continuously transforms matter to build matter of its own kind for its own benefit to sustain its  existence with its own identity and individuality. The Organism represents a social group or a biological community of Cells. The Spiritual nature of Protoplasm/Cytoplasm brings this functional harmony and unity in the Social Group or Biotic Community of Cells by bringing together its Essence and Existence.

5. The Cell Theory is incomplete for it does not describe the conditioned nature of the Cell’s existence. The Cell represents a Living System that is thermodynamically unstable. It requires a constant supply of matter and energy from its external environment to sustain its living functions. The concept of Whole Spirituality formulates the connection between the Cell and its external source of matter and energy.

The theoretical claims about Spirit and Soul, the religious and philosophical doctrines of Spiritualism and Spirituality must be verified using the Cell Theory that defines the human organism. To describe Soul or Spirit as  nonmaterial or immaterial Self will not help man to know the real or true man.

Simon Cyrene

Whole Foods, Whole People, and Whole Planet come together in a Wholesome Relationship as God is the Energy Provider, the Original Source of Matter and Energy for Life.