Philosophy of Medicine – Page 2 – Whole Dude

Whole Negligence -Whole Dude at Whole Foods Demands Open Disclosure of Steroid Protocol for Infusion Therapy at Rogel Cancer Center

Michigan Medicine Neglects Taking Care of Common Cold

The most famous instance of Michigan “fumbling the ball” is the 2015 “Trouble with the Snap” play, where a mishandled punt against Michigan State was returned for a game-winning touchdown by the Spartans, 27–23.

Michigan Medicine neglects the Golden Rules of Clinical Medicine to diagnose the challenge that can be posed by a humble medical condition called Upper Respiratory Tract Infection. In their Game Plan, Michigan Medicine jumps into action if and only if the Challenge comes in the shape of a High-Risk Pneumonia. In my analysis, the Steroid Protocol for Infusion Therapy at Rogel Cancer Center is fundamentally flawed for it fails to include a Specific Warning and a Disclaimer to Warn the patient of the Dangers of taking Steroids while experiencing the symptoms of an Upper Respiratory Tract Infection or Common Cold .

What is the Screening Protocol for Cancer Infusion Therapy at Rogel Cancer Center?

Based on standard premedication protocols used at the Michigan Medicine Rogel Cancer Center, particularly for taxane-based chemotherapy, a common steroid regimen involves taking oral dexamethasone the day before and the day of infusion to prevent hypersensitivity reactions and alleviate nausea.

Common Protocol Structure:

Day Before Infusion: Often 8–10 mg of dexamethasone orally.

Day of Infusion: Often 8–10 mg of dexamethasone orally, typically given 1–2 hours before the infusion, often supplemented with intravenous dexamethasone at the clinic.

Day After Infusion: Frequently 4–8 mg of dexamethasone, sometimes twice daily, depending on the specific chemotherapy regimen (e.g., Daratumumab or Paclitaxel protocols).

Important Notes:

Steroid protocols are tailored to the specific treatment (e.g., chemotherapy, immunotherapy, or CAR-T) and the individual patient’s risk of reaction.

Some treatments, such as certain CAR T-cell therapies, require avoiding or limiting corticosteroids before infusion, contrary to standard chemotherapy protocols.

Before chemotherapy is administered, healthcare providers follow a rigorous multi-step screening and assessment protocol to ensure the patient’s body can safely handle the treatment. This process includes baseline medical evaluations, specific lab tests, and safety verifications. Unfortunately, Hi-Tech Michigan Medicine neglects the Clinical Diagnosis of Common Cold until it poses a life-threatening danger called Viral Pneumonia.

Mcdonald’s Screening Protocol to provide Service

***Hi-Tech Michigan Medicine neglects the Clinical Diagnosis of Common Cold until it poses a life-threatening danger called Viral Pneumonia.***

McDonald’s frequently displays “No Shirt, No Shoes, No Service” signs, a common, lawful policy used by businesses to ensure customer safety and maintain service standards. These signs are largely aimed at preventing safety hazards, such as slip-and-fall risks for customers walking in wet from nearby pools or protecting customers from hazards.

Hi-Tech Michigan Medicine neglects the Clinical Diagnosis of Common Cold until it poses a life-threatening danger called Viral Pneumonia.”Historical Michigan TouchDown” without Tossing Ball. World Rejoices Singing ‘Hail to the Victors’.

Michigan Medicine Oncology Department has no Clinical Medicine Protocol to Screen Patients with Upper Respiratory Tract Infections as the Medical Problem does not demand Hi-Tech Medical Interventions.

Reporting Concerns to Michigan Medicine Patient Relations and Clinical Risk Management Program

The Michigan Medicine Office of Patient Relations & Clinical Risk (734-936-4330) manages patient feedback, investigates complaints, and works to improve safety and care quality. They handle concerns when care does not meet expectations, offering a formal process for resolution. The team also manages medical professional liability and investigates safety incidents.

From Patient Relations: Apr 28Apr 28 at 1:20 PM

What specifically led you to believe the screening protocol is “dangerously inadequate” and “medically unethical”?Was there a particular date, visit, or appointment when this occurred?When you say the patient was “deliberately exposed to the consequences of a viral infection,” what do you mean? For example, was the concern about possible exposure to others who were ill, or about proceeding with treatment despite symptoms?Regarding the persistent, recurrent cough, when was this ignored by caregivers?

You are receiving this secure, encrypted email message because it may contain sensitive information. If you have concerns about the validity of this message, contact the sender directly and ensure the email address is a known @med.umich.edu email address.

Sent: Tuesday, April 28, 2026 at 12:16:28 PM EDT

Subject: [SECURE] Patient Relations Concern

I want to bring to your attention that a patient received corticosteroid therapy (Tablet Dexamethasone twice daily on Monday, April 06, Tuesday, April 07, and on Wednesday, April 08, while she was experiencing an Upper Respiratory Tract Infection. This steroid therapy can easily mask symptoms like fever while aggravating the severity of the infection.

Taking dexamethasone tablets during an upper respiratory tract infection (URTI) poses significant risks due to its immunosuppressant nature, which can worsen or mask infections. It may delay viral clearance, promote bacterial superinfections, and increase risks for serious complications like pneumonia or secondary fungal infections.

Key Risks of Dexamethasone with URTIs:

Increased Infection Severity: Dexamethasone lowers your immune system, making it easier to catch infections and harder for your body to fight existing ones. It can cause infections to become more severe or fatal.
Masking Symptoms: By suppressing inflammation, dexamethasone can mask signs of infection, such as fever, causing a delay in necessary medical treatment.
Secondary/Reactivated Infections: It can increase the risk of developing secondary infections or causing latent infections (like tuberculosis or hepatitis B) to become active again.
Increased Viral Load: Evidence suggests that corticosteroids like dexamethasone can delay the clearance of viruses from the body.
Respiratory Complications: The use of dexamethasone in patients with viral infections can be associated with increased mortality and, in some cases, exacerbation of respiratory conditions.
Systemic Side Effects: Even short-term use can lead to side effects such as high blood pressure, hyperglycemia (high blood sugar), and fluid retention. This patient reported to the Clinic with hyperglycemia on the day of Infusion therapy.

1. It is medically unethical to administer drugs without fully disclosing the side effects of the medications. The patient must be duly informed about the risks involved and the patient must get an opportunity to make an informed choice about the therapeutic intervention. The Hospital has billed the patient $400.00 to impart education to learn about the drugs and their adverse effects which could be life threatening. The educator provided by the Hospital has the fundamental duty to assess the risks that of direct concern to the particular, specific patient. The Screening is put in place to avoid negative outcomes for the patient. The Screening Protocol must determine the medical fitness of the patient to receive the therapy planned. Patient’s life is endangered by the administration of Chemotherapy while the patient is infected by an infectious agent and exhibiting clear symptoms of an active infection that produces charateristic symptoms.
2. This unfortunate incident took place on Tuesday, April 7 at the University Hospital and the event is recorded in the patient’s medical documents and the aftercare summary notes available on the patient portal.
3. Patient is placed at the extreme risk of losing life on account of administering a therapeutic agent while immunocompromised. The patient’s age and her medical condition are known risk factors and the presence of an active infection is a known contraindications to the planned infusion therapy on April 07. The treatment plan must not proceed even if the patient with symptomatic Upper Respiratory Tract infection has come to the clinic.
4. On April 07, at the University Hospital, the Physician Assistant deliberately ignored the concerns shared by the patient, her son and her spouse about Dry persistent Cough. The educator gave false assurances by dismissing the concern and suggested that viral infections in the community cause these problems like cough and failed to mention the risk of Pneumonia that can cause respiratory failure and death.

The patient talked to Patient Relations on the phone on April 28. 2026 to confirm that she has concerns to share about her Office Visit with PA-C on Tuesday, April 07, 2026, 2.40 P.M., at Thoracic Oncology Clinic, University of Michigan Health Infusion Area, Rogel Cancer Center for assessment of her medical fitness prior to Infusion Therapy prescribed by Michigan Medicine Oncologist. The Medical Negligence of this caregiver directly resulted in patient’s admission to University Hospital on April 12, 2026 and she remains in the Hospital on this day, Wednesday, April 29, 2026 suffering from the direct consequences of infection with Human Metapneumovirus (hMPV) and lost the benefit of receiving the planned palliative care scheduled for April 28, 2026. The evidence of this infection was apparent on Tuesday, April 07, 2026 during the above mentioned Office Visit.

Medical negligence is a legal concept defining when a healthcare professional deviates from the accepted standard of care, causing injury or death to a patient. It occurs when a provider acts—or fails to act—in a way a reasonably competent professional would not, often labeled as medical malpractice. Key elements include duty, breach, causation, and damages.

Failure to Obtain Informed Consent: Failing to inform a patient of the risks of a procedure, leading to an injury they would have otherwise avoided.
World Class Medical Care refers to Stringent Quality Standards: Adherence to superior clinical guidelines that often result in significantly lower readmission rates compared to national averages.
Screening Protocol for giving Cancer Chemotherapy to Patients: Before chemotherapy is administered, healthcare providers follow a rigorous multi-step screening and assessment protocol to ensure the patient’s body can safely handle the treatment. This process includes baseline medical evaluations, specific lab tests, and safety verifications.

***Unfortunately, Hi-Tech Michigan Medicine neglects the Clinical Diagnosis of Common Cold until it poses a life-threatening danger called Viral Pneumonia.***

High-tech Medicine falls short for neglecting clinical medicine

High-tech medicine often falls short of its promise because an overemphasis on technological solutions frequently leads to the neglect of essential clinical skills and humanistic care. While advanced diagnostic tools and AI have enhanced medical capabilities, they have also contributed to a “high-tech, low-touch” environment that can dehumanize patient care, reduce, and increase.

Impact of Neglecting Clinical Medicine

Erosion of the Patient-Physician Relationship: Technology has become an obstacle to direct patient-physician interaction. The art of listening and physical examination is being lost as clinicians focus more on screen-based data and automated tools.

Dehumanization of Care: Patients are increasingly treated as a collection of data points rather than whole individuals. The subjective, personal experience of illness is often ignored in favor of biochemical or imaging results.

Data Overload vs. Meaningful Care: Modern, and are often, leading to “drowning in data but starving for meaning”.

Increased Medical Errors: Over-reliance on technology (e.g., or) can lead to new types of errors. Poorly designed Electronic Health Records (EHRs) lead to “check-the-box” workflows that obscure the patient’s true narrative.

The “High-Tech” Paradox

“Prisoner’s Dilemma”: Hospitals often invest in expensive technology (e.g.,) to attract talent, not necessarily because it improves patient outcomes.

False Efficiency: The time spent on and digital documentation contributes to clinician burnout and reduces the time available for direct patient care.

Misleading Solutions: AI and High-Tech gadgets cannot replace the compassionate, “high-touch” care required to treat anxious and uncertain patients.

The Need for Balance
To avoid falling short, healthcare must reintegrate the “art” of medicine—empathy, communication, and physical touch—with technological advancements. Experts suggest that technology should be a supportive tool, not a substitute for the patient-physician connection.

Prioritize Human Interaction: Reimbursement models should value time spent listening to patients over simply conducting tests and procedures.

Improve Technology Design: Future development must focus on usability and reducing, rather than adding to, the burden on clinicians.

Acknowledge Limits: Michigan Medicine must recognize that it is not ready to replace human judgment with high-cost technology to address the health care challenges posed by the most common illnesses that impact the Community.

Spirituality Science – Whole Medicine: Hippocrates, Greek physician of antiquity is traditionally regarded as the Father of Medicine. He belonged to the Greek Island of Kos. Michigan Medicine must recognize that it is not ready to replace human judgment with high-cost technology to address the health care challenges posed by the most common illnesses that impact the Community.

Michigan Medicine Fumbling the Ball, What is it’s Game Plan?

Michigan Medicine Neglects Taking Care of Common Cold

On October 17, 2015, No. 7 Michigan State defeated No. 12 Michigan 27–23 in Ann Arbor following a disastrous, mishandled punt by Michigan with 10 seconds left. Spartans player Jalen Watts-Jackson recovered the fumble and ran 38 yards for a touchdown as time expired, creating one of the most iconic, shocking endings in college football history. Similarly, Michigan Medicine neglects the Golden Rules of Clinical Medicine to diagnose the challenge that can be posed by a humble medical condition called Upper Respiratory Tract Infection. In their Game Plan, Michigan Medicine jumps into action if and only if the Challenge comes in the shape of a High-Risk Pneumonia.

What is the Screening Protocol for Cancer Infusion Therapy at Rogel Cancer Center?

Mcdonald’s Screening Protocol to provide Service

Michigan Medicine Oncology Department has no Clinical Medicine Protocol to Screen Patients with Upper Respiratory Tract Infections as the Medical Problem does not demand Hi-Tech Medical Interventions.

Reporting Concerns to Michigan Medicine Patient Relations and Clinical Risk Management Program

From Patient Relations: Apr 28Apr 28 at 1:20 PM

Sent: Tuesday, April 28, 2026 at 12:16:28 PM EDT

Subject: [SECURE] Patient Relations Concern

Key Risks of Dexamethasone with URTIs:

Increased Infection Severity: Dexamethasone lowers your immune system, making it easier to catch infections and harder for your body to fight existing ones. It can cause infections to become more severe or fatal.
Masking Symptoms: By suppressing inflammation, dexamethasone can mask signs of infection, such as fever, causing a delay in necessary medical treatment.
Secondary/Reactivated Infections: It can increase the risk of developing secondary infections or causing latent infections (like tuberculosis or hepatitis B) to become active again.
Increased Viral Load: Evidence suggests that corticosteroids like dexamethasone can delay the clearance of viruses from the body.
Respiratory Complications: The use of dexamethasone in patients with viral infections can be associated with increased mortality and, in some cases, exacerbation of respiratory conditions.
Systemic Side Effects: Even short-term use can lead to side effects such as high blood pressure, hyperglycemia (high blood sugar), and fluid retention. This patient reported to the Clinic with hyperglycemia on the day of Infusion therapy.

Failure to Obtain Informed Consent: Failing to inform a patient of the risks of a procedure, leading to an injury they would have otherwise avoided.
World Class Medical Care refers to Stringent Quality Standards: Adherence to superior clinical guidelines that often result in significantly lower readmission rates compared to national averages.
Screening Protocol for giving Cancer Chemotherapy to Patients: Before chemotherapy is administered, healthcare providers follow a rigorous multi-step screening and assessment protocol to ensure the patient’s body can safely handle the treatment. This process includes baseline medical evaluations, specific lab tests, and safety verifications.

High-tech Medicine falls short for neglecting clinical medicine

Impact of Neglecting Clinical Medicine

Data Overload vs. Meaningful Care: Modern, and are often, leading to “drowning in data but starving for meaning”.

The “High-Tech” Paradox

“Prisoner’s Dilemma”: Hospitals often invest in expensive technology (e.g.,) to attract talent, not necessarily because it improves patient outcomes.

False Efficiency: The time spent on and digital documentation contributes to clinician burnout and reduces the time available for direct patient care.

Misleading Solutions: AI and High-Tech gadgets cannot replace the compassionate, “high-touch” care required to treat anxious and uncertain patients.

Prioritize Human Interaction: Reimbursement models should value time spent listening to patients over simply conducting tests and procedures.

Improve Technology Design: Future development must focus on usability and reducing, rather than adding to, the burden on clinicians.

Whole Existence – Whole Inheritance – Whole Dude at Whole Foods Wishes You a Happy Mother’s Day

The Celebration of Maternal Cytoplasmic Inheritance

Excerpt: This piece pays tribute to Mother’s Day 2026, focusing on the significance of maternal cytoplasmic inheritance in human creation and existence. The author extols the divine principles of fatherhood and motherhood, which shape life through a three-fold inheritance: the human genome, cytoplasmic inheritance, and the inheritance of the physical and social environment. The author emphasizes the role of the mother cell in bequeathing life, energy, and knowledge, via the mitochondria – the cellular powerhouse. The mother cell also carries unique attributes that, in combination with paternal genes, ensure every human being displays their distinct individuality. The cell’s functionality in acquiring and distributing energy, and its cytoplasmic intelligence, are ascribed to maternal cytoplasmic inheritance.

To celebrate Mother’s Day on Sunday, May 10, 2026, I account for my human existence using the phrase Whole Inheritance which includes the contributions of the Divine Principle, the Father Principle, and the Mother Principle. The term inheritance must include the inheritance of Matter and Knowledge from Mother apart from the genome as the fact of existence needs the support from an external environment at any given time and place.

The Divine Principle ensures the creation of the newborn who arrives in a physical and social environment to exist as an Individual with Individuality, an original, one of its own kind of object without any exceptions.

The Celebration of Maternal Cytoplasmic Inheritance

The establishment of human existence primarily involves three kinds of inheritance. 1. The Inheritance of the Human Genome, 2. The Cytoplasmic Inheritance which includes the inheritance of cytoplasm and its organelles, the Cell Membrane or Biological Membrane, and 3. The Inheritance of Physical and Social Environment that supports the existence

**Happy Mother’s Day, Sunday, May 10, 2026. The celebration of maternal cytoplasmic Inheritance. The Divine attribute of Motherhood is the Maternal Cytoplasmic Inheritance.**

The Inheritance of Cell or Biological Membrane:

Living cells have a corporeal substance called Protoplasm that has the ability of Spiritual Biotic Interactions. The Biological Membrane or Cell Membrane separates the cell from its environment and other living cells present in the environment. Cells use unique proteins, biological molecules and receptor sites to recognize the other living cells and use chemical signals to facilitate the interactions. Such interactions between living cells have the characteristics of consciousness or awareness.

The Functions of Biological Membrane:

1. Protection: It protects the cell from its surroundings or extracellular environment. Plant cell possess wall over the plasma membrane for extra protection and support.

2. Holding cell contents: Plasma membranes hold the semi fluid protoplasmic contents of the cell intact; thus keeping the individuality of the cell.

3. Selective Permeability: Cell membrane allows only selected or specific substances to enter into the cell and are impermeable to others.

Gases like O₂ and CO₂ can diffuse rapidly in solution through membranes.
Small compounds like H2O and methane can easily pass through where as sugars, amino acids and charged ions are transported with the help of transport proteins.
The size of the molecules which can pass through the plasma membrane is 1-15 A⁰. This property is responsible for keeping a cell ‘as a cell’, an individual unit.

4. Shape: It maintains form and shape of the cell. It serves as site of anchorage or attachment of the cytoskeleton; thus providing shape to the cell (especially in animal cells without cell wall).

5. Organelles: Cell membrane delimits or covers all sub-cellular structures or organelles like nucleus, mitochondria, plastids, Golgi apparatus, endoplasmic reticulum, microbodies etc. thus protecting them form the surroundings and also helps in maintaining a constant internal environment.

6. Compartmentalization: Cell membrane separate the cells from their external environment and cell organelle from cytosol. It help the cells and their organelles to have their own microenvironments, structural and functional individuality.

7. Cell Recognition: With the help of glycolipids and glycoproteins on its surface, cell membranes are able to differentiate similar cells from dissimilar ones, foreign substances and cells own materials. Cell recognition is useful for tissue formation and defence against microbes.

8. Antigens: Cell membranes possess antigens which determine blood grouping, immune response, acceptance or rejection of a transplant (graft rejection by MHC’s on plasma membrane).

9. Microvilli: They are microscopic finger like projections of plasma membrane present on some cells like intestinal epithelial cells, which are involved in a wide variety of functions, including increasing surface area for absorption, secretion, cellular adhesion etc.

10. Sheaths of cilia and flagella: Cilia and flagella are projections from the cell; made up of microtubules which are covered by an extension of the plasma membrane.

11. Cytoplasmic bridges in plasmodesmata and gap junctions: Plasmodesmata in plant cells and gap junctions in animal cells; meant for intercellular transport and communication, form cytoplasmic bridges between adjacent cells through plasma membrane.

12. Endocytosis and Exocytosis: Bulk intake of materials or endocytosis occurs through development of membrane vesicles or invagination and engulfing by plasma membrane.

Exocytosis: It is reverse of endocytosis that provides for releasing waste products and secretory materials ot of the cells with the help of plasma membrane.

13. Impulse transmission in neurons: The transmission of a nerve impulse along a neuron from one end to the other occurs as a result of electrical changes across the plasma membrane of the neuron

14. Cell metabolism: Cell membranes control cell metabolism through selective permeability and retentivity of substances in a cell.

15. Electron transport chain in bacteria: In bacteria; Electron transport chain is located in cell membrane.

16. Osmosis through cell membrane: It is movement of solvent molecules (generally water) from the region of less concentrated solution to the region of high concentrated solution through a semi permeable membrane. Here the semi permeable membrane that helps in osmosis is the cell membrane. Eg: Root cells take up water from the soil by osmosis

17. Carrier proteins for active transport: They occur in the cell membranes and control active transport of substances. Example, GLUT1 is a named carrier protein found in almost all animal cell membranes that transports glucose across the bilayer or plasma membrane.

18. Plasma Membrane enzymes: Many enzymes are present on the plasma membrane with wide variety of catalytic activity. Example: Red blood cell plasma membranes contain a number of enzymes such as ATPases, anion transport protein, glyceraldehyde 3-phosphate dehydrogenase, protein kinases, adenylate cyclase, acetylcholinesterase.

19. Cell Membrane Receptors: Receptor on the plasma membrane performs signal transduction, converting an extracellular signal into an intra-cellular signal. Membrane possess receptors for hormones, neurotransmitters, antibodies and several other biochemicals.

20. Plasma membrane assisted Cell movements: Undulation and pseudopodia are cell membrane phenomenon involved in cell movement. Amoeba, macrophages and WBCs move with the helps of temporary organelles like pseudopodia. Pseudopods are temporary cytoplasmic projections of the cell membrane in certain unicellular protists such as Amoeba. Some mammalian cells such as fibroblasts can move over a solid surface by wave like undulations of the plasma membrane.

The Divine Principle has to be both male and female and in this article, I present the feminine aspect of Divine Principle as “Whole Angel”, the harmonious blending or coming together of Angel of Beauty, Angel of Mercy, and Angel of Knowledge. My understanding of Mother and Motherhood comes from the study of the building blocks of Life. The most important building block of human life is the fertilized Egg Cell.

Happy Mother’s Day, Sunday, May 10, 2026. The celebration of maternal cytoplasmic Inheritance. The newborn baby upon separation from its mother begins life as an independent living entity by initiation of its vital, living functions such as Respiration and Circulation. To survive in physical world, the baby needs the ability to breathe on its own and circulate the vital supply of Oxygen to all tissues and organs of the entire body.

THE DIVINE MOTHER OF LIFE, ENERGY, AND KNOWLEDGE : I DESCRIBE THE CONCEPT OF "WHOLE ANGEL" AS THE HARMONIOUS BLENDING OR COMING TOGETHER OF ANGEL OF BEAUTY, ANGEL OF MERCY, AND ANGEL OF KNOWLEDGE . — HAPPY MOTHER’S DAY, Sunday, May 10, 2026. The celebration of maternal cytoplasmic inheritance. THE DIVINE ATTRIBUTE OF MOTHERHOOD IS THE MATERNAL CYTOPLASMIC INHERITANCE. I DESCRIBE THE CONCEPT OF “WHOLE ANGEL” AS THE HARMONIOUS BLENDING OR COMING TOGETHER OF ANGEL OF BEAUTY, ANGEL OF MERCY, AND ANGEL OF KNOWLEDGE .

The Father and the Mother – The Principles governing Life:

Father is described as the male parent, an ancestor, an originator, and as a Controller. Very often, in the Land of India, God is considered as both the Father and the Mother of all life forms. Mother is described as the female parent and something that is regarded as a ‘Source’. In the Indian tradition, Father may be viewed as the ‘Prime Cause’ and Mother is the Source of ‘Prime Energy’. Mother is the source of energy in performance of all kinds of actions and in accomplishment of all kinds of work. The Mother Principle represents the Endeavor/Work/Effort that makes action possible. If Life is defined as function at the level of biological molecules, Mother represents the Source or the Origin of these organic molecules; Mother is the Source of Energy for the synthesis of these organic molecules; and Mother is the Source of Knowledge that provides the ability of recognition and the ability to use the molecules in a sequential manner to manage the biochemical reactions of these organic molecules to function as Life.

Angel of Beauty – Mother – Source of Life:

The complex, multicellular human organism begins as a single cell. That single cell is the source of life, energy, and knowledge.

I, as a human organism exist in this world as I arrived from a previously existing ‘Mother Cell’. By repeated cell growth and cell division or replication known as ‘Mitosis’, the human organism grows and develops into a form containing thousands of billions of cells. This process of development is called ‘Morphogenesis’ which involves not only cell growth but differentiation into specialized types of cells. All the tissues and organs of which the human body is composed have originally developed from a microscopic cell known as ‘Ovum’ or the ‘Egg Cell‘.

This Ovum or Egg Cell may be regarded as a perfect cell and could be described as ‘Mother Cell’. All the solid tissues in the human body can be shown to consist largely of similar cells; it is true that they may differ, but they are essentially similar to an Ovum. The Ovum is a reproductive cell that is adapted to meet the nutritional requirements of the early developmental stages of the embryo. It is always a large cell because it contains sufficient cytoplasmic substance for the development of a self-sufficient embryo. Some of the substance which is packaged in yolk particles contains cell components; typically an Ovum contains sufficient quantities of components for many cells. Thus the Ovum need not grow as it divides; as the nuclei divide, the cytoplasm subdivides until the Ovum consists of a large number of normal-sized cells. By contrast, the male reproductive cells known as ‘Spermatozoa’ contain very little cytoplasm and they cannot further divide into new cells.

THE Source OF Life – Protoplasm:

The most significant feature of the similarity between the cells of a man and that of the ‘Mother Cell’ from which he had arrived is presence of a soft gelatinous, semi-fluid, granular material inside the cell. This substance known as ‘Protoplasm’ is similar to that found in the Ovum. The Ovum consists of this viscous, translucent, colloidal substance enclosed in a membrane called Plasma Membrane. A small spherical body called nucleus is embedded in the protoplasm. The protoplasm could also be differentiated into cytoplasm and nucleoplasm based upon its location. Cytoplasm refers to protoplasm located outside the nucleus. Nucleoplasm refers to protoplasm located inside the nucleus. The two essential features of any living cell in the human body are that of presence of protoplasm and the nucleus.

The most striking characteristics of protoplasm are its vital properties of “Motion” and “Nutrition”. Protoplasm has the intrinsic power to change its shape and position. Motion of protoplasm is called ‘amoeboid movement’ as it resembles the movements observed in the Amoeba proteus animalcule. Nutrition is the power which protoplasm has of attracting itself the materials necessary for its growth and maintenance from surrounding matter and environment. The Egg Cell or the Ovum is the Source or the Mother of Life. This living matter, living substance, or corporeal material has divine attributes. It is conscious, it is aware, and it performs cognitive functions to sustain its own living condition.

Heredity is the sum of all biological processes by which particular characteristics are transmitted from parents to their offspring. A child inherits a genetic constitution from its biological parents. This hereditary endowment, the total of the genes that the child has received from both parents is called the genotype. The genotype of an individual is formed from the constituents of the genotypes of his parents. The genotype in a fertilized Egg Cell influences the developmental pattern of the child. Progeny is not exact duplicates of their parents and usually vary in many traits. Heredity and Variation are two sides of the same coin. The outward appearance of an organism is called the phenotype. The same individual shows different phenotypes in childhood, in adulthood, and in old age. The genotype, on the other hand, does not change during an individual’s life. Each cell in the human body contains the same total genetic information that was present in the fertilized Egg. However, the cells are not identical. In different types of cells, groups of genes are controlled (in effect switched on and off) by various biochemical processes, so that each cell manufactures the proteins and structures needed for it to function. Cells are regulated by the DNA in the nucleus and by the transfer of selected portions of the DNA information to the cytoplasm through the intermediate molecules of ‘Messenger RNA’. It is estimated that, on average, only about 10 percent of the genes of any cell are functional; selection of functional genes varies with the type of cell. This biological phenomenon of selective gene functioning may contribute to what I term as ‘The Law of Individuality’. Deoxyribonucleic acid or DNA accounts for the ability of all living matter to replicate itself exactly and to transmit genetic information from parent to offspring. The child maintains its individuality by selectively switching the inherited DNA on and off. The Law of Individuality applies to all living organisms. Despite the basic biological, chemical, and physical similarities found in all living things, diversity of life exists not only among and between species but also within every natural population.

The Mother Cell is the Source of Life for its child and yet the child comes into existence as a brand new and original product with its own Identity and Individuality. The Mother Cell does not manufacture the new multicellular organism called child. A child is always a created object even when it derives its life from a Mother Cell.

Angel of Mercy, Grace, and Compassion – Mother – Source of Energy:

**Happy Mother’s Day, Sunday, May 10, 2026. The celebration of maternal cytoplasmic inheritance. The Divine Source of Energy.**

To maintain life an organism not only repairs or replaces (or both) its structures by a constant supply of the materials of which it is composed but also keeps its life processes in operation by a steady supply of energy.

Living systems must be supplied energy for continual synthesis of new organic molecules and to replace or to repair broken organic molecules. This functional activity; the processes of synthesis and breakdown of organic molecules by a living cell, is known as metabolism. Metabolism involves a living system’s continual exchange of some of its materials with its surroundings, principally in the process of building up or destroying its protoplasm. growth involves a higher rate of synthesis of protoplasm than a rate of breakdown of that matter.

Organisms acquire energy for their metabolism by two general methods and could be classified as autotrophs or self feeders and heterotrophs or feeders of other organisms. Plants are known as Photoautotrophs as they acquire useful free energy from the energy of Sunlight. In a process known as Photosynthesis, plants use Sunlight to break water into Oxygen and Hydrogen. Hydrogen is then combined with Carbon dioxide to produce such energy-rich molecules as Adenosine triphosphate (ATP) and carbohydrates and the Oxygen is released back into the atmosphere. Humans and most other animals are known as heterotrophs – these organisms acquire energy by the controlled breakdown of pre-existing organic molecules (food) supplied by other organisms. Humans utilize the atmospheric Oxygen (released by plant life) to combine chemically with organic matter (food) they have eaten and release Carbon dioxide and water as waste products. Metabolic processes do not occur in one step. It is not similar to burning sugar in air.

The glucose, a simple sugar is broken down by a series of successive and coordinated steps, each mediated by a particular and specific enzyme. The human organism extracts useful energy by a metabolic process described as Oxidation-Reduction Reactions. The glucose is broken down in a series of about 71 enzymatically catalyzed steps. The first 11 of these biochemical reactions do not involve the use of Oxygen. These Oxidation-Reduction Reactions occur in intracellular organelles known as Mitochondria in the cytoplasm of cells.

Mitochondria – The Powerhouse of Cells:

Mitochondria are typically sausage-shaped particles about 0.5 to one micron wide and about 5 to 10 microns long. They are surrounded by an outer unit membrane which controls the passage of material into and out of the mitochondria and govern their internal environment. The inner membrane is the site of the respiratory functions that make the mitochondria the so-called Powerhouse of the Cell. The inner membrane is folded repeatedly into shelf like folds called cristae which contain the enzymes that play an essential role in conversion of the energy of foodstuffs into the energy used for cellular activities.

Mitochondria and Chloroplasts – A Divine Source for Energy Acquisition:

Mitochondria and Chloroplasts found in the green plant cells perform the same fundamental processes. The Chloroplasts contain the green colored pigment known as Chlorophyll. The Chloroplasts convert the energy of Sunlight into energy-rich ATP and use ATP to convert Carbon into specific organic substances. The most important equations for living things are mutually inverse. Respiration of human organisms represents the reverse of Photosynthesis of Green Plants. Both Mitochondria and the Chloroplasts are semi-independent and self-reproducing parts of the living cells. They have a degree of autonomy and they are unlike the other components of cells. Mitochondria contain DNA in the form of a Chromosome arranged in a ring. The DNA of Mitochondria has different distribution of bases from that of the DNA found in the Chromosomes present in the nucleus. Mitochondria carry the genes for their own replication and for the enzymes found in them. They can synthesize some of their own proteins and reproduce by themselves. In one respect the mitochondria function as the parts of the cells and in another respect, they behave like independent organisms that reproduce on their own.

The Mother Cell is the source of Mitochondria found in all the cells of my human body. During the Growth and Development of Human Embryo and Fetus, all the newly formed cells contain Mitochondria derived from the Egg Cell. Hence, mother as a biological parent represents the Source of Energy for all the Living Functions and activities of her children. I cannot move a muscle in my body without drawing energy supplied by the maternal Mitochondria which continue to live and replicate establishing my mother as the Source of Energy for my existence during my entire Life’s Journey.

Angel of Knowledge – Mother – Source of Knowledge:

Life is the state of an individual characterized by the capacity to perform certain functional activities including the ability of responsiveness. Life is further characterized by presence of complex transformation of organic molecules and by organization of such molecules into the successively larger units of protoplasm, cells, organs, and tissues. Hence, I have defined Life as “Knowledge in Action.”

Responsiveness represents the ability of an organism to change in response to alteration in its environment. Responsiveness, alertness, awareness, and consciousness separates living from nonliving matter and defines life’s underlying principle. Living cells are aware or conscious of the environment in which they exist as well as the state of their own internal environment. The one very important part of environment of a cell is other cells. The ability called awareness and responsiveness is important for recognition, association, and cooperation between cells. Cells function together by exchanging chemical signals.

THE Cytoplasmic or Maternal Inheritance:

**Happy Mother’s Day, Sunday, May 10, 2026. The celebration of maternal cytoplasmic Inheritance. Mitochondria are inherited from maternal cytoplasm.**

Deoxyribonucleic acid or DNA accounts for the ability of all living matter to replicate itself exactly and to transmit genetic information from parent to offspring. While offspring inherit a genetic constitution and hereditary traits from both parents, some characteristics are inherited through the maternal line only. For example, there are no Chlorophyll containing Chloroplasts in pollen grains of (male) flowers. The act of Pollination does not contribute this most important characteristic known as Chloroplasts. Chloroplasts are found only in the Egg Cells of (female) flowers. Similarly, humans inherit the Powerhouses called Mitochondria only from Maternal cytoplasm.

A Cytoplasmic Inheritance is entirely Maternal. Human functions that involve Sensory Perception, Mental Cognition, Learning, and the functions of Memory and Consciousness should be viewed as functions of the cytoplasm. Cytoplasm represents the Seat of Knowledge. Man begins Life as a single cell with its cytoplasm. The cell grows and divides while building more of its cytoplasm. Knowledge is the Fact of Knowing, the State of Knowing, and the Act of Knowing a range of information. The Mother or the Source of Knowledge is the Maternal Cytoplasm inherited from the Egg Cell, Ovum, or the Mother Cell.

Whole Identity-Whole Dude investigates his Identity at Michigan Medicine Hospital

Whole Dude at Whole Foods was visiting the Michigan Medicine Hospital, Medical Ward, Room 7104 on Sunday, April 19, 2026. Asking direct questions, a physician visiting the room displayed inability to think microscopically to know Whole Dude as a Whole Person. Her questions about the occupation and education of Whole Dude are not relevant to verified Science which describes Human Identity. All said and done, the physician could not account for the findings of the CT Chest scans and Chest X-rays.

The purpose of the physician’s visit is that of interpreting the information provided by the CT Chest scans and the Chest X-rays of the patient who received Chemo and Immunotherapy to treat Lung carcinoma and receiving care for Lung inflammation. Is it Pneumonia caused by Human Metapneumo virus, unknown infectious agent or autoimmune response triggered by the prior medical intervention? When I look at the person microscopically, I recognize, normal, healthy Lung cells, cancerous Lung cells, infectious viral/bacterial agents, the cells and molecules of antibodies of the Immune system. I have to know the nature of interactions between these players. Man is constituted as a Multicellular Organism and none of those Building Blocks of the Human Body when examined under a microscope will reveal the identity of the Man in terms of his Education or Occupational Status unless the Occupation is the cause of a specific Occupational Disease.

Cell surface markers are specialized proteins and carbohydrates attached to the plasma membrane that identify, classify, and determine the function of specific cell types. Key markers include Clusters of Differentiation (CD) molecules (e.g., CD4, CD8), MHC molecules, and adhesion receptors. These markers are crucial in immunology, stem cell research, and cancer diagnosis, enabling the identification and sorting of cells via Flow Cytometry Analysis – AnyGenes.

Key Types of Cell Surface Markers

CD Antigens (Clusters of Differentiation): The most common nomenclature used to identify leukocytes (white blood cells) and other cells, with over 370 types identified in humans. Examples include CD3 (T cells), CD19/CD20 (B cells), and CD14/CD163 (macrophages).
MHC Molecules (Major Histocompatibility Complex): Unique glycoproteins that act as self-recognition sites for the immune system, distinguishing self from foreign cells.
Adhesion Molecules: Proteins such as PECAM1, VCAM1, and ICAM2 that mediate cell-cell or cell-matrix interactions.
Stem Cell Markers: Specific surface proteins like CD140b, CD56, and CD184 used to identify and isolate stem cells from tissues such as bone marrow.
Cancer-Associated Markers: Molecules overexpressed in tumors, such as EPCAM or tumor-specific antigens, used to monitor disease or target therapy.

Functions of Surface Markers

Cell Identification & Sorting: Allowing researchers and clinicians to classify cells into specific lineages or developmental stages.
Signal Transduction: Acting as receptors or ligands that receive extracellular signals and initiate intracellular signaling pathways.
Immune Recognition & Response: Participating in immune activation (e.g., CD4, CD8) or facilitating cell adhesion.
Diagnosis and Therapy: Serving as targets for monoclonal antibodies, particularly in diagnosing hematological malignancies and personalized medicine.

Michigan Medicine AHEAD Study uses unscientific demographic information to ascertain the Identity of Whole Dude for participation in Medical Research Project

Whole Foods-Whole Inspiration-Whole Language

Michigan Medicine should have known better and must use valid, verified principles to identify every Human Being as a Specific Individual with Individuality without depending upon unverified claims about Race and Ethnicity.

**Michigan Medicine AHEAD Study has no Research Protocol to verify the Identity and Individuality of the Complex, Multicellular, Human Organism**

Man describes his identity in terms of his personal name, age, gender, race, ethnicity, place of origin, language, religion, political, occupational, or social affiliation. In reality, the man is an association of trillions of individual cells. Michigan Medicine should have known better and must use valid, verified principles to identify every Human Being as a Specific Individual with Individuality without depending upon unverified claims about Race and Ethnicity.

The AHEAD Study is researching the safety and effectiveness of an investigational medication in people who might be at increased risk for developing memory loss associated with Alzheimer’s Disease. The study is looking for participants age 55-80 years old, who have generally normal memory function in daily life, and who are not being treated for memory problems. For individuals age 55-64 years old, an additional risk factor is required, such as a parent or sibling with Alzheimer’s Disease or previous biomarker testing showing increased risk for developing Alzheimer’s Disease. This study sees participants in Ann Arbor. Contact Lauren Mackenzie at spearsl@med.umich.edu or 734-232-2415, Clinical Research Coordinator, Neurology Clinical Trials Organization (NeCTO), NCAC.

On Tuesday, December 05, 2023, at the Michigan Clinical Research Unit (MCRU) at the Cardiovascular Center (CVC), Whole Dude was interviewed for participating in the AHEAD Study. Whole Dude was asked to provide their demographic information to register their personal identity for participation in the Medical Research Project. Further, Whole Dude was asked to provide information about their Race which is entirely determined by the Place of their Birth, and the Country of their Birth. Whole Dude was asked to verify their Ethnicity using the one and only Criteria which relates to the Ethnicity of Hispanic people.

Whole Dude remains totally dismayed to learn that the Research Project has not established its own Protocol to describe the Identity and Individuality of the Specific Human Individual who may be included as a Research Subject in Clinical Medical Research. Michigan Medicine should have known better and must use valid, verified principles to identify every Human Being as a Specific Individual with Individuality without depending upon unverified claims about Race and Ethnicity.

Man is constituted as a Biotic Community of socially interacting cells and microbes

**Whole Dude at Whole Foods examines the complex issues of identity and individuality in the multicellular human organism**

Whole Dude at Whole Foods examines the complex issues of identity and individuality in the multicellular human organism. The Law of Individuality leaves the Individual with no choice other than that of expressing variability while being a member of a Social Group which may have a fixed Identity.

The Cellular and the Molecular Basis of Identity and Individuality

Whole Dude at Whole Foods has Cellular and Molecular Basis for his Identity and Individuality. Human Identity undergoes changes due to the aging process but the Human Individuality persists unchanged. Individuality and the Genome. The Law of Individuality governs all Individual Living Things.

In 1965, while Whole Dude was a student of Human Anatomy at Kurnool Medical College, they had the opportunity to know Dr. J. C. B. Grant (1886-1973), the author of Grant’s Atlas of Anatomy. The 5th Edition of his Atlas was published in 1962 and was available in India in their Medical College Library.

John Charles Boileau Grant (1886–1973)

Dr. J C B Grant. Whole Dude coined the phrase Whole Individualism to discover Man by a study of the building blocks, the structural units and organization of the human body. To defend human existence, Whole Individualism lays the emphasis on knowing the person who is at risk apart from knowing the agent posing the risk.

Born in Loanhead (south of Edinburgh) in 1886, Grant studied medicine at the University of Edinburgh Medical School and graduated with an M.B., Ch.B. degree in 1908. While at Edinburgh, he worked under the renowned anatomist Daniel John Cunningham. Grant became a decorated serviceman of the Royal Army Medical Corps during the First World War before moving to Canada.

badge, headdress, British, Royal Army Medical Corps (INS 8067) Brass cap badge of the rod of Aesculapius with a serpent entwined round it, head uppermost and looking left, all within a laurel wreath. Above, an Imperial (King’s) crown and below, a scroll bearing ROYAL ARMY MEDICAL CORPS. Slider to reverse. Copyright: � IWM. Original Source: http://www.iwm.org.uk/collections/item/object/30078877

He established himself as an ‘anatomist extraordinary’ at the University of Toronto, publishing three textbooks that form the basis of Grant’s Anatomy. The textbooks are still used in anatomy classes today, and made unforgettable memories for those who found themselves in his classes nearly a century ago. One of Grant’s many accomplishments was establishing a division of histology within the department.

As a medical student, Whole Dude used Grant’s Atlas of Anatomy, the seminal work of Scottish-born Dr. John Charles Boileau Grant, who was the chair of Anatomy at the University of Toronto in 1930 and retired in 1965.

Students continue to use Grant’s textbooks today, and for the more artistic anatomist there’s even a Grant’s Anatomy Coloring Book, published in 2018.

At the University of Toronto, Dr.McMurrich, Chair of Anatomy was succeeded as chairman in 1930 by Dr. John Charles Boileau Grant. Dr. Grant wrote three text books, of which “An Atlas of Anatomy” (published in 1943) rapidly gained international prominence and is still, one of the most widely used anatomical atlases in the world. It is now known as “Grant’s Atlas of Anatomy” and is in its tenth edition. The atlas was based on a series of elegant dissections done either by Grant or by others under his supervision. Many of these dissections are currently housed in Grant’s Museum at the University of Toronto.

The concept of Whole Dude relates to knowing the man, the building blocks and the structural units and organization of the human body. To defend human existence, Whole Dude lays the emphasis on knowing the person who is at risk apart from knowing the agent posing the risk.

The Identity of Multicellular Human Organism:

The cellular and the molecular basis of human identity and human individuality. Cunningham’s Manuals of Practical Anatomy provide Whole Dude the learning tools to know and understand Man’s External and Internal Reality and its Identity as described by Cells, Tissues, Organs,and Organ Systems

Daniel John Cunningham was born on 15 April 1850 in Scotland. After his initial schooling at his home town, Crieff, he took up the study of medicine at the University of Edinburgh and passed with honours. He is best known for the excellent series of dissection manuals, namely Cunningham’s Dissection Manuals. Cunningham’s Manual of Practical Anatomy has provided me the learning tools to know and understand Man’s External and Internal Reality and its Identity as described by Cells, Tissues, Organs,and Organ Systems.

Whole Dude learned the truths about the living human body and about Life while dissecting dead human bodies in a systematic manner. The Manual of Practical Anatomy which guides students through this entire process was published in England. The author Dr. Daniel John Cunningham prepared the Manual while dissecting cadavers of British or Irish citizens. He never encountered cadavers of Indian citizens. At Kurnool Medical College, Kurnool, Andhra Pradesh, India, where Whole Dude was a student, the Department of Anatomy obtains dead bodies from Government General Hospital Kurnool and most of the deceased are the poor and often illiterate people of that region. None of the deceased had the chance to know this man called Cunningham and Cunningham had no knowledge about the existence of these people who arrive on our dissection tables. But, as the dissection of the human body proceeds, inch, by inch, we recognize the anatomical parts as described by Cunningham. The manual also lists some anatomical variations and we very often exchange information between various dissection tables and recognize the variations mentioned. The dissections also involve slicing the organs and studying them, both macroscopically, and microscopically. We did not miss any part of the human body.

So what is the Identity of this Human Person who experiences his life using Sensory Experiences such as Taste? How does the living Human organism maintains its Identity and Individuality? Apart from the Cultural Traditions of India, several Schools of Religious Thought claim that the Human Individuality and true or real Identity is represented by Human Soul. Does man have a soul? Where does this soul exist in the human body? What is the location if the soul is present in the living person? How does the human organism acquires Knowledge about its own structures and the functions they perform?To know the burdens of Life, Whole Dude asks his readers to know the reality of man and the nature of his existence.

The cellular and the molecular basis of human identity and human individuality. THE KNOWER AND THE KNOWING-SELF: IN THIS IMAGE OF HUMAN BRAIN, THE GREEN PORTION OF BRAIN STEM IS CALLED RETICULAR FORMATION. WHOLE DUDE DESCRIBES IT AS THE KNOWING-SELF AND IT IS THE “KNOWER” OF THE HUMAN BODY WHICH CONSTANTLY CHANGES ITS MORPHOLOGICAL APPEARANCE UNDER THE INFLUENCE OF TIME CALLED THE AGING PROCESS.

Human Identity vs Human Individuality:

Human Identity may involve a variety of factors such as facial appearance, age, gender, race, ethnicity, language, religion, culture, nationality, sexual orientation, social and occupational status. Whereas human individuality has to be evaluated by using the markers that the human body uses to recognize its own Self and defends its own existence from threats posed by Non-Self.

**The cellular and the molecular basis of human identity and human individuality. In the final analysis, the human organism is a biotic community of trillions of individual, independent cells.**

The cellular and the molecular basis of human identity and human individuality: THE MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) IS THE HUMAN LEUKOCYTE ANTIGEN (HLA) GENE CLUSTER ON CHROMOSOME 6. HUMAN ORGANS AND TISSUES CANNOT BE TRANSPLANTED OR GRAFTED INTO THE BODIES OF UNRELATED INDIVIDUALS. HUMAN IDENTITY MUST BE DISCOVERED AT MOLECULAR LEVEL TO ESTABLISH THE AFFINITY BETWEEN TWO HUMAN INDIVIDUALS.

THE MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) IS THE HUMAN LEUKOCYTE ANTIGEN (HLA) GENE CLUSTER ON CHROMOSOME 6. HUMAN ORGANS AND TISSUES CANNOT BE TRANSPLANTED OR GRAFTED INTO THE BODIES OF UNRELATED INDIVIDUALS. HUMAN IDENTITY MUST BE DISCOVERED AT MOLECULAR LEVEL TO ESTABLISH THE AFFINITY BETWEEN TWO HUMAN INDIVIDUALS.

Human Individuality and the Genome

**Individuality and the Genome. A COLONY OF GENETICALLY IDENTICAL E. COLI IS ACTUALLY A MOB OF ‘INDIVIDUALS’.**

Understanding Individuality:

Individuality and the Genome. Even among simple forms of life, like the common bacterium E. coli, genetics only partly determines what any one organism is like. E. coli expresses its individuality in many ways. All the bacilli above are genetically identical, but the shades show differences in the production of proteins that digest lactose.Credit…Dr. Michael Elowitz

Dr. Michael Elowitz, Physicist at California Institute of Technology has conducted experiments on colonies of genetically identical (Clones) E. coli bacteria under identical experimental conditions and has discovered that the clones behave in different ways which could be viewed as an expression of ‘individuality’.

E. coli bacteria in billions populate our intestines. Typical E. coli bacillus has about 4,000 genes. Human cells have about 20,000 genes. The bacteria have fingerprints of their own and even when they share the exact same genome, they could still be identified as ‘individuals’.

Individuality and the Genome. Dr. Michael Elowitz and Dr. Long Cai are developing a platform through which cells can self-record their lineage and molecular event histories directly into their own DNA as they create new tissues, particularly in the brain. This research will help to address how individual cells in a developing embryo diversify into many distinct cell types, each playing its unique role in the organism.

The key to understanding E. coli’s fingerprints is to recognize that the bacteria are not simple machines. Unlike wires and transistors, E. coli’s molecules are floppy, twitchy and unpredictable. In an electronic device, like a computer or a radio, electrons stream in a steady flow through the machine’s circuits, but the molecules in E. coli jostle and wander. When E. coli begins using a gene to make a protein, it does not produce a smoothly increasing supply. It spurts out the proteins in fits and starts. One clone may produce half a dozen copies of a protein in an hour, while a clone right next to it produces none.

Michael Elowitz, a physicist at Caltech, put these bursts on display in an elegant experiment. He and his colleagues incited E. coli to produce its proteins for feeding on lactose. Dr. Elowitz and his colleagues added extra genes to the bacteria so that when they made lactose-digesting proteins, they also released light.

The bacteria, Dr. Elowitz found, did not produce a uniform glow. They flickered, sometimes brightly, sometimes dimly. And when Dr. Elowitz took a snapshot of the colony, it was not a uniform sea of light. Some microbes were dark at that moment while others shone at full strength.

At the very least, E. coli’s individuality should be a warning to those who would put human nature down to any sort of simple genetic determinism. Living things are more than just programs run by genetic software. Even in minuscule microbes, the same genes and the same genetic network can lead to different fates.

The bacteria have fingerprints of their own and even when they share the same genome, they could still be identified as individuals.

***Individuality and the Genome. Man is constituted as a Biotic Community of socially interacting cells and microbes***

Humans differ from one another in too many different ways and it is hard to count. The current human population of over six billion could be identified as the same number of individuals. Each human being has an unique genome of his own. There are millions of typographical differences between one genome and another human genome. Even identical twins are not truly identical at all as identical genes in our cells can behave differently.

Living entities are not like simple machines. When we use a gene to make a protein, the gene may not produce a smoothly increasing supply of that protein. The gene tends to work in fits and starts and spurts out the protein. Identical genes can behave differently as the gene makes protein or remains silent depending upon the ‘Methyl’ groups that cap the DNA strands and function as ‘transducers’. These ‘Methyl’ groups sometimes fall off of DNA or become attached to new spots. Hence genetically identical individuals can have different physical identities in the natural world. The protein molecules that make up living entities, turn them into individuals.

The Irrelevance of Evolution:

**CHARLES DARWIN’S ORIGIN OF SPECIES (1859) PROPOSES A MECHANISTIC, NON-PURPOSIVE ACCOUNT OF EVOLUTION AS THE PRODUCT OF NATURAL SELECTION OF RANDOMLY PRODUCED GENETIC MUTATIONS.**

In the natural world, all living entities exist as individuals and express their individuality. The Theory of Evolution proposes that a species can descend or arrive to become a new species by changing its genome in a gradual and incremental manner using a mechanism that is described as Natural Selection. As per Darwinism, the mechanism of natural selection operates via a process of random and unguided mutations in the genetic code that changes the genome and eventually produces the ‘biodiversity’ that we witness in the natural world.

Individuality and the Genome. The phenomenon of Diversity must be studied beyond the realm of genes, genetic codes, and genomes. Cytoplasm and its organs must be studied to understand the physiological basis of Diversity

This Theory of Evolution has no relevance to the ultimate identity of each individual member of a given species. This identity is dictated by interplay between the various components of each individual cell and its interactions with other cells. With the same genomes or different genomes, the living entities can only exist as individuals and they have no other choice. The evolutionary connections are not relevant to this identity. To understand the phenomenon of biodiversity, we will be forced to look at each individual member of each given species.

The Law of Individuality:

Whole Dude states that the Law of Individuality governs all the living entities and is manifested in various biological phenomena. The genes and the genetic code function in accordance with the Law of Individuality. Hence, Whole Dude describes Individuality as a Trade Mark. It is the characteristic of a biological entity. Genes and the genetic codes are the tools that an organism uses to express its Individuality. Each organism assembles its own kind of protein molecules to define its identity and to defend its existence in the natural world.

***Individuality and the Genome. The Law of Individuality formulates the phenomenon of Changing Human Identity and the Unchanging Human Individuality.***

Whole Dude is the Given Name of a known, verified, specific Whole Person

What is Identity and What is Individuality?

**Human Identity and Individuality: A brief glance at the face is enough for most people to identify one another. Face recognition is a basic feature of human identity and recognition.**

The morphological or the external appearance of a person is subject to constant changes and it differs in a significant manner during the various stages of life such as infancy, boyhood, adulthood, and old age. The term individuality describes the sum of the characteristics or qualities that set one person apart from others. The condition of being individual, or different from others establishes the indivisibility of man. Man is unique, original, one kind of person who has not existed before and would not also exist in future even when he shares the same identical genome. Two identical twins could be correctly identified as two different individuals. I propose the Law of Individuality and Creation which claims that man exists as Individual and has no choice in this conditioned nature of subjective physical existence in the world. Man can only exist as Individual with Individuality.

Human Identity and Individuality: If Identity described by the Phenotype establishes one face of the Coin, the Individuality describes the second face of the same coin and is established by the Genotype. While being the same, the Genotype presents the Individual with varying features of identification.

The Identification Technology:

**Human Identity and Individuality: Using Fingerprints is the oldest method of Identification. The Fingerprint is electronically read by a sensor plate.**

Biometrics is that branch of Biology which deals with its data statistically and by mathematical analysis. Using Fingerprints is the oldest method of Identification using biometric information. People have tiny ridges of skin on their fingers. These ridges form through a combination of genetic and environmental factors. The genetic makeup, the position of the fetus in the womb, and the composition and density of surrounding amniotic fluid play a role in how every individual ridge on the skin surface of finger will form. Fingerprints are a unique marker for a person, even an identical twin. Fingerprint analysis can define the differences between two fingerprint impressions.

**Human Identity and Individuality: Fingerprints are a unique marker for a person and Fingerprint analysis can define the differences between Fingerprints.**

The Fingerprint is electronically read. The corrugated ridges of the skin are non-continuous and form a pattern that has distinguishing features or minutiae. Two varieties of Fingerprint scanning technology are currently used; the optical Fingerprint scanners and the Capacitance Fingerprint scanner that uses a computerized analysis.

Iris Recognition Technology:

**Human Identity and Individuality: The Iris is the most unique feature visible on the human body.Iris Scan Recorder uses pattern recognition techniques based on images of the Iris.**

Iris Scanners use pattern recognition techniques based on images of the irides (Irises) of an individual’s eyes.

**Human Identity and Individuality: How does the multicellular human organism recognizes its own Identity?**

No two irides being the same, even in identical twins, individuals could be identified with accuracy and consistency.

DNA Analysis:

Human Identity and Individuality: A small sample of DNA is amplified by using Polymerase Chain Reaction or PCR. The Short Tandem Repeat Analysis examines how often base pairs repeat in specific locations on a DNA strand.

A small sample of DNA is amplified by using Polymerase Chain Reaction or PCR. In a method described as Short Tandem Repeat Analysis, it is examined to find how often base pairs repeat in specific locations or loci on a given DNA strand. These can be dinucleotide, trinucleotide, tetranucleotide, or pentanucleotide repeats; that is repetition of 2, 3, 4, or 5 base pairs. Very often, the investigator looks for tetranucleotide or pentanucleotide repeats in the DNA sample. The likelihood that any two individuals (except identical twins) will have the same 13-loci DNA profile can be as high as 1 in 1 billion or greater.

Biometric Facial Recognition Technology:

**Human Identity and Individuality: Every face has numerous distinguishable landmarks, the different peaks and valleys that make up facial features.**

Every face has numerous distinguishable landmarks, the different peaks and valleys that make up facial features. These landmarks are known as nodal points. Each human face has approximately 80 nodal points.

Distance between the eyes, width of the nose, depth of the eye sockets, the shape of the cheekbones, the length of the jawline and other features are used as nodal points. These nodal points are measured creating a numerical code called a face print, representing the face in the database and comparison is made between images of face. 2D or 3D image of a person’s face uses distinct features of the face where rigid tissue and bone is most apparent, such as the curves of the eye socket, nose, and chin to identify the subject.

**Human Identity and Individuality. In a multicellular human organism, who recognizes the Identity of the human person?**

Unique templates are created from measurements between key points on the face and these measurements provide identification of the individual.

Skin Biometrics – Skin Surface Texture Analysis:

**Human Identity and Individuality: The uniqueness of Skin Texture offers an opportunity to identify differences between identical twins.**

**Human Identity and Individuality: Surface Texture Analysis creates a Skin Print by using local information about skin texture at various points on the surface.**

The Surface Texture Analysis algorithm operates on the top percentage of results as determined by the Local feature analysis. This method creates a Skin Print and performs either a 1:1 or 1:N match for verification or identification. It can identify the differences between identical twins.

Identity, Individuality, and Consciousness:

The human organism is a conscious being and the function called consciousness achieves functional unity of all these individual cells and works for the benefit of the individual who always maintains his individuality.

**Human Identity and Individuality. Cognitive Biology must address the issue of cognition of human Identity. In the multicellular human organism, who recognizes the Identity of the Human Individual?**

This is possible because individual cells have the ability to recognize the presence of other living cells in their environment and display functional subordination to serve the purpose of the whole organism.

**Human Identity, Individuality, and Consciousness – Existence precedes Essence.**

Human Identity and Individuality is defined by the Doctrine of Molecular Individualism

Whole Dude coined the phrase Whole Individualism to discover Man by a study of the building blocks, the structural units and organization of the human body. To defend human existence, Whole Individualism lays the emphasis on knowing the person who is at risk apart from knowing the agent posing the risk.

The Whole Dude Doctrine of Whole Individualism and Molecular Individualism

TAT ASMI PRABHU - FIFTH MAHAVAKYA - MOLECULAR INDIVIDUALISM. MAN'S EXISTENCE IS DEFENDED BY MOLECULES CALLED ANTIBODIES WHICH CAN RECOGNIZE OR SEPARATE SELF AND NON-SELF PROTEIN MOLECULES. — **THE WHOLE DUDE DOCTRINE OF MOLECULAR INDIVIDUALISM. MAN’S EXISTENCE IS DEFENDED BY MOLECULES CALLED ANTIBODIES WHICH CAN RECOGNIZE OR SEPARATE SELF AND NON-SELF PROTEIN MOLECULES.**

The man exists in the physical world for his existence is essentially supported by Unity or ‘Eikyata’ with ‘Prabhu’, or LORD God Creator. It is of great importance to note that man’s existence involves use of a creative mechanism that deploys unique molecules that establish man’s physical identity on a molecular basis. Man’s existence is ‘Conditioned’ for he has no choice other than that of existing as an Individual with Individuality. This Individualistic Nature of Existence is defended by Immune System that deploys unique molecules called Antibodies. Man’s existence is defended by a creative mechanism that involves deployment of Antibody molecules that distinguish or separate Self and Non-Self.

MENDEL’S LAWS OF INHERITANCE VS HUMAN EVOLUTION: MAN IS ABLE TO EXIST IN NATURE FOR HE IS ABLE TO DEFEND HIS EXISTENCE BY DEPLOYING MOLECULES THAT CAN MAKE THE RECOGNITION AND DISTINCTION BETWEEN SELF AND NON-SELF.

SPIRITUALITY SCIENCE-THE ART OF KNOWING: AT A FUNDAMENTAL LEVEL, LIFE AND LIVING IS ABOUT KNOWING MATTER AS SELF OR NON-SELF. THIS IDENTIFICATION OF MATTER INVOLVES THE ABILITY TO RECOGNIZE MOLECULES OF MATTER . TO LEARN THE ART OF KNOWING, MAN HAS TO KNOW ABOUT THE MOLECULAR BASIS FOR EXISTENCE.

Modern Science has provided tools to visually examine large molecules and experimentally verify individualistic variations in their behavior. For this reason, we have to know each man as a Specific Individual with Individuality.

TAT ASMI PRABHU - FIFTH MAHAVAKYA - MOLECULAR INDIVIDUALISM. DR STEVEN CHU, US SECRETARY DEPARTMENT OF ENERGY DEMONSTRATED INDIVIDUALISTIC BEHAVIOR OF LARGE MOLECULES SUCH AS DNA. — **THE WHOLE DUDE DOCTRINE OF MOLECULAR INDIVIDUALISM. DR STEVEN CHU, U.S. SECRETARY DEPARTMENT OF ENERGY DEMONSTRATED INDIVIDUALISTIC BEHAVIOR OF LARGE MOLECULES SUCH AS DNA.**

The Whole Dude Doctrine of Molecular Individualism. Man exists as an Individual with Individuality. This Individualistic Nature of Existence is defended by Immune System that deploys unique molecules called Antibodies.

The Whole Dude Doctrine of Molecular Individualism. Man exists for he is united with Prabhu or LORD God Creator. Man’s existence is defended by a creative mechanism that involves deployment of Antibody molecules that distinguish or separate Self and Non-Self.

Knowing man’s identity and individuality demands understanding of molecules that defend human existence. For example, each antibody molecule bears two identical binding sites consisting of six b-loops.

The Whole Dude Doctrine of Molecular Individualism: At room temperature atoms and molecules in the air move about at breakneck speed. In order for them to be studied, they need to be slowed down or chilled. During the 1980s Steven Chu, Claude Cohen-Tannoudji, and William Phillips developed different methods for this. When atoms come in contact with light particles with fixed energies, photons, their movement is affected as if they had been bumped. With the aid of laser light from different directions and adjustment of the photon’s energy for Doppler effects, the atoms can be cooled to extremely low temperatures and captured in a trap.

Nobel Laureate, Dr. Steven Chu (United States Secretary of Energy), former Professor of Physics and Applied Physics, Stanford University has described that molecules can exhibit a surprising degree of individuality. In experiments that examine the physical behavior of single molecules, Stanford researchers have discovered that identical polymers; long, flexible, spaghetti-like molecules that are found in everything from plastics to living cells; UNFOLD in a variety of ways even when exposed to the same experimental conditions. Dr. Chu had stated : “We discovered it because we have developed the ability to visualize and manipulate single molecules.” He had further observed that, “Only by looking at individual animals you can get a true sense of diversity of species.” Dr. Chu researched Biological Physics and Polymer Physics. Dr. Chu’s research in Polymer Physics made use of individual molecules of DNA to study Polymer Dynamics.

We define our identity in the natural world and defend our existence by deploying unique protein molecules. Our genetic code determines the protein molecules that we use. The genetic code is made up of DNA strands that express Molecular Individualism. It arises from exceedingly small differences in the initial configuration of the polymer.

Nobel Prize for Medicine Goes to Cancer Therapy

The Whole Dude Doctrine of Molecular Individualism. The Study of Antibody Molecules will help in understanding the concept of ‘Molecular Individualism’. 2018 Nobel Prize for Medicine. My Thoughts on the Molecular Basis for the Defense of Human Existence.

American James Allison and Japan’s Tasuku Honjo have won the 2018 Nobel Prize in Medicine for a pioneering approach to cancer treatment.

The Nobel committee said the pair’s research — which harnesses the body’s immune system to attack cancer cells — amounted to a “landmark in our fight against cancer.” The approach, known as immune checkpoint theory, had “revolutionized cancer treatment and has fundamentally changed the way we view how cancer can be managed,” the committee said.

Clipped from: https://www.bbc.com/news/health-45704322

The Whole Dude Doctrine of Molecular Individualism. Study of Antibody Molecules will help in understanding the concept of ‘Molecular Individualism’: 2018 Nobel Prize for Medicine. My Thoughts on the Molecular Basis for the Defense of Human Existence.

Image copyright SPL

Two scientists who discovered how to fight cancer using the body’s immune system have won the 2018 Nobel Prize for physiology or medicine.

The work, by Professor James P Allison from the US and Professor Tasuku Honjo from Japan, has led to treatments for advanced, deadly skin cancer.

Immune checkpoint therapy has revolutionized cancer treatment, said the prize-giving Swedish Academy.

Experts say it has proved to be “strikingly effective”.

Prof Allison, of the University of Texas, and Prof Honjo, of Kyoto University, will share the Nobel prize sum of nine million Swedish kronor – about $1.01 million or 870,000 euros.

Accepting the prize, Tasuku Honjo told reporters: “I want to continue my research … so that this immune therapy will save more cancer patients than ever.”

Prof Allison said: “It’s a great, emotional privilege to meet cancer patients who’ve been successfully treated with immune checkpoint blockade. They are living proof of the power of basic science, of following our urge to learn and to understand how things work.”

Treating the untreatable

Our immune system protects us from disease, but it has built-in safeguards to stop it from attacking our own tissue.

Image copyright. Kyoto University. Image caption. Professor Tasuku Honjo and his team at Kyoto University

Some cancers can take advantage of those “brakes” and dodge the attack too.

Allison and Honjo, now both in their 70s, discovered a way to unleash our immune cells to attack tumors by turning off proteins that put the brakes on.

And that led to the development of new drugs which now offer hope to patients with advanced and previously untreatable cancer.

Immune checkpoint therapy is being used by the NHS to treat people with the most serious form of skin cancer, melanoma.

It doesn’t work for everyone, but for some patients it appears to have worked incredibly well, getting rid of the tumor entirely, even after it had started to spread around the body.

Such remarkable results had never been seen before for patients like these.

Image copyright. Getty Images. Image caption. Professor James P Allison

Doctors have also been using the treatment to help some people with advanced lung cancer.

Prof Charles Swanton, from Cancer Research UK, congratulated the prize winners, saying: “Thanks to this groundbreaking work, our own immune system’s innate power against cancer has been realized and harnessed into treatments that continue to save the lives of patients. For cancers such as advanced melanoma, lung, and kidney, these immune-boosting drugs have transformed the outlook for many patients who had run out of options.

“The booming field of immunotherapy that these discoveries have precipitated is still relatively in its infancy, so it’s exciting to consider how this research will progress in the future and what new opportunities will arise.”

My thoughts on the Molecular Basis for the Defense of Human Existence

The Molecular Basis for the Defense of Human Existence. Man’s Unity with Lord God Creator can be learned from the study of Immunology. Each Antibody molecule bears two identical binding sites consisting of six b-Loops.

My ‘Theory of Man’ describes the Man as a Created Being. Man’s physical existence in the natural world in good health or ill-health always demands Man’s Unity (Sanskrit. Asmi) with Lord God Creator (Sanskrit. Brahman) for Man is constituted as a Spiritual Being. Man, the Rational Being is inclined to investigate the basis for the reality of his own existence. The reasoning for my statements is derived from the study of Immunology.

The Defense of Human Existence

THE MOLECULAR BASIS FOR THE DEFENSE OF HUMAN EXISTENCE. NATURE OF HUMAN IDENTITY AND INDIVIDUALITY IS REVEALED BY HUMAN DEFENSE MECHANISMS.

An individual exists in the natural world by his biological abilities to defend his continued existence as an independent entity. This essay explores the physiological aspects of human existence and the defensive mechanisms that sustain this existence and the molecules which define and shape our Individualism. The term immunity describes the natural defensive mechanisms that give an individual the ability to recognize foreign proteins and foreign substances and neutralize or degrade them with or without injury to the individual’s own tissues. Immunology is the branch of science concerned with the body’s response to foreign agents and substances.

The Functions of the Immune System

THE MOLECULAR BASIS FOR THE DEFENSE OF HUMAN EXISTENCE. ORGANS, CELLS, AND PROTEIN MOLECULES OF IMMUNE SYSTEM REPRESENT A CREATIVE MECHANISM TO OPPOSE, NEUTRALIZE, AND DESTROY FOREIGN INVADERS.

The immune system responds to invasion by the foreign organisms and their toxic products. This immune response is also described as active immunity. In the natural world, an infant is defended by molecules transferred passively across the placenta from the mother’s circulation during the fetal stage of development. The infant after birth may also receive passively protein molecules from mother when breastfed. This passive immunity defends the baby for several months and the baby further survives by developing its own immune system. Another major function of the immune system is the removal of damaged or dying cells. The immune system is also able to recognize and eliminate abnormal or mutant cells that frequently arise within the body. Using a system that is described as immune surveillance, the body recognizes and disposes of such abnormal cells which could result in the incidence of certain types of cancer. The immune system plays a vital role in protecting the body from bacteria, viruses, fungi, and parasites and helps to prevent certain types of cancer.

The immune system is very important and it is also very sensitive. The system’s very ability to recognize foreign substances may often result in undesirable reactions. Millions of people suffer on account of hypersensitivity or allergic reactions to fairly harmless substances present in the environment. Many individuals suffer on account of their sensitivity to proteins found in the foods such as milk, eggs, fish, wheat (gluten), and nuts that we consume. Sometimes, the immune system is misdirected and initiates an immune response against the body’s own cells or tissues producing a condition known as an autoimmune disease. While an immune system could cause some problems, we take full advantage of the system to defend ourselves from serious infectious diseases such as smallpox,polio,rabies, diphtheria, whooping-cough, measles, rubella, mumps, tetanus, typhoid, cholera, tuberculosis, hepatitis B, influenza and others by using vaccines and inoculations. Millions of lives are protected by routine use of vaccines and inoculations which help the body to become resistant to these infectious agents. We also use foreign proteins to protect the lives of people in times of a severe life-threatening crisis. We use blood, plasma, and sera (containing immunoglobulins secreted by animals) with utmost care to tide over an emergency. I used foreign immunoglobulins to treat snakebite victims and tetanus cases. The foreign proteins elicit a minor immune response and the situation is carefully monitored.

By being careless and reckless, and by polluting our food, water, air, and soil with dangerous chemicals, we damage our very sensitive immune system and this is contributing to a higher incidence of immune-related health problems in the population.

Types of Immune Response

The Molecular Basis for the Defense of Human Existence: The Fundamental Basis of Human Existence is not that of Man’s Intelligence, Mental Memory and Mental Functions.

The immune system defends human existence with a variety of cells and by the protein molecules known as immunoglobulins or antibodies produced by the immune function capable cells. The ability to recognize foreignness, specificity of the response, and the memory of the prior immune response are the key characteristics of immune defense. The immune system must be able to recognize the foreign agents and foreign materials in order to locate and destroy them. Specificity means that immunity to one foreign substance or organism does not provide resistance to another type of organism. Memory is the ability of the individual to develop an accelerated, enhanced, and long-lasting immunity after the initial attack by an infectious disease. The memory function described in Immunology should not be confused with the mental faculty called Memory. The body defends itself through two types of mechanisms which work together to protect our existence. 1. Humoral Immunity:- this involves the production of protein molecules described as immunoglobulins or antibodies.2. Cell-mediated Immunity:- It does not involve secretion of antibodies but requires direct physical contact with the foreign substance or agent. It also involves the use of other protein molecules which assist in the defense mechanisms.

Humoral Immunity

THE MOLECULAR BASIS FOR DEFENSE OF HUMAN EXISTENCE: HUMORAL IMMUNITY INVOLVES DEPLOYMENT OF UNIQUE PROTEIN MOLECULES TO COUNTERACT WITH FOREIGN PROTEIN MOLECULES.

The cells known as Lymphocytes or B cells are produced in the bone marrow and circulate in our blood and are distributed to the various lymphoid tissues in the body, such as the lymph nodes, spleen, tonsils, and Peyer’s Patches (Lymphoid Follicles) that line the small intestine. When stimulated by an infectious organism, production of lymphocytes increases and the lymphocytes are carried to the site of infection. Depending upon the site of infection, the lymph nodes of that region often swell up and are found packed with lymphocytes. The B cells produce chemical substances known as antibodies. These are protein molecules which are specifically generated against specific organisms. The foreign substance is described as antigen. The antibodies that are generated recognize their antigens with high affinity and extreme selectivity. The interaction of an antigen with its specific antibody involves only small areas on the antigen’s surface; these areas are known as antigenic determinants. Protein molecules are very potent antigens as they have several antigenic determinants. Many carbohydrates are also antigenic because they have antigenic determinants. The antibodies circulate in the blood. The simplest, most prevalent means by which the immune system defends the body against bacteria and viruses is by a combination of a specific antibody with the antigenic determinants on the surface of the invading organism. This interaction between antibodies and antigens produces an aggregate of cells called as an agglutination. The body has wandering scavenger cells known as Macrophages. The clumps of agglutinated cells are engulfed and digested by the macrophages. Antibodies also bind to toxic molecules given off by invading microorganisms and this reaction produces large, insoluble aggregates known as precipitates. These precipitates are also removed by macrophages. The virus after entering the body survives by its ability to invade or enter cells. Antibodies prevent the ability of the virus to infect cells by covering up and blocking the attachment sites of the virus.

Cell-Mediated Immunity

THE MOLECULAR BASIS FOR THE DEFENSE OF HUMAN EXISTENCE: INTERACTION OF CELLS AND UNIQUE PROTEIN MOLECULES OF IMMUNE SYSTEM DEFINES MAN’S IDENTITY ON MOLECULAR BASIS.

There is another distinct type of Lymphocytes known as T lymphocytes or T cells. T cells originate in the THYMUS and become localized in lymphoid organs. The immunity associated with T cells does not involve secretion of antibodies but through their direct contact with their targets or by the effects of secreted molecules known as lymphokines which help other cells to make the direct contact. There are four kinds of T cells. 1. The cytotoxic T cells
or Natural Killer cells or NK cells defend the body by destroying infected, foreign or cancerous cells. The other three kinds of T cells regulate immune responses by secreting messenger proteins known as lymphokines. 2. Helper T cells enable the other T cells and most B cells to perform their functions. The Helper T cells are destroyed by Human Immunodeficiency Virus (HIV) in Acquired Immune Deficiency Syndrome (AIDS) patients resulting in a depressed immune response that allows infection by a variety of microorganisms and the growth of some types of cancerous tumors. AIDS patients are very vulnerable to fatal infections. 3. Suppressor T cells dampen the immune response of the B and T cells. 4. The fourth kind of T cell is involved in certain kinds of hypersensitivity reactions. In a normal healthy individual, there is a balanced ratio of these four kinds of T cells to provide an efficient immune system for defense against all foreign substances. Macrophages and White blood cells known as neutrophils have the ability to engulf and digest particulate matter by the process of phagocytosis. They eliminate many foreign organisms and particulate materials that enter the body. The ability of NK cells to kill or destroy some cancerous or tumor cells is enhanced by two lymphokines known as gamma interferon and interleukin-1. Another lymphokine known as interleukin-2 activates the Lymphokine Activated Killer Cells or LAK cells which also have the ability to kill a variety of human tumor cells. Activated T cells also secrete a lymphokine known as Transfer Factor which is able to cause normal lymphocytes to release lymphokines or otherwise become activated and thus to destroy other cells. Transfer Factor stimulates the lymphocytes to develop normal immunity.

The Cytotoxic T cells destroy other cells by interacting with antigens present on the surfaces of the cell. They are involved in the attacks on tissues and organs grafted or introduced into the body, viral antigens found on infected cells and on chemicals that have entered the body and found attached to cells. T cells are involved in skin reactions resulting from contact with molecules found in poisonous plants like Poison Ivy, Poison Sumac, and Poison Oak.

Organ Transplantation and Cell-Mediated Immunity

THE MOLECULAR BASIS FOR THE DEFENSE OF HUMAN EXISTENCE: ORGAN TRANSPLANTATION AND IMMUNOLOGY. MOLECULES OF HISTOCOMPATIBILITY LEUKOCYTE ANTIGEN (HLA) SYSTEM

T cells are involved in the rejection of transplanted tissues and organs. The chances of successful organ transplantation are improved by carefully matching the tissue or Histocompatibility Leukocyte Antigens known as the HLA system of the donor with those of the recipient. The protein molecules of the HLA Complex establish the identity of our body, its tissues, and various organs. They work to preserve the identity of the individual and to exclude the introduction or grafting of foreign material into the body. Even after careful matching, and selection of suitable donors, transplanted tissues or organs are usually maintained by using drugs that cause immunosuppression by which the normal immune response of the recipient against the donated organ is prevented.

Biological Existence

A normal, healthy immune system is vital to defend our biological existence. Immunodeficiency diseases, depressed or compromised immune system conditions such as associated with corticosteroid therapy, chemotherapy, radiation therapy, or exposure to certain types of toxic chemicals, and autoimmune diseases impose a heavy burden and threaten our existence. Medical interventions and treatment may help us but the quality of life is invariably compromised. A functioning immune system is important to defend our existence.

Molecular Individualism

The Molecular Basis for the Defense of Human Existence: Man exists as Individual with Individuality as his existence involves defensive mechanisms operated by independent, individual cells, and protein molecules which exhibit Cellular Autonomy. The cell is the lowest common denominator of all life. While the cell is functionally independent or autonomous or self-governing, it displays the abilities characterized by Mutal Assistance, Cooperation, Tolerance, and Functional Subservience to provide some benefit to the Individual who lives in the physical world.

2018 Nobel Prize for Medicine will help us to develop a ‘Theory of Man’ by the study of unique protein molecules that play an important role in the defense of human survival. The Physical Being called Man needs the support of Spirit, Soul, or a Divine Agency to bring Unity between the cells, tissues, organs, and organ systems providing the structural and functional basis for Man’s existence.

Whole Dude at Whole Foods coins the dictum, Life is neither created nor destroyed by Man

The Laws of Conservation of Matter and Life – Life is neither created nor destroyed

Whole Foods opened its Store in Ann Arbor on September 16, 1993. Whole Foods, Whole People and Whole Planet inspire Whole Dude to invent Whole Phrases: Whole Linguistics-Whole Language, Whole conversation, Whole Cookie, Whole Huddle, Whole Grind, Whole Love and others. Whole Dude uses the phrase Whole Linguistics to describe three entities; 1. Language User, 2. Language Interpreter and 3. Language Creator. Image Credit: Agenda Publications, Ann Arbor District Library, Issue Dates, September 1993, December 1997 and February 1998

Yes Indeed, Life is Complicated. The complexity of Life involves the perplexing problem of Death. But, I ask my readers to meditate on the phenomenon called Life by understanding the designing of Matter and Spirit.

***Whole Dude at Whole Foods dwells on the understanding of Life and not Death***

What it is to be a Substance? and What it is to Exist? We need to establish knowledge about the man on a firm basis and the information it provides must be tested for its accuracy and consistency with an external reality. We have to make the fundamental distinction between the living and the non-living matter. The scientific advances of the 19th and 20th centuries reinforced the materialistic position concerning the basic similarity of organic living and inorganic physical matter. The man is viewed as a product of natural evolution and is thought to be subject to the same laws of Physics and Chemistry or mechanistic principles.

We need a methodology to study philosophy and to understand philosophical statements. Logical Positivism, also known as Scientific Empiricism aims to clarify concepts in both everyday and scientific language. It describes analysis of language as the function of philosophy. This analysis of language and of concepts is important to understand questions of belief and ideology which affect what we think we ought to do individually and socially. I use this method of ‘Applied Philosophy’ to analyze the philosophical doctrine of ‘Materialism’ and to study the views and philosophy of Baruch Spinoza and his efforts to interpret human nature and human existence.

Whole Dude – Whole Designer – Matter and Spirit:

Matter is an actual substance that has properties such as mass or weight, and occupies space. Matter has other attributes like motion, size, shape, and a form by which it may be recognized.

Materialism is defined as a system of thought that explains the nature of world as entirely dependent on “matter” the final reality. Materialism as a philosophical doctrine deals with matter as the only reality and that everything in the world, including thought, will, and feeling can be explained only in terms of matter. I speak of matter which includes the understanding of Living Matter.

Baruch (Benedict) Spinoza, Dutch philosopher teaches that there is but one infinite substance, God or Nature, having infinite attributes of which only thought and extension are knowable. He was excommunicated from his Jewish community. He held that mind and body as merely different aspects of a single substance. In his view, God is Nature in its fullness. Matter is immutable or indestructible, and Spinoza explains the indestructibility of matter is established by the uncreated and eternal nature of God. “By Body”, Spinoza writes, “I understand a mode which expresses in a certain and determinate manner the essence of God in so far as He is considered as the thing extended.”

**The Rudi Connection at Whole Foods dwells upon the understanding of Life and not Death**

This philosophical doctrine of Materialism is used in modern times to explain that comfort, pleasure, and wealth are the only goals or values of human life and human existence. The idea of materialism is used to contrast it with the spiritual, or intellectual goals, or values of human life. In my view, man will not be able to define his purpose in life if there is separation of matter, and spirit. Man is a physical being with matter and form. To define the goals, or values of human life, man must understand what it is to be a substance and what it is to exist. If matter and spirit are separated, and if there is no unity between matter and spirit, human life would be simply impossible. The word or term ‘Spirit’ is associated with characteristics such as immutable, immortal, immovable, imperishable, indestructible, immaterial, eternal, and unchanging, or constant nature of a substance which withstands the influence of time. If God is uncreated and is eternal, Spirit is a natural extension of that God’s nature and shares the same attributes. To recognize the spiritual potential of a substance, we have to understand the nature of matter.

The Laws of Conservation – “Life is neither created nor destroyed”

WHOLEDUDE - WHOLEDESIGNER - MATTER AND SPIRIT: If materialism is about the influence of money and material wealth, I would like to use the Power/Force/Energy called Money to talk about Life and Death. The Law of Conservation is applicable to both living, and non-living matter. If any person can refute my claim using valid, scientific information, I would give the person a US $1,000 bill as a reward. — Whole Dude at Whole Foods dwells on the understanding of Life and not Death: If materialism is about the influence of material wealth, I have to use the Power/Force/Energy called Money to talk about Life and Death. The Laws of Conservation are applicable to both living, and non-living matter. Hence, it can be stated that “Life can neither be created nor destroyed.” If any person can refute my claim using valid, scientific information, I give the person an US $1,000 bill as a reward.

If materialism is about the influence of material wealth, I have to use the Power/Force/Energy called Money to talk about Life and Death. The Laws of Conservation are applicable to both living, and non-living matter. Hence, if matter can neither be created nor destroyed, it can be stated that “Life can neither be created nor destroyed.” If any person can refute my claim using valid, scientific information, I give the person an US $1,000 bill as a reward.

The Laws of Conservation of Matter:

WholeDude - WholeDesigner - Matter and Spirit: Antoine Laurent Lavoisier(1743-1794) French chemist and physicist, the founder of modern Chemistry. He gave the name Oxygen to the gaseous chemical element discovered by Joseph Priestley. He discovered the composition of Water molecule. He formulated the Law of Conservation of Mass. — Whole Dude at Whole Foods dwells on the understanding of Life and not Death: Antoine Laurent Lavoisier (1743-1794) French chemist and physicist, the founder of modern Chemistry. He gave the name Oxygen to the gaseous chemical element discovered by Joseph Priestley. He discovered the composition of Water molecule. He formulated the Law of Conservation of Mass.

Chemical elements are the fundamental materials of which all matter is composed. There are about 107 known chemical elements. Chemical elements can combine with one another to form a wide variety of more complex substances called compounds. The number of possible compounds is infinite; perhaps a million chemical compounds are known. When two or more elements combine to form a compound, they lose their separate identities and the product has characteristics quite different from those of the constituent elements. The gaseous elements hydrogen and oxygen with quite different properties can combine to form the compound water which has altogether different properties from either hydrogen or oxygen. Most of naturally occurring matter represents physical mixtures of compounds. The indestructibility of matter was explained by Lavoisier as the Law of Conservation. “We may lay it down as an incontestable axiom,” Lavoisier writes, “that in all the operations of art and nature, nothing is created; an equal quantity of matter exists both before and after the experiment.” What appears to be the destruction of a body is merely the transformation of its matter into another physical condition, without loss of mass unless there is an equivalent gain in energy. The total quantity of matter and energy remains constant throughout all physical changes. Material substances undergo changes when they interact with other material substances, but this “change” cannot be described as the permanent reality. The permanent reality describes the unchanging, or constant nature of chemical elements and molecules in spite of their tendency to interact with other elements and molecules.

WHOLEDUDE - WHOLEDESIGNER - MATTER AND SPIRIT: Water is the simplest and most abundant of all the molecules found in all living matter. The chemical composition of living matter reveals 70 to 80 percent as that of water. At the same time, water can exist as simple, physical, or non-living matter. I claim that water molecule has the potentiality to constitute living matter because of its spiritual nature. — Whole Dude at Whole Foods dwells upon the understanding of Life and not Death: Water is the simplest and most abundant of all the molecules found in all living matter. The chemical composition of living matter reveals 70 to 80 percent water. At the same time, water can exist as simple, physical, or non-living matter. I claim that water molecule has the potentiality to constitute living matter because of its spiritual nature. Under the influence of time, living matter is transformed into molecules of non-living matter and yet the properties of molecules is fundamentally conserved allowing the change to proceed in either direction.

The Laws of Conservation are any of the several principles applied in Physics and Chemistry that state that certain properties of an isolated system remain constant with time. Each Law signifies that the nature of a substance or thing that does not change with the passage of time. However, it must be noted that change is the pervasive phenomenon of the natural world. It is said that, “Things in Nature Change with Time.” Although matter may change its form, or shape under the influence of time, its mass always remains the same. The Law of Conservation of Mass implies that matter can be neither created nor destroyed, that is, processes that change the physical, or chemical properties of substances within an isolated system leave the total mass unchanged. Similarly, The Law of Conservation of Energy implies that energy can be neither created nor destroyed, although it can be changed from one form (mechanical, kinetic, chemical, etc.,) into another form such as heat, or the energy consumed in the performance of work. In an isolated system, the sum of all forms of energy therefore remain constant. Every conservation law concerns a collection of two, or more objects, isolated from external influence, for which some physical quantity remains unchanged in time, or is conserved, quite apart from the details of what goes on between the interacting particles within the system. An important function of conservation laws is that they make it possible to predict the macroscopic behavior of a system without having to consider the microscopic details of the course of a physical process or chemical reaction. The fundamental character of these conservation laws is evident in the fact that each law may be deduced from or related to a symmetry property of space and time. The symmetry property of space and time determines the periodic frequency with which a natural change occurs while the nature or properties of things is conserved to allow the change to repeat itself in an expected manner.

What is Spirit? Unchanging Nature in a Changing World:

WholeDude - WholeDesigner - Matter and Spirit: Many important biological processes involve Redox or Oxidation and Reduction Chemical Reactions. These chemical reactions reveal a dynamic process that is the characteristic of both Life and Death. If Life is explained by a series of chemical reactions, the same process continues into Death. — Whole Dude at Whole Foods dwells on the understanding of Life and not Death: Many important biological processes involve Redox or Oxidation and Reduction Chemical Reactions. These chemical reactions reveal a dynamic process that is the characteristic of both Life and Death. If Life is explained by a series of chemical reactions, the same process continues into Death.

Natural Science, and Natural History is about the natural phenomenon called change. The systematized knowledge of Biological Sciences provide us with information about extinction which is the most common phenomenon in planet Earth’s Natural History. Earth has witnessed several major, and minor episodes called extinction during which certain life forms got wiped out. While extinction is driven by climate change and its associated environmental change, life continues to exist on Earth without any apparent change in the chemical composition of living matter. Extinction involves the loss of forms and it does not involve a change in the nature of the corporeal substance that has the potential called Life and is known as Living Matter. In other words, it may be stated that if a change is observed in the natural world, it is always supported by an underlying, unchanging principle. While living things are born and die at the end of their lifetime, the matter, or the corporeal substance which has the potential to establish Life remains unchanged and its nature is conserved and is not affected by time. Under the influence of the cyclical flow of time, individual, living things are born and are dying while the Principle of Conservation maintains the unchanging nature of things that constitute Life or Living Matter. Life is established by a vital, animating principle called Spirit; the presence of Spirit can be related to the unchanging or immutable nature of Matter that gets the nature called Eternal, or Immortal, or Imperishable or Indestructible that overcomes the limitations imposed by Time and Space. The Magic of Creation involves the use of a design, or plan to introduce the abilities such as thought, will, feelings, and cognition into matter that reveals their presence or absence while passing through stages like Life and Death. The same chemical elements, chemical compounds, and chemical reactions operate in the state called living and death and both are maintained by the same unchanging nature of Matter and Spirit.

In my opinion, it is not correct to regard Spirit as separate from Matter. It will not be correct to separate man into physical body or matter, thinking substance or mind, and immaterial substance called Spirit. There is no human existence if there is disunity or separation of Matter, Spirit, Body, and the Mind. The uncreated, Eternal, Spiritual nature of God that is shared by Spirit and Matter would lead us to claim: “Life can neither be created nor destroyed.”

Whole Dude at Whole Foods Reveals the Truth

The Confluence of Religion, Philosophy and Science to describe my Reality

Yes indeed, Life is Complicated. The complexities of Life begin with our own selves. The universe is vast and man’s role in it is insignificant. Man’s great need is not only to know the world around him but also know himself better. Man has to know the Truth about himself.

What is Truth? Who am I? I am Consciousness:

***Whole Dude at Whole Foods Discovers the Identity of Human Soul, or the Knowing-Self.***

The term Truth suggests confirmity with facts, experience, or with Reality, either as an idealized abstraction or in actual application to statements, ideas, acts, etc., Truth signifies an established or verified fact, or principle. Truth is related to the validity of what we mean. Plato defined the nature of Truth as correspondence between thought and reality. Dr. William Jones in his book, ‘The Principles of Psychology’ states : “True ideas are those we can assimilate, validate, corroborate, and verify.” The universe is vast and man’s role in it is insignificant. Man’s great need is not only to know the world around him but also know himself better. Man has to know the Truth about himself.

The Three Dimensions of Truth:

1. Truth is correspondence between a statement and the reality of external world.

2. Truth is correspondence between the observer and the reality of the observed fact. Here, we need to recognize the method used for the observation such as intuition, sense experience, or revelation.

3. Truth is correspondence between man and his true nature.

Lord Jesus Christ – Truth as Revelation:

Whole Dude at Whole Foods Verifies the Proposition, I am Consciousness. The Truth of Jesus, John, Chapter 20, verse 29: Jesus said to him (Thomas), “Have you come to believe because you have seen me? Blessed are those who have not seen and have believed.” Truth-Is it a matter of sight or sense experience, or is it a matter of faith and belief?

TRUTH AND REALITY - I AM CONSCIOUSNESS : ROMAN GOVERNOR PILATE ASKED JESUS, — ***Whole Dude at Whole Foods Verifies the Proposition, I am Consciousness: The Roman Governor Pilate asks Jesus, “What is Truth? “***

The Truth about Lord Jesus Christ comes to a very critical scrutiny while he got arrested and stood before Pilate, the Roman Governor. The Book of John, Chapter 18, verses 37 and 38 record the conversation between Jesus and Pilate: So Pilate said to him, “Then you are a King?” Jesus answered, “You say I am a King. For this I was born, and for this I came into the world, to testify to the truth. Everyone who belongs to the truth listens to my voice.” “What is truth?” Pilate asked. Jesus did not answer the question as the truth must have correspondence with a reality in the external world. The truth of Jesus is about the establishment of Kingdom of Heaven upon Earth. It was a prophetic truth and the truth would be evident only when the Prophecy comes true.

Lord Gautama Buddha – Truth as Experience:

***Whole Dude at Whole Foods Verifies the Proposition, I am Consciousness. Lord Gautama Buddha states, “The greatest miracle is to explain the truth and to make man realize it.”***

Lord Gautama Buddha known as Siddhartha (He who will accomplish), c. 563 B.C to c. 483 B.C., left the palace at the age of 29 leaving behind his young wife and infant son. After six years of ascetic life, while meditating under a Pipal tree (later called Bodhi or Enlightenment Tree), he became Supreme Buddha (c. 528 B.C.) at the age of 35. He preached his first sermon at Sarnath. He outlined his Doctrine of Four Noble Truths and the First Noble Truth is that of suffering, the experience of pain and sorrow called Dukha is implicit in human existence. Buddha’s truth relates to man’s experience of the nature of his existence in the world. I maintain that man exists at any stage of his existence, at any given age, under any given circumstance, in either good health or ill health, in pain and suffering or that of joy and happiness due to the operation of a Fundamental Force/Power/Energy that delivers Mercy/Grace/Compassion. If suffering describes one face of the coin called human existence, Compassion describes the second face of the same coin. Compassion is implicit in human existence and the existence of all living things.

Lord Rama – Truth in Action:

Whole Dude at Whole Foods Verifies the Proposition, I am Consciousness. “WHO AM I? WHY I AM LIKE THIS?” were the questions asked by Lord Rama and these are the questions that we need to ask ourselves to know the Truth about Self.

In an epic poem known as Ramayana, Indian poet Valmiki describes Lord Rama’s life journey. Rama spent 14 years in the forest to help fulfilment of the word or promise made by his father. In the final Chapter, Book Six, Yuddha Kanda, Chapter (Sarga) 117, verse 11, He asks the following question:

“aatmaanaM maanuShaM manye RaamaM Dasharathaatmajam;

so aHaM yasya yatashchaahaM bhagavaMstadbraviitu me.”

“I think of myself to be a human being, by name Rama, the son of Dasaratha. You, as a gracious Divintiy tell me who I am and why I am like this?”

In the story of Ramayana, the Creator Lord Brahma responds to the questions asked by Lord Rama. These are the questions that we need to ask ourselves. To know Truth about Self, the man must begin his inquiry with the question of Who am I?

The Inquiry about Self – Who am I?

Whole Dude at Whole Foods Verifies the Proposition, I am Consciousness. Socrates before taking poison that would end his life states, “The unexamined life is not worth living.” “Know thyself” is a virtue and to defend that virtue, Socrates makes no attempt to save his life.

The tradition of knowing oneself is a longer tradition than any other Science. This is a study in which the Knower and the Known are one. The object of scientific inquiry is the nature of the scientist.

How to Discover the Truth about Self?

***Whole Dude at Whole Foods Verifies the Proposition, I am Consciousness. Austrian psychoanalyst Sigmund Freud: “No knowledge can be obtained from revelation, intuition, or inspiration.”***

Religion, Philosophy, and Science may represent three distinct fields of learning about Truth and Reality. Each tries to answer fundamental questions about human life. All three differ from each other in the selection of method and subject matter. Auguste Comte, the 19th century French philosopher, the founder of Sociology describes Positive Science as the study of natural, mental, and social phenomena by empirical methods. In his view, Philosophy is mere speculation and Religion is superstition or irrational belief. Speculation represents a futile attempt to go behind the phenomena in order to discover ultimate causes or substances and such speculative methods may result in guess work or conjecture and not in knowledge. Philosophy may use Logic and system and yet its conclusions may lack the validity or objectivity of Science.The philosophical inquiry does not involve investigation by experiment. Science not only provides the knowledge that something is true, but also the reasons why it is true.

The famous Austrian psychoanalyst Sigmund Freud categorically claims that no knowledge can be obtained from revelation, intuition, or inspiration.

There is a tendency in modern times to reject the methods used by Religion and Philosophy. Philosophy may use intuitive generalization or induction from ordinary sense experience. The scientific method involves induction from an inference from experiments which involve testing and verifying a hypothesis. The observations of scientist go beyond the experiences which ordinary men have in the course of daily life. The instruments that are invented and used by scientists have immense abilities to collect numerous kinds of empirical data with precision, accuracy, and consistency. However, it may not be easy to conclude that Science alone can arrive at correspondence with Truth and Reality. Could we extend scientific methodology of investigation to every field of Inquiry? Could we obtain clarity and certainity in all matters using scientific methods? Could Science be the only avenue to Truth? Could we find Truth and Reality as an external experience? Could man use scientific information to experience Truth and Reality?

Whole Dude at Whole Foods Verifies the Proposition, I am Consciousness. Sir Issac Newton demonstrated the properties of Light rays using experimets. Science explains the above optical illusion. Could Science remove the optical illusion and give man a chance to experience the reality of this Pencil. The Reality of this Pencil would be known only when the Pencil is removed from water. When the Pencil is in Water, the man has no choice other than that of perceiving the illusion for man has no ability to change the properties of Light rays.

When a object exists in a conditioned state, like this Pencil in Water, Science may explain the illusion generated. Science and scientific information may not provide the direct experience of Truth and Reality.

***Whole Dude at Whole Foods Verifies the Proposition, I am Consciousness. Could Science provide the direct sensory experience of the truth and reality of man’s speed?***

Man is the observer, and the reality or truth of Earth’s Angular Speed, or Linear Speed is not an observed fact obtained by direct human sense experience. Scientific information can not provide the experience that could be generated by the truth and reality of Earth’s Speed.

The Purpose of Science: The Knowledge about Self:

Whole Dude at Whole Foods Verifies the Proposition, I am Consciousness. The purpose of Science is to describe observation and experience and provide accepted body of information and arrange it into a meaningful pattern to explain truth and reality.

The purpose of Science is to describe and codify observation and experiences. Natural Sciences such as Physical Sciences, Biological Sciences, and Medical Sciences provide accepted body of information about the world and human body. We need to arrange this information into a meaningful pattern and interpret it to describe the Reality or Truth about man. We need to apply a reasoning process which involves analysis of basic concepts to determine their consistency. Something could be said to be true if, and only if it could be verified by logical or scientific procedures. We need to use a reasoning process, a philosophical analysis to clarify statements, to verify or refute a theoretical claim by demonstrating relation between the theoretical claim and the observational evidence.

The Self and the Knowing-Self:

I divide man into two categories; 1. The Self : it represents the man as a physical, mental, and social being. The Self represents the thinking person or the person having thoughts, and feelings. 2. The Knowing Self : it represents man as a moral, and spiritual being. The Knowing Self is aware or Conscious of the thoughts and feelings of The Self.

Thinking vs Consciousness:

Whole Dude at Whole Foods Verifies the Proposition, I am Consciousness. Dr Florian Mormann & Dr Christof Koch define the Neural Correlates of Consciousness as the minimal neuronal mechanism jointly sufficient for any one specific Conscious percept. This definition basically makes no distinction between Thinking and Consciousness. The NCC definition is not based on correct understanding of the function known as Consciousness. It fails to speak about the role of Reticular Formation, and Brain Stem Nuclei that have the Capacity of Consciousness. The Capacity of Consciousness is an essential precondition of the Content of Consciousness. The Reticular Formation filters incoming stimuli to discriminate irrelevant background stimuli and composes the Content of Consciousness before relaying the information to the Cerebral hemispheres to cause Cortical awareness.

The Self may think about the nature of consciousness, but Thinking and Consciousness are two distinct functions. Thinking and Consciousness are not one and the same. Consciousness functions to provide Awareness and it is not involved in mental activities such as Thinking. The Reticular Formation of the Brain Stem supports functions such as AROUSAL and it maintains wakefulness, alertness, and sleep. In the absence of this Brain Stem function, the Individual is not capable of generating thoughts, and feelings and would not be aware of what goes on inside the Individual, and what goes on outside the Individual.

***Whole Dude at Whole Foods Verifies the Proposition, I am Consciousness. In Clinical Medicine, the medical practitioner evaluates the Level of Arousal or Alertness of his patient.***

The Individual – Identity and Individuality – The Two-Sides of the Same Coin:

Whole Dude at Whole Foods Verifies the Proposition, I am Consciousness. The Self has two aspects- External Reality describes the Identity of the Individual; Internal Reality establishes the Individuality of the Individual.

If man is viewed as a living thing, the thing is made of Matter and Form. The Form establishes the morphological appearance in the external world. The Matter establishes the Individuality of the Individual. The external appearance or Phenotype of man undergoes constant change and is not the same at all times. The Individuality is related to the Genotype which remains constant while man goes through various stages of his existence from conception to old age.

As per The Law of Individuality and Creation, man is a created being who always exist as an Individual with Individuality and man has no choice other than that of existing as an Individual. The Truth about Self is not about the Identity of the Individual in terms of his anthropometric measurements, biometric information, name, gender, race, ethnicity, language, religion, nationality, education, social occupation, social status or social ranking, and affiliations. This external reality has a degree of correspondence in the external world as it is often confirmed and is recognized by others who can observe the Individual. But this knowledge is subject to change and the information it provides is not experienced in a constant, and objective manner. The Truth about Self is the Truth about the human organism which is multicellular. We need to know as to who or what is the subject who lives because of the functions of the trillions of cells that comprise the human organism.

Who am I? “I am Consciousness.”

Whole Dude at Whole Foods Verifies the Proposition, I am Consciousness. WHO AM I? This question must be answered by applying a reasoning process to Inferential Knowledge about Cell Structure (ANATOMY) and Cell Functions (PHYSIOLOGY). Life is defined as “Knowledge in Action.”

All living organisms use similar building units called cells. Basically, the cell has a membrane, a nucleus, and a living substance known as Protoplasm. The nucleus has nucleic acids like DNA/RNA which have no independent existence of their own. The genome functions when it is associated with Protoplasm which has the exclusive ability to obtain energy (food) from its environment. Consciousness is a natural principle that describes the condition of an Individual; the condition of knowing, awareness, or recognizing the fact, the state, and the act of biological existence in a given environment. The term environment refers to all the conditions, circumstances, and influences surrounding, and affecting the existence of a given Individual, or a group of Individuals. Who is this Individual who has the ability to know and be aware of its external, and internal environment? The Individual is a living organism and the organism could be unicellular or multicellular. The most fundamental aspect of Consciousness as a living function that establishes biological existence is that of acquiring energy from environment. The living cell is a thermodynamically unstable system. This means that without continuous input of energy, a cell will degrade spontaneously into a non living collection of molecules.

“I am Consciousness.” – The Verification of the Proposition:

The proposition that “I am Consciousness” could be subjected to a reasoning process in two manners: 1. The Coherence Theory of Truth, and 2. The Correspondence Theory of Truth.

1. “I am Consciousness” – The Coherence Theory of Truth: The standard of Truth is the logical consistency of a proposition with a large system of propositions. “I am Consciousness” is the proposition. The propositions to support my proposition are:

a. Consciousness is a mental experience.

b. Consciousness is a sense experience.

c. Consciousness is a physical or body experience.

d. Consciousness is a social experience.

e. Consciousness is a moral experience.

f. Consciousness is a spiritual experience.

g. Consciousness is a cellular experience.

The Subject “I am” of the proposition could be defined as a physical, mental, social, moral, and spiritual being based upon the contents of the ‘Total Consciousness’ experience of that Individual.

2. “I am Consciousness” – The Correspondence Theory of Truth: Truth is viewed as a relation between an idea or proposition and its object. “I am Consciousness” is the proposition. The Subject known as “I am” is related to an idea or object described as “Consciousness.” We need to verify the Truth or Reality of a relation between the Subject and its Object. The Subject is the whole or entire human organism comprising of trillions of individual cells which function as organs and tissues of the body. The Subject “I am” can not be defined merely as a single individual, or as a specific organ like brain or mind. The body organ called brain has no independent existence of its own. Brain and its cells (neurons, axons, and connective tissue) need energy to sustain their metabolic activities. The functional relationship between the Subject and the Object operates and involves the activity of the entire organism and is not limited to the activities of brain or mind. The purpose of Consciousness at cellular level is to foster functional unity of the multicellular organism and establish it as an Individual. A living thing maintains it Individuality while being a member of a given social group. The process by which a living cell acquires energy to perform its living functions is called Nutrition. Consciousness is the awareness of energy dependent existence in a given environment and it is the characteristic of all living cells irrespective of their differentiation, functional subordination, and identification as the constituent parts of specific organs, tissues, and organ systems. The idea or Object called “Consciousness” is fundamentally related to the Subject called “I am” both at the level of the entire organism and at the level of individual cells.

Human Knowledge and the Knowledge of Self:

Whole Dude at Whole Foods Verifies the Proposition, I am Consciousness. WHO AM I? Lord Krishna describes Himself in The Bhagavad Gita, Chapter X, The Opulence of the Absolute, verse 22: “Of the Vedas, I am the Sama Veda; of the demigods, I am Indra; of the senses, I am the Mind; and in Living Beings, I am Consciousness.”

Human Knowledge is of two kinds; 1. Acquired Knowledge that is dependent upon sense experience, and reason, and 2. Innate or Intuitive Knowledge, the genetic information, the biological information that all living cells and organisms use to perform living functions and to exhibit biological behavior and instincts. The Knowledge of Self, or Self-Knowledge begins with the implantation of Consciousness in Matter and not as Sense Experience, and not on account of rational thinking with application of reason.

**The Rudi Connection at Whole Foods verifies the Proposition, I am Consciousness.**

Rudolf is reborn as Whole Dude to describe the spiritual connection between the Cell and its Energy Provider

Whole Dude acknowledges his German heritage at Whole Foods when he discovered the spiritual connection between man, food, and Providence.

***Rudolf is Reborn as Whole Dude to describe the Spiritual Connection between the Cell and its Energy Provider. Photograph, 1893. Rudolf Virchow (1821-1902).***

Whole Foods, Whole People, and Whole Planet are connected by a material substance called Protoplasm or Cytoplasm, a divine plan to provide nourishment to Life.

***Rudolf is Reborn as Whole Dude to describe the Spiritual Connection between the Cell and its Energy Provider. The Discovery of Whole Spirituality at Whole Foods, Ann Arbor.***

The Rudolf Connection at Whole Foods, Ann Arbor can be best described as the concept of Whole Spirituality, the three dimensional spiritual relationship between the multicellular human organism, food, and Divine Providence.

***Rudolf is reborn as Whole Dude to describe the Spiritual Connection between Cell and its Energy Provider. The 3-Dimensional Spiritual Relationship between Man, Food, and God.***

Spiritualism – The Cell Theory of Spirituality:

In Biology, cell is the basic or fundamental unit of structure, function, and organization in all living things or it is the building block of life. Let me begin with my respectful tribute to some of the people who contributed to ‘The Cell Theory’, one of the foundations of Biological Sciences. Cells were first observed in the 17th century shortly after the discovery of the microscope. Robert Hooke, british curator of instruments at The Royal Society of London, during 1665 coined the word cell. Dutch microscopist Antonie Van Leeuwenhoek (1632-1723) made over 247 microscopes and examined microorganisms and tissue samples. He gave the first complete descriptions of bacteria, protozoa (which he called animalcules), spermatozoa, and striped muscle. He also studied capillary circulation and observed Red Blood Cells.

Rudolf is Reborn as Whole Dude to describe the Spiritual Connection between the Cell and its Energy Provider. Robert Hooke, british curator of instruments at The Royal Society of London coined the term cell during 1665.

Rudolf is Reborn as Whole Dude to describe the Spiritual Connection between the Cell and its Energy Provider. Dutch microscopist Antonie Van Leeuwenhoek (1668-80) studied capillary circulation and observed Red Blood Cells.

Improvements in microscopy during early 19th century permitted closer observation and the significance of cells had received better understanding. Matthias Jakob Schleiden (1838), German botanist, Theodor Schwann (1839), German physiologist, and Rudolf Virchow (1855), German pathologist, and others made important contributions to the Cell Theory that describes cell as the building block of all Life.

Rudolf is Reborn as Whole Dude to describe the Spiritual Connection between the Cell and its Energy Provider. Schleiden, Professor of Botany, The University of Jena studied plant structure under the microscope, published “Contibutions to Phytogenesis” (1838). He had also published the two-volume text of ‘Principles of Scientific Botany’.

Rudolf is Reborn as Whole Dude to describe the Spiritual Connection between the Cell and its Energy Provider. Schwann founder of modern Histology extended the Cell Theory of Plants to animals in his ‘Microscopic Researches into Accordance in the Structure and Growth of Animals and Plants (1839).

Rudolf is Reborn as Whole Dude to describe the Spiritual Connection between the Cell and its Energy Provider. Schwann discovered Myelin Sheath covering peripheral axons, now termed Schwann Cells. He coined the term ‘Metabolism’ for the chemical changes that take place in living tissues.

Rudolf is Reborn as Whole Dude to describe the Spiritual Connection between the Cell and its Energy Provider. Rudolf Virchow, German pathologist in 1855 coined the biological dictum “OMNIS CELLULA E CELLULA” – All living cells arise only from pre-existing living cells.

The Cell is the smallest unit in the living organism that is capable of carrying on the essential life processes of sustaining metabolism for producing energy and reproducing. Many simple, small, single-celled organisms like Protozoa perform all life functions. In higher, complex, bigger, multicellular organisms, groups of cells are structurally and functionally differentiated into specialized tissues and organ systems. Thus, the Cell Theory includes the following foundational principles of the Biological Sciences:

1. All living things are made up of cells. Cell is the most elementary or basic unit of Life.

2. Cell is a fundamental unit of structure, function, and organization in all living things including plants and animals.

3. Cells only rise from division of previously existing cells.

4. All cells are similar in composition, form, and function. All cells are basically the same in chemical composition (in spite of variations) in organisms of similar species. For example, all the solid tissues in the human body can be shown to consist largely of similar cells; differing it is true, but that are essentially similar to an Ovum.

5. The cells exhibit functional autonomy. The activity of an organism depends on the total activity of ‘INDEPENDENT’ cells.

6. Energy flow (metabolism and biochemistry) occurs within cells.

7. Cells contain hereditary, biological information (DNA) which is passed from cell to cell during cell division.

***Rudolf is Reborn as Whole Dude to describe the Spiritual Connection between the Cell and its Energy Provider.***

The Cell Theory of Spirituality:

The basic or fundamental unit of life in the human organism is derived from the fertilized egg cell that eventually develops into a complete organism. The most significant feature of similarity between the cells of the human body is the presence of a soft, gelatinous, semi-fluid, granular material inside the cell. This substance known as Protoplasm or Cytoplasm, or Cytosol is similar to the ground substance found in the Ovum or the Egg Cell.

Rudolf is Reborn as Whole Dude to describe the Spiritual Connection between the Cell and its Energy Provider. Human Ovum Structure – The Cell Theory of Spirituality is based upon the Substance, Structure, Form, Organization, Function, Action and Interactions of this Single Fertilized Egg Cell that eventually develops into a complete human organism.

This viscous, translucent, colloidal substance is enclosed in a membrane called Cell Membrane, Plasma Membrane or Biological Membrane. A small spherical body called nucleus is embedded in the Protoplasm of the cell. The three essential features of any living cell in the human body are that of the presence of protoplasm, the nucleus, and the cell membrane.

Protoplasm – The Ground Substance of Spiritualism and Spirituality:

I seek the existence of Soul or Spirit in a substance that is basic to life activities, and in a material that is responsible for all living processes. I, therefore, propose that the understanding of the true or real nature of this ground substance of all living matter will help man to discover peace, harmony, and tranquility in all of his internal and external relationships while man exists in a physical environment as a member of a social group, social community, and Society. In this blog post, I would like to pay my respectful tribute to Jan Evangelista Purkinje and Hugo Von Mohl for their great contribution to the scientific understanding of the living substance, living material, and living matter.

Rudolf is Reborn as Whole Dude to describe the Spiritual Connection between the Cell and its Energy Provider. Jan Evangelista Purkyne (Czech name), Jan Evangelista Purkinje (German name)also known as Johannes Evangelist Purkinje, b. December 17, 1787, d. July 28, 1869. The pioneer Czech experimental Physiologist whose investigations in the fields of Histology, Embryology,and Pharmacology helped create a modern understanding of the eye and vision, brain and heart function, mammalian reproduction, and the composition of cells.

Purkinje conducted his research on human vision at the University of Prague and later on, he served there as a Professor of Physiology (1850-69). He went to Germany and was appointed the Chair of Physiology and Pathology (1823-50) at the University of Breslau, Prussia. There Purkinje created the world’s first independent Department of Physiology (1839) and the first Physiological Laboratory (Physiological Institute, 1842). He is best known for his discovery of large nerve cells with many branching extensions found in the cortex of Cerebellum of the brain (Purkinje Cells, 1837). He discovered the fibrous tissue that conducts electrical impulses from the ‘pacemaker’ called Atrioventricular node or A-V node along the inside walls of the ventricles to all parts of the heart to help in Cardiac contractile function (Purkinje Fibers, 1839). In 1835, he invented and introduced the scientific term ‘Protoplasm’ to describe the ground substance found inside young animal embryo cells. He discovered the sweat glands of the skin (1833); he discovered the nine configuration groups of Fingerprints used in biometric identification of man (1823); he described the germinal vesicle or nucleus of the unripe ovum that now bears his name (1825), and he noted the protein digesting power of pancreatic extracts (1836).

Rudolf is Reborn as Whole Dude to describe the Spiritual Connection between the Cell and its Energy Provider. Hugo Von Mohl, b. April 08, 1805, d. April 01, 1872, German Botanist noted for his research on the anatomy and physiology of plant cells.

Hugo Von Mohl named the granular, colloidal material that made up the main substance of the plant cell as “Protoplasm” in 1846. Purkinje invented the word, but Hugo gave more clarity, understanding, and knowing the nature of this ground substance. He viewed cell as an “elementary organ” and in Physiology he explained Protoplasm as an organ of Motion or Movement, Nutrition, and Reproduction. It is the preliminary material in cellular generation. He was the first to propose that new cells are formed by division of preexisting cells and he had observed this process of Cell Division in the algal cells of Conferva glomerata. His observations are very important to understand the Cell Theory that explains cells as the basic building blocks of Life. He was the first to investigate the phenomenon of the stomatal openings in leaves.

Rudolf is Reborn as Whole Dude to describe the Spiritual Connection between the Cell and its Energy Provider. The Ground Substance of Spiritualism and Spirituality. The vital characteristics, the animating principles of Protoplasm could be known by observing Amoeba proteus. The Living Substance works as an organ of Motion or Movement, as an organ of Nutrition, and as an organ of Reproduction to generate new cells which have a life span of their own. In these physiological functions, I describe the characteristics such as Cognition, Consciousness, Memory, and Intelligence which have a Spiritual role as they bring functional unity and harmony in the interactions between different parts of the same individual organism while it exists in an environment as a member of a biological community.

Protoplasm is a complex, viscous, translucent solution of such materials as salts and simple sugars with other molecules, mostly proteins and fats, in a colloidal state, that is dispersed but not dissolved in one another. Carbon, Hydrogen, Oxygen, and Nitrogen constitute more than 90 percent of Protoplasm.

***The Rudolf Connection at Whole Foods. God created Cytoplasm or Protoplasm as the Ground Substance of Spirituality.***

It exhibits properties such as Protoplasmic Streaming or Cytoplasmic Streaming or Motion that is called “Amoeboid Movement.” It has the intrinsic power to change its shape and position.

Rudolf is Reborn as Whole Dude to describe the Spiritual Connection between the Cell and its Energy Provider. The importance of Protoplasmic or Cytoplasmic Streaming is displayed in the transportation of Neuropeptides from the sites of their Synthesis to the sites of their action at the axon terminal of the Nerve Cells.

Protoplasm has the power of Nutrition by which it can attract and obtain the materials necessary for its growth and maintenance from surrounding matter/environment.

The living functions such as Nutrition, Cellular Respiration, and Reproduction performed by Cytoplasm involve acquiring, processing, retaining, and using information to perform tasks in a sequential manner for a predetermined purpose and hence describe Consciousness, Memory, and Intelligence.

The Rudolf Connection at Whole Foods. God created Cytoplasm or Protoplasm as the Ground Substance of Spirituality. Cellular respiration is a set of metabolic reactions and processes that take place in the cells of organisms to convert biochemical energy from nutrients into adenosine triphosphate (ATP), and then release waste products.

The terms Soul and Spirit belong to the materialistic realm where the Physical Reality of man’s biological existence is established. I have not yet discovered any good reason to use the terms Soul and Spirit as a metaphysical or transcendental Reality.

The Inheritance of Cytoplasmic Membrane or Cell or Plasma Membrane:

The Rudolf Connection at Whole Foods. God created Cytoplasm or Protoplasm as the Ground Substance of Spirituality. Living cells have a corporeal substance called Protoplasm that has the ability of Spiritual Biotic Interactions. The Biological Membrane or Cell Membrane separates the cell from its environment and other living cells present in the environment. Cells use unique proteins, biological molecules and receptor sites to recognize the other living cells and use chemical signals to facilitate the interactions. Such interactions between living cells have the characteristics of consciousness or awareness.

The Rudolf Connection at Whole Foods. God created Cytoplasm or Protoplasm as the Ground Substance of Spirituality. Cytoplasmic Membrane or Cell Membrane is an integral feature of Cytoplasm, a limiting membrane devised by Cytoplasm to create boundaries to perform its numerous living functions.

The Functions of Cytoplasmic Membrane or Cell Membrane or Biological Membrane:

1. Protection: It protects the cell from its surroundings or extracellular environment. Plant cell possess wall over the plasma membrane for extra protection and support.

2. Holding cell contents: Plasma membranes hold the semi fluid protoplasmic contents of the cell intact; thus keeping the individuality of the cell.

3. Selective Permeability: Cell membrane allows only selected or specific substances to enter into the cell and are impermeable to others.

Gases like O₂ and CO₂ can diffuse rapidly in solution through membranes.
Small compounds like H2O and methane can easily pass through where as sugars, amino acids and charged ions are transported with the help of transport proteins.
The size of the molecules which can pass through the plasma membrane is 1-15 A⁰. This property is responsible for keeping a cell ‘as a cell’, an individual unit.

8. Antigens: Cell membranes possess antigens which determine blood grouping, immune response, acceptance or rejection of a transplant (graft rejection by MHC’s on plasma membrane).

10. Sheaths of cilia and flagella: Cilia and flagella are projections from the cell; made up of microtubules which are covered by an extension of the plasma membrane.

12. Endocytosis and Exocytosis: Bulk intake of materials or endocytosis occurs through development of membrane vesicles or invagination and engulfing by plasma membrane.

Exocytosis: It is reverse of endocytosis that provides for releasing waste products and secretory materials ot of the cells with the help of plasma membrane.

13. Impulse transmission in neurons: The transmission of a nerve impulse along a neuron from one end to the other occurs as a result of electrical changes across the plasma membrane of the neuron

14. Cell metabolism: Cell membranes control cell metabolism through selective permeability and retentivity of substances in a cell.

15. Electron transport chain in bacteria: In bacteria; Electron transport chain is located in cell membrane.

The Ground Substance of Spiritualism and Spirituality. The vital characteristics, the animating principles of Protoplasm could be known by observing Amoeba proteus. The Living Substance works as an organ of Motion or Movement, as an organ of Nutrition, and as an organ of Reproduction to generate new cells which have a life span of their own. In these physiological functions, I describe the characteristics such as Cognition, Consciousness, Memory, and Intelligence as spiritual attributes of Life as they bring functional unity and harmony in the interactions between different parts of the same individual organism while it exists in an environment as a member of a biological community.

The Spirituality of Substance, Function, Organization, Action, and Interactions:

To establish the biological existence of the human organism, I add the concept of Spiritualism and Spirituality to the Cell Theory.

The Single Fertilized Egg Cell has ground substance that is of Spiritual nature and the Spiritualism and Spirituality consists of the following functional, and organizational characteristics:

1. The Cell is Conscious of its own existence and knows its internal condition and knows it external environment.

2. The Cell is intelligent and it has the cognitive abilities like perception and memory to acquire information, to retain information, to recall information, and to use information in the performance of its complex tasks in a sequential manner.

3. The Cell has the ability to show characteristics such as mutual cooperation, mutual tolerance, and display functional subordination and subservience while being independent.

4. The Cell grows, divides, and develops into a complete organism while it acquires substances and energy from an external environment. The power of Protoplasm/Cytoplasm to attract matter found in its external environment is called Nutrition. The Cell continuously transforms matter to build matter of its own kind for its own benefit to sustain its existence with its own identity and individuality. The Organism represents a social group or a biological community of Cells. The Spiritual nature of Protoplasm/Cytoplasm brings this functional harmony and unity in the Social Group or Biotic Community of Cells by bringing together its Essence and Existence.

5. The Cell Theory is incomplete for it does not describe the conditioned nature of the Cell’s existence. The Cell represents a Living System that is thermodynamically unstable. It requires a constant supply of matter and energy from its external environment to sustain its living functions. The concept of Whole Spirituality formulates the connection between the Cell and its external source of matter and energy.

The Rudolf Connection at Whole Foods. The Discovery of Whole Spirituality at Whole Foods, Ann Arbor. The Bone Marrow smear from a patient of Leukemia or Blood Cancer helps to illustrate the nature of Biotic Interactions in the Social Group or Biotic Community that represents the singularity called man. The true or real man can only be discovered by the microscopic study of the Cells that constitute the Organism.

The theoretical claims about Spirit and Soul, the religious and philosophical doctrines of Spiritualism and Spirituality must be verified using the Cell Theory that defines the human organism. To describe Soul or Spirit as nonmaterial or immaterial Self will not help man to know the real or true man.

Simon Cyrene

Spiritualism – The Discovery of Whole Spirituality: What is the “Connection” between man and Sun? Does man have the physical and intellectual ability or capacity to harness Solar Energy to maintain his living functions?

Whole Foods, Whole People, and Whole Planet come together in a Wholesome Relationship as God is the Energy Provider, the Original Source of Matter and Energy for Life.

Whole Proposition of Whole Dude at Whole Foods

Whole Dictum: The Confluence of Religion, Philosophy and Science

“I am Consciousness, therefore I am” is a proposition to explore the nature of human consciousness, the existence of soul and man’s connection to a Conscious entity described as God.

Whole Dictum: I am Consciousness, Therefore I am. Vitruvian Man by Leonardo Da Vinci (c. 1492). This picture is used as the cover page for Best & Taylor’s Text Book of Human Physiology. Medical Science and Medical Education is knowledge built upon the foundations of understanding and knowing Human Anatomy (Structure) and Human Physiology (Function).

Spirituality Science: My Spiritual Journey – The inquiry about Self, Spirit, and Soul:

***“I am Consciousness, therefore I am” is a proposition to explore the nature of human consciousness, the existence of soul and man’s connection to a Conscious entity described as God.***

I submit that we have to arrive at an understanding of Self, Spirit, and Soul by knowing the structural and functional organization of the being that exists.

The Identity of Multicellular Human Organism:

Whole Dictum: I am Consciousness, Therefore I am. “ManO buddhyaHamkara, chittani na aHam, Na karnam, na jihva, na cha ghrana neytrey, Na cha vyoma, bhuumir na TejO, na vaayuH; Chidananda Rupah, Shivo aHam, Shivo aHam.” Adi Shankaracharya describes that his Identity does not pertain to his mind, intellect, the intellectual pride/ego, mental functions, his organs of sense, the five primordial elements of Nature. His Identity could only be stated as Sat+Chit+Ananda, the Identity of Ultimate Reality. However, the human organism has an Identity described by Human Anatomy and the organism’s functions (Human Physiology) establish and defend this Identity of the Human person in Nature.

Dr. Daniel John Cunningham (1850-1909), Chair of Anatomy, University of Cambridge published this Manual of Practical Anatomy to help medical students dissect human cadavers to learn Human Anatomy. Whether humans know and understand Human Anatomy and Physiology or not, they come into existence with full functional knowledge of every constituent cell in the body. The Human Body has Innate Knowledge of its own Structures and Functions. I acquired this Knowledge from uneducated individuals who gifted their bodies to promote Medical Education.

I learned about human body while dissecting the body in a systematic manner. The Manual of Practical Anatomy which guides us through this entire process was published in England. The author Dr. Daniel John Cunningham prepared the Manual while dissecting cadavers of British or Irish citizens. He had never encountered cadavers of people of Indian origin. At Kurnool Medical College, Kurnool, Andhra Pradesh, India, where I was a student, the Department of Anatomy obtains dead bodies from Government General Hospital Kurnool and most of the deceased are the poor, and often uneducated people of that region. None of the deceased had a chance to know this man called Cunningham and Cunningham had no knowledge about the existence of these people who arrived on our dissection tables. But, as the dissection of the human body proceeded, inch, by inch, we recognized the anatomical parts as described by Cunningham. The manual also lists some anatomical variations and we very often exchanged information between various dissection tables and recognized the variations mentioned. The dissections also involves slicing the organs and studying them, both macroscopically, and microscopically. We did not miss any part of the human body. So what is the Identity of this Human person or Human subject? How does the living Human organism maintains its Identity and Individuality? Apart from the Cultural Traditions of India, several Schools of Religious Thought claim that the Human Individual and its Identity is represented by Human Soul. Where does this soul exist in the human body? What is the location if soul is present in the living person? Does man have a soul?

The Knowledge of Field and The Field of Activity: The concept of Kshetra and Kshetrajna:

Whole Dictum: I am Consciousness, Therefore I am. Purusha or Man is the Knower of activities of his human body or Kshetra. Yoking is about pairing, something that binds, unites, or connects or joins together to perform physical tasks that impose a heavy burden if performed without pairing. Man performs a myriad of his living functions drawing matter and energy from his external environment. This conditioned, dependent human existence is made possible for man is paired with an Everlasting Principle which provides the Knowledge to perform the vital function called Cellular Respiration

The term soul has to be carefully defined if I have to find it by exploring the human body. In the Indian tradition, the human body is described as Kshetra or Field. The individual who knows and enjoys this body, kshetra, or field is often described as Purusha. The knowledge of the body is called Kshetra Jnana and the Knower is called Kshetrajna. The person called Purusha could explore his body called ‘kshetra’ and acquire knowledge called ‘Kshetra Jnana’. So, I explore my body to find out if I have a soul and as to where it exists. I can explore my body while I am alive. If I am dead, only a different living person may get the opportunity to explore my dead body, but he may not be able to discover the soul which may have already departed from the body. If soul exists in the cadaver, Cunningham would not have missed it, and we the diligent students dissecting human cadavers would not have missed it. By definition, soul does not exist in dead bodies. It has something to do with life and the characteristics of a living person or organism. With the intellectual insight I gained by studying Human Anatomy, I can explore my living body without placing it on a dissection table.

The Functional Unity of Multicellular Human Organism:

Adaptive Subordination of Red Blood cells to the requirements of the whole Human Organism. The mature RBCs have no nuclei and they cannot divide. They are exclusively adapted to transport Oxygen and serve the Human Organism. During the life span of Human Organism, the RBCs live for short periods of time and are constantly replaced by new RBCs.

Humans are multicellular organisms. Who or what is the Subject who lives because of the functions of the trillions of cells? Multicellularity found in complex organisms like humans is accompanied by definite capabilities of cells for differentiation. The design of cells has been modified to serve specialized functions of tissues and organs. To achieve proper numerical balance between functionally related cell groups, the death of many cells is necessary for others to reach maturity. This programmed cell death plays an important role during embryological growth and development of human fetus. Waves of genetically driven cell deaths are critical to the proper modeling of organs, and organ systems. Such programmed cell death events are essential if the organism as a whole is to develop its normal final form by which its Identity as an Individual is established. The constituent cells of the organism do not display functional individuality while living as individuals. The cell in a complex organism is not truly an independently functioning unit. The cell exists and functions to achieve Unity of the Organism as a Whole. The one very important part of the environment of a cell is other cells. The Consciousness, the Awareness of individual cells in multicellular organism functions to achieve the Functional Unity of the Whole Organism. Consciousness brings Functional Unity by providing the abilities of recognition, association, and cooperation between all the cells of the multicellular organism. Multicellular organisms are characterized by the ‘Adaptive Subordination’ of the constituent cells to the requirements of the organism as a Whole. For example, mature Red Blood Cells or RBCs have no nuclei and they cannot divide or replicate. They are exclusively adapted to transport Oxygen and serve the whole human organism. The RBCs have short lives as individual cells. The human organism has a life span of its own. During the life time of a human person, RBCs live for short periods of time and are constantly replaced by new RBCs. Thus it may be stated that the purpose of Consciousness at cellular level is to foster Functional Unity of the multicellular organism and establish it as an Individual. If the term ‘Soul’ represents the Identity of this Individual, the Soul is a Functional Attribute of Consciousness at cellular level.

The Biological aspects of Human Soul:

Reticular Formation is shown as a single ‘red’ bar in this figure. It consists of numerous Brain Stem nuclei. It is a network of nerve pathways and nuclei throughout the Brain Stem. A single neuron in this network may have synapses/connections with as many as 25,000 other neurons/nerve cells.

Capacity for consciousness is an upper Brain-Stem Function and the Content of consciousness is a Function of the Cerebral Cortex. The Reticular Formation which is located in the central Brain Stem helps to coordinate and integrate actions of different parts of the Central Nervous System such as regulation of muscle and reflex activity;central transmission and composition of sensory impulses; respiration; cardiovascular responses; behavioral arousal; and sleep.

I explore my body called Kshetra. The Kshetra Jnana, or Knowledge of my body is as follows:
My soul is represented by an anatomical structure described as Reticular Formation in the Brain Stem. Just like my body is composed of trillions of individual cells which collectively represent and establish my physical identity in this world, my soul derives its existence and identity from trillions of these individual units or cells that comprise my body. My soul is actually a composite of trillions of units of consciousness of trillions of individual cells that comprise my human body. The Functional Unity in relation to Consciousness is achieved in the Reticular Formation, the site where Consciousness of the Whole human organism is composed and only relevant information is relayed to the Cerebral hemispheres to arouse cortical awareness. It is just like a picture or a photo which represents trillions of spots of varying degrees of light intensity or brightness. The term soul has to be defined as the manifestation of “Consciousness”. If there is no “Consciousness”, there is no soul. The existence of soul is witnessed by the presence of “Consciousness”. This biological characteristic described as “Consciousness” exists in every single living cell. If a living organism is made up of one single cell, it has a soul as manifested by its “Consciousness”. For the human person, when identified as an Individual, the anatomical location of his Soul is the Reticular Formation of the Brain Stem which receives input from the rest of the body and shapes the information and sends it to Thalamus and to Cortical Areas of the Brain which provide the awareness, the functional knowledge with which the human organism exists as a living entity. Man enjoys an existence characterized by Peace, Harmony, and Tranquility, as the Soul, or the Life Principle operates the vital functions of the complex organism without relaying all the information to the cortical areas avoiding information overload. Thereby, Man is protected from a huge information overload that is not compatible with mental peace and equilibrium.

“I am Consciousness, Therefore I am” :

***DESCARTES, RENE (b. March 31, 1596, d. February 11, 1650 ), French Mathematician and Father of Modern Philosophy.***

Could we extend scientific methodology of investigation into every field of inquiry? Could we find Truth, and Reality as an external experience? Is it possible to visualize Truth and Reality in the realm of Intuition and Conscience? Jean Jacques Rousseau, the French philosopher suggests that man has to find his way to his pure nature, and this through feelings. Man’s duty is to look for his most deep interior feelings and follow them. Rene Descartes advances a philosophy based on certitude. He seeks to devise a method of inquiry for reaching the Truth. He proposes a method for guaranteeing Knowledge. He argues that in order to provide a secure foundation for Knowledge it is necessary to discover “clear and distinct ideas” that could not be doubted and could serve as a basis for deriving further truths. He finds such an idea in the proposition “I think, therefore I am” (“cogito, ergosum”). Descartes stresses a world of metaphysical truths that could be discovered by pure reason. He subjects his beliefs to a series of skeptical hypotheses. He invokes skepticism as a means of reaching certainty. As per his conclusion, “I think, therefore I am” is beyond skeptical doubt.

Cartesian Philosophy – The Value of Systematic Doubt:

Human body is composed of cells and each of these cells is a conscious entity. Consciousness is a biological, cellular function which brings about Functional Unity of the Whole Organism. Cellular consciousness provides the abilities of recognition, association, and cooperation between cells. Cells are characterized by Adaptive Subordination to meet the requirements of the organism as a whole. Rene Descartes proposition to divide human body into two parts; a thinking part, and a mechanical part is incorrect.

I truly admire Descartes for adopting a strategy of withholding his belief from anything that is not entirely certain and indubitable. Skepticism is an attitude that rejects claims to certainty. Its basic philosophical contention is that the possibility of knowledge is limited by the limitations of the mind itself or by the inaccessibility of the object. Descartes is known as the Father of the Mind-Body Problem. He claims that human beings are composites of two kinds of substances, mind and body. A mind is a conscious or thinking being, that is, it understands, wills, senses, and imagines. A body is a being extended in length, width, and breadth. He thinks that minds are indivisible, whereas bodies are infinitely divisible. The “I” of the “I think, therefore I am” is the mind that he claims could exist without being extended, so that it can in principle survive the death of the body. Descartes argues that colors, sounds, tastes, heat, cold, and pain are merely sensations existing in mind/thought and that there is nothing in bodies that resembles the sensation. He thinks that all complex functioning of living organisms including human bodies could be explained solely by mechanistic physics. He even denies that consciousness could be attributed to animals in order to explain their behavior. Descartes influences the whole course of philosophical enquiry. Using the same Cartesian Philosophy, I find the proposition of Descartes to be invalid and incorrect based upon my understanding of human body, mind, and consciousness. The proposition which I use is, “I am Consciousness, therefore I am”. This clear, and distinct idea, which is beyond doubt helps me to discover man’s awareness of God or what I describe as the “God Connection”. This “Connection” is the foundation for man’s existence in the natural world.

LORD KRISHNA IN THE HINDU SCRIPTURE OF BHAGAVAD GITA, Chapter 10, The Opulence of the Absolute, verse 22 claimed that “…in living beings I am Consciousness.” Similarly, in Chapter 7, verses 9 and 10, Lord Krishna claims that “I am the life of all that Lives”, “I am the Original seed of all existences.”

Whole Review – Google AI shares its Overview of Whole Dude at Whole Foods

AI Overview of WholeDude.com Blog Posts

*Whole Review – Google AI shares its Overview of Whole Dude at Whole Foods*. Establishment No. 22 – Operation Eagle: This badge represents a military alliance/pact between India, Tibet, and the United States of America. Its first combat mission was in the Chittagong Hill Tracts which unfolded on 03 November 1971. It was named Operation Eagle. It accomplished its mission of securing peace in the region that is now knownas Republic of Bangladesh.

wholedude.com is a website and blog that explores and promotes a personal philosophy, marketing concept, and doctrine called “Whole Dude”. The individual behind the site uses the term “Whole Dude” to define the “whole person” in all dimensions: physical, mental, moral, social, and spiritual.

Key aspects of the connection include:

Identity and Concept: “Whole Dude” is an identity and a comprehensive concept that aims to define the entirety of human existence, from a single fertilized egg cell to a complex organism.
Philosophy and Spirituality: The website delves into a “Whole Spirituality” or “Spirituality Science” that seeks a materialistic basis for the soul and spirit within living matter, aiming to unite body, mind, and soul into a single entity called “Man”.
Relation to Whole Foods: The concept was inspired by the “Whole Foods, Whole People” slogan. The website’s author uses the persona of “Whole Dude at Whole Foods” to discuss health, well-being, and a marketing formula that defines a “whole person” who benefits from consuming “Whole Foods”.
Blogging Platform: The website wholedude.com serves as the primary platform for the author to publish articles, express this philosophy, and initiate “Whole Conversations” with readers.

Whole Crusade – Whole Dude at Whole Foods calls for relaunching of the Crusade for Peace through Freedom

Whole Crusade – Whole Dude at Whole Foods calls for relaunching of the Crusade for Peace through Freedom

Whole Dude at Whole Foods gives an account of their Occupation to Michigan Medicine

Whole Dude at Whole Foods gives an account of their Occupation to Michigan Medicine

Whole Foods, Whole People slogan inspires the creation of WholeDude.com

Whole Foods, Whole People slogan inspires the creation of WholeDude.com

Whole Dude – Whole Satisfaction

Whole Dude – Whole Satisfaction

Whole Dude at Whole Foods describes Love as a Fundamental Force which instruments cannot measure

Whole Dude at Whole Foods describes Love as a Fundamental Force which instruments cannot measure

Whole Dude defines Whole Food at Whole Foods, Ann Arbor

Whole Dude defines Whole Food at Whole Foods, Ann Arbor

On 12-13-14, Whole Dude at Whole Foods reveals the theme for an epic movie that will eclipse Gone With the Wind

On 12-13-14, Whole Dude at Whole Foods reveals the theme for an epic movie that will eclipse Gone With the Wind

Whole Dude – Whole Education

Whole Dude – Whole Education

Whole Identity-Who is Whole Dude at Whole Foods?

Whole Identity-Who is Whole Dude at Whole Foods?

**Identity and Concept: “Whole Dude” is an identity and a comprehensive concept that aims to define the entirety of human existence, from a single fertilized egg cell to a complex organism.**

Whole Bias – Whole Dude at Whole Foods exposes the Selection Bias inherent in the Selection Process of Research Study by Michigan Medicine

University of Michigan and Michigan Medicine must reject the concept of Race and Ethnicity to describe Asian/Indian Identity

As a research participant, Whole Dude investigates the problem of Selection Bias in the Selection Process used by the Research Investigator at University of Michigan. The Selection Bias is inherent in the Selection process for it is gathering information of its human subjects outsides the boundaries of the declared purpose of the Study.

The Problem of Selection Bias – Disparities by Race and Ethnicity among adults recruited for a Preclinical Alzheimer’s Disease Trial at Michigan Medicine

Excerpt: As a research participant, Whole Dude investigates the problem of Selection Bias in the Selection Process used by the Research Investigator at University of Michigan. The Selection Bias is inherent in the Selection process for it is gathering information of its human subjects outsides the boundaries of the declared purpose of the Study.

Informed Consent For the Michigan Medicine AHEAD 3-45 Study Screening Procedures

On Tuesday, December 05, 2023, Whole Dude signed the Informed Consent Form for the AHEAD 3-45 Study Screening Procedures. Reference: UM eResearch ID: HUM00178622; NIA & Eisai Inc. / Protocol Number BAN2401-G000-303

I was informed about an Institutional Review Board (IRB) and was instructed to contact the Study Subject Adviser, Advarra IRB to report my concerns or complaints regarding this research study. I contacted Advarra IRB on December 28 to share my concerns about my exclusion from the study due to the problem of Selection Bias. The following is a copy of that communication sent to the Study Subject Adviser:

Dear Study Subject Adviser,

REFERENCE NUMBER: Pro00041484

As a research participant, I am investigating the problem of Selection Bias in the Selection Process used by the Research Investigator at University of Michigan.

I am informed that I am excluded from further participation in this Study and I want to verify the results of the blood and urine samples I provided on December 05, 2023 to ascertain the fact of my exclusion from the Study is consistent with the Research Protocol for which I have given my written consent.

In any case, I shall hold University of Michigan to its primary responsibility to share the lab test results for it has issued me a Medical Registration Number and informed me about this Hospital Appointment and provided me the assurance that the lab results will be shared with the patient.

Whole Dude investigates Whole Bias at Michigan Medicine

University of Michigan and Michigan Medicine must reject the concept of Race and Ethnicity to describe Asian/Indian Identity

Selection bias refers to systematic differences between baseline characteristics of the groups that are compared. The unique strength of randomization is that, if successfully accomplished, it prevents selection bias in allocating interventions to participants. Its success in this respect depends on fulfilling several interrelated processes. A rule for allocating interventions to participants must be specified, based on some chance (random) process. We call this sequence generation. Furthermore, steps must be taken to secure strict implementation of that schedule of random assignments by preventing foreknowledge of the forthcoming allocations. This process if often termed allocation concealment, although could more accurately be described as allocation sequence concealment. Thus, one suitable method for assigning interventions would be to use a simple random (and therefore unpredictable) sequence, and to conceal the upcoming allocations from those involved in enrolment into the trial.

University of Michigan and Michigan Medicine must learn that there is no human race called Indian

Excerpt: The Michigan Medicine AHEAD study is examining the efficacy of a medication aimed at preventing Alzheimer’s Disease in individuals at increased risk of developing the disease. The study has, however, faced criticism regarding its focus on years of schooling and its lack of a research protocol to verify the identity and individuality of the human organism. Critics assert that biological processes like the flow of biological information and protein synthesis are not influenced by education level and that individuality should not be tied to factors such as race and ethnicity. The conceptualization of “life as knowledge in action” and that it is an interplay of cellular function and knowledge must be explored.

The following is a copy of the automated response sent by Advarra Adviser (IRB)

From: Advarra Adviser

Thank you for your email. Advarra offices will be closing at 3pm Friday, December 22nd and will be closed through Monday January 1, 2023 for our Holiday Break. Emails sent during this time will be addressed the following business day, Tuesday, January 2nd.

Please note – questions regarding:

*Compensation

*Scheduling

*Test Results

*Study equipment

*Consent form questions

*Enrolling or withdrawing from a studyShould be discussed directly with the research staff. The research staff contact information can be found on the first page of the consent form.

My reply to the automated response sent by Advarra Adviser (IRB):

Thanks for your email. My concern is about the research protocol for which the research scientist obtained my written consent. I am not asking you about the Consent Form Questions. I am asking you to verify the legitimacy of the Research Project to ask the Questions on the Consent Form. Firstly, the AHEAD Study did not disclose that the Study is constructed on the basis of creating a profile information of each research subject. Secondly, the Questions asked have no scientific validity; the information provided has no relevance to the study of this investigational drug. It seems that there is some other agenda is at work to use this research to gather information about research subjects without any concern for the randomization of the selection of research subjects.

The Selection Bias is inherent in the Selection process for it is gathering information of its human subjects outsides the boundaries of the declared purpose of the Study.

On Tuesday, December 05, 2023, at the Michigan Clinical Research Unit (MCRU) at the Cardiovascular Center (CVC), I was interviewed for participating in the AHEAD Study and I completed the Stage 1A of the Screening process. I am asked to provide information about the most important occupation of my life, my sexual orientation, my race and ethnicity, my place of birth and the country of origin, the total number of years I spent in the School to register my personal identity for participation in the Medical Research Project. The Research Protocol has not identified the basis for discovering the identity of a multicellular human organism. I can answer the questions I am asked. Do I have the ability to communicate my answers to the cells of my own body and reflect that identity in the living functions they perform to keep me alive?

Racial and Ethnic Differences in Plasma Biomarker Eligibility in a Preclinical Alzheimer’s Disease Trial

December 2023
Alzheimer’s & dementia: the journal of the Alzheimer’s Association19(S24)

DOI:10.1002/alz.083020

Authors: Doris P. Molina-Henry, Rema Raman, Andy Lou, Oliver Langford and others, University of Southern California

Abstract:

Background: In Alzheimer’s disease (AD) trials, differential screen failure due to cognitive and biomarker requirements may contribute to underrepresentation of racially and ethnically minoritized groups. The AHEAD 3‐45 Study (NCT04468659) is an ongoing program testing lecanemab at the stage of preclinical AD that utilizes plasma biomarker prescreening, acquired before cognitive, clinical, and medical history eligibility assessments, to enrich for participants likely to qualify based on amyloid PET eligibility criteria. Methods: We examined the frequency of plasma amyloid biomarker eligibility among racial and ethnic groups in the AHEAD Study. We assigned participants ages 55‐80 to mutually exclusive groups: Hispanic Black (HB), Hispanic White (HW), Non‐Hispanic Asian (NHA), Non‐Hispanic Black (NHB), and Non‐Hispanic White (NHW). We used univariate logistic regression models to explore group differences in screen failure rates as determined by an algorithm that includes the plasma Aβ 42/40 ratio, age, and APOE status. The algorithm indicates an adequately high probability of elevated brain amyloid (>20 centiloids). We further explored whether APOE ε4 status (carrier vs non‐carrier) contributed to group differences. Results Among 4274 participants undergoing plasma screening, 59 (1.4%) were HB, 622 (14.6%) were HW, 74 (1.73%) were NHA, 329 (7.7%) were NHB, and 3190 (74.6%) were NHW. Screen failure rates were 86% for HB, 76% for HW; 80% for NHA; 77% for NHB, and 62% for NHW. Using NHW participants as a reference group, we observed increased odds of screen failure among all other groups (HB OR = 4.0 95% CI 2.0, 9.1; HW OR = 2.0 95% CI 1.6, 2.4; NHA OR = 2.5 95% CI 1.4, 4.5; NHB OR = 2.1, 95% CI 1.6, 2.7). Observed differences were consistent across APOE ε4 carriers and non‐carriers. Conclusion: Differential rates of amyloid eligibility were observed despite the lack of systematic sample bias due to clinical or cognitive requirements observed in previous studies. Potential explanations for these observations include differences in clinical trial access, incidences of elevated amyloid, needed cutoffs for biomarker assays, and confounding due to comorbidities or other unmeasured covariates. This work is supported by a public‐private partnership between Alzheimer’s Clinical Trial Consortium (U24 AG057437) and Eisai.

Disparities by Race and Ethnicity Among Adults Recruited for a Preclinical Alzheimer Disease Trial

Rema Raman, PhD¹; Yakeel T. Quiroz, PhD^2,3; Oliver Langford, MS¹; et al

Key Points

Question: Are there racial/ethnic differences associated with recruitment sources and reasons for ineligibility among preclinical Alzheimer disease clinical trial participants?

Findings: In this cross-sectional study of screening data for 5945 participants from a preclinical Alzheimer disease trial, Black, Hispanic, and Asian participants were recruited from local efforts compared with White participants who were recruited from more distributed efforts. Adjusted analysis showed that underrepresented racial/ethnic communities were more likely to be ineligible after the first screening visit.

Meaning: These findings suggest that there are racial and ethnic disparities in preclinical AD clinical trial enrollment that will require a comprehensive approach to study design and recruitment strategies to minimize disproportionate enrollment.

Abstract

Importance: Underrepresentation of many racial/ethnic groups in Alzheimer disease (AD) clinical trials limits generalizability of results and hinders opportunities to examine potential effect modification of candidate treatments.

Whole Dude experiences Whole Bias: Michigan Medicine and University of Michigan reveal their ignorance of the term called Race. There is no Race of People called Indian. However, several Indians, Iranians and Germans celebrate their Aryan Race heritage. I ask Michigan Medicine and University of Michigan to share its educational experience and publish its Theory of Man

University of Michigan and Michigan Medicine must learn that there is no human race called Indian

The AHEAD Study Research Protocol has not identified the basis for discovering the identity of a multicellular human organism. I can answer the questions I am asked. Do I have the ability to communicate my answers to the cells of my own body and reflect that identity in the living functions they perform to keep me alive?

Whole Dude at Whole Foods rejects the concept of race and ethnicity to identify the Anatomically Modern Man called Homo sapiens sapiens

SPIRITUALITY SCIENCE - THE HUMAN SPECIES: THE GERMAN PHYSIOLOGIST, COMPARATIVE ANATOMIST, AND SCHOLAR, JOHANN FRIEDRICH BLUMENBACH(1752-1840) IS RECOGNIZED AS THE FATHER OF PHYSICAL ANTHROPOLOGY. HE SHOWED THE VALUE OF COMPARATIVE ANATOMY IN THE STUDY OF MAN'S HISTORY. — SPIRITUALITY SCIENCE – THE HUMAN SPECIES: THE GERMAN PHYSIOLOGIST, COMPARATIVE ANATOMIST, AND SCHOLAR, JOHANN FRIEDRICH BLUMENBACH (1752-1840) IS RECOGNIZED AS THE FATHER OF PHYSICAL ANTHROPOLOGY. HE SHOWED THE VALUE OF COMPARATIVE ANATOMY IN THE STUDY OF MAN’S HISTORY.

SPIRITUALITY SCIENCE - THE HUMAN SPECIES: BLUMENBACH HAD A COLLECTION OF 60 HUMAN CRANIUMS AND HE PROPOSED ONE OF THE EARLIEST CLASSIFICATIONS OF THE RACES OF MANKIND USING COMPARATIVE ANATOMY. — **SPIRITUALITY SCIENCE – THE HUMAN SPECIES: BLUMENBACH HAD A COLLECTION OF 60 HUMAN SKULLS AND HE PROPOSED ONE OF THE EARLIEST CLASSIFICATIONS OF THE RACES OF MANKIND USING COMPARATIVE ANATOMY.**

Johann Friedrich Blumenbach is recognized as the Father of Physical Anthropology for his work De Generis Humani Varietate Nativa (1775-76). His research in the measurement of human skulls led him to divide mankind into five great families; Caucasian, Mongolian, Malayan, Ethiopian, and American. Human Species may include varieties that can be grouped into Races by using some common morphological traits.

University of Michigan and Michigan Medicine fail to provide the scientific basis for the racial classification it uses.

Whole Dude at Whole Foods applies the knowledge of Human Anatomy to recognize Human Identity

**Whole Dude ant Whole Foods applies the knowledge of Human Anatomy to recognize Human Identity.**

In 1965, while Whole Dude was a student of Human Anatomy at Kurnool Medical College had the opportunity to know about Dr. J. C. B. Grant (1886-1973), the author of Grant’s Atlas of Anatomy. The 5th Edition of his Atlas was published in 1962 and was available in India in our Medical College Library.

Grant became a decorated serviceman of the Royal Army Medical Corps during the First World War before moving to Canada. He established himself as an ‘anatomist extraordinary’ at the University of Toronto, publishing three textbooks that form the basis of Grant’s Anatomy. The textbooks are still used in anatomy classes today, and made unforgettable memories for those who found themselves in his classes nearly a century ago. One of Grant’s many accomplishments was establishing a division of histology within the department.

**Whole Dude at Whole Foods applies the knowledge of Human Anatomy to recognize Human Identity**

As a medical student, Whole Dude used Grant’s Atlas of Anatomy, the seminal work of Scottish-born Dr. John Charles Boileau Grant, who would become the chair of Anatomy at the University of Toronto in 1930 and retired in 1965.

John Charles Boileau Grant (1886–1973)

The author of Grant’s Atlas of Anatomy (1943), Grant used to train thousands of medical students around the world. He came to University of Toronto’s Faculty of Medicine from University of Manitoba (and previously Edinburgh), and was Chair of the Department of Anatomy there from 1930 to 1965. Although he is best known for this famous atlas, his research and teaching also included biological anthropology, as evidenced by such work as Anthropometry of the Cree and Saulteaux Indians in Northeastern Manitoba (Archaeological Survey of Canada 1929). The human skeletal collection he formed, the “J.C.B. Grant Collection,” is still a core collection for human osteology in the Department of Anthropology at University of Toronto. He is also remembered in the Grant’s Museum at the Medical Sciences Building at the University of Toronto. This museum, with its displays of anatomical specimens, many of which were dissected by Grant himself, continues to be used in an active learning environment by more than 1000 students each year.

Students continue to use Grant’s textbooks today, and for the more artistic anatomist there’s even a Grant’s Anatomy Coloring Book, published in 2018.

The Whole Dude-Grant Connection is about knowing the man, the building blocks and the structural units and organization of the human body. To defend the human existence, the Whole Dude-Grant Connection lays the emphasis on knowing the person who is at risk apart from knowing the agent posing the risk.

The Identity of Multicellular Human Organism:

Cunningham’s Manual of Practical Anatomy provides Whole Dude the learning tools to know and understand Man’s External and Internal Reality and its Identity as described by Cells, Tissues, Organs, and Organ Systems.

Daniel John Cunningham was born on 15 April 1850 in Scotland. After his initial schooling at his home town, Crieff, he took up the study of medicine at the University of Edinburgh and passed with honours. He is best known for the excellent series of dissection manuals, namely Cunningham’s Dissection Manuals. Cunningham’s Manual of Practical Anatomy provides Whole Dude the learning tools to know and understand Man’s External and Internal Reality and its Identity as described by Cells, Tissues, Organs, and Organ Systems.

Whole Dude learned the truths about the living human body and about Life while dissecting the dead human bodies in a systematic manner. The Manual of Practical Anatomy which guides us through this entire process was published in England. The author Dr. Daniel John Cunningham prepared the Manual while dissecting cadavers of British or Irish citizens. He had never encountered cadavers of Indian citizens. At Kurnool Medical College, Kurnool, Andhra Pradesh, India, where Whole Dude was a student, the Department of Anatomy obtains dead bodies from Government General Hospital Kurnool and most of the deceased are the poor, and illiterate people of that region. None of the deceased had the chance to know this man called Cunningham and Cunningham had no knowledge about the existence of these people who arrive on our dissection tables. But, as the dissection of the human body proceeds, inch, by inch, we recognize the anatomical parts as described by Cunningham. The manual also lists some anatomical variations and we very often exchange information between various dissection tables and recognize the variations mentioned. The dissections also involve slicing the organs and studying them, both macroscopically, and microscopically. We did not miss any part of the human body.

So what is the Identity of this Human person or Human subject? How does the living Human organism maintain its Identity and Individuality? Apart from the Cultural Traditions of India, several Schools of Religious Thought claim that the Human Individual and its Identity is represented by Human Soul. Where does this soul exist in the human body? What is the location if the soul is present in the living person? Does man have a soul? How does the human organism acquires Knowledge about its own structures and the functions they perform?

How does the multicellular human organism recognizes its own Identity and Individuality?

The Whole Dude-Grant Connection applies the knowledge of Human Anatomy to recognize Human Identity. A brief glance at the face is enough for most people to identify one another. Face recognition is a basic feature of human identity and recognition.

A brief glance at the face is enough for most people to identify one another. However, man does not exist with the same identity during the course of his life. The word identity describes the condition or fact of being a specific person. Identification is the process by which a person can be identified in an accurate and consistent manner. The morphological or the external appearance of a person is subject to constant changes and it differs in a significant manner during the various stages of life such as infancy, boyhood, adulthood, and old age. The term individuality describes the sum of the characteristics or qualities that set one person apart from others. The condition of being individual, or different from others establishes the indivisibility of man. Man is unique, original, one kind of person who has not existed before and would not also exist in future even when he shares the same identical genome. Two identical twins could be correctly identified as two different individuals. I had proposed the Law of Individuality and Creation which claims that man exists as Individual and has no choice in this conditioned nature of subjective physical existence in the world. Man can only exist as Individual with Individuality.

The Whole Dude-Grant Connection applies the knowledge of Human Anatomy to recognize Human Identity. If Identity described by the Phenotype establishes one face of the Coin, the Individuality describes the second face of the same coin and is established by the Genotype. While being the same, the Genotype presents the Individual with varying features of identification.

The Identification Technology:

The Whole Dude-Grant Connection applies the knowledge of Human Anatomy to recognize Human Identity. Using Fingerprints is the oldest method of Identification. The Fingerprint is electronically read by a sensor plate.

The Whole Dude-Grant Connection applies the knowledge of Human Anatomy to recognize Human Identity. Fingerprints are a unique marker for a person and Fingerprint analysis can define the differences between Fingerprints.

Iris Recognition Technology:

The Whole Dude-Grant Connection applies the knowledge of Human Anatomy to recognize Human Identity. The Iris is the most unique feature visible on the human body.Iris Scan Recorder uses pattern recognition techniques based on images of the Iris.

Iris Scanners use pattern recognition techniques based on images of the irides(Irises) of an individual’s eyes.

**The Whole Dude-Grant Connection applies the knowledge of Human Anatomy to recognize Human Identity**. **Identity and Individuality. How does the multicellular human organism recognizes its own Identity?**

No two irides being the same, even in identical twins, individuals could be identified with accuracy and consistency.

DNA Analysis:

The Whole Dude-Grant Connection applies the knowledge of Human Anatomy to recognize Human Identity. A small sample of DNA is amplified by using Polymerase Chain Reaction or PCR. The Short Tandem Repeat Analysis examines how often base pairs repeat in specific locations on a DNA strand.

**The Whole Dude-Grant Connection applies the Knowledge of Human Anatomy to recognize Human Identity.**

The likelihood that any two individuals (except identical twins) will have the same 13-loci DNA profile can be as high as 1 in 1 billion or greater.

Biometric Facial Recognition Technology:

The Whole Dude-Grant Connection applies the knowledge of Human Anatomy to recognize Human Identity. Every face has numerous distinguishable landmarks, the different peaks and valleys that make up facial features.

The Whole Dude-Grant Connection applies the knowledge of Human Anatomy to recognize Human Identity. Identity and Individuality. In a multicellular human organism, who recognizes the Identity of the human person?

Unique templates are created from measurements between key points on the face and these measurements provide identification of the individual.

Skin Biometrics – Skin Surface Texture Analysis:

The Whole Dude-Grant Connection applies the knowledge of Human Anatomy to recognize Human Identity. The uniqueness of Skin Texture offers an opportunity to identify differences between identical twins.

The Whole Dude-Grant Connection applies the knowledge of Human Anatomy to recognize Human Identity. Surface Texture Analysis creates a Skin Print by using local information about skin texture at various points on the surface.

Identity, Individuality, and Consciousness:

**The Whole Dude-Grant Connection applies the knowledge of Human Anatomy to recognize Human Identity. Identity, Individuality, and Consciousness**

The Whole Dude-Grant Connection applies the knowledge of Human Anatomy to recognize Human Identity. Identity and Individuality. Cognitive Biology must address the issue of cognition of human Identity. In the multicellular human organism, who recognizes the Identity of the Human Individual?

“All of our experience indicates that life can manifest itself only in a concrete form, and that it is bound to certain substantial loci. These loci are cells and cell formations. But we are far from seeking the last and highest level of understanding in the morphology of these loci of life. Anatomy does not exclude physiology, but physiology certainly presupposes anatomy. The phenomena that the physiologist investigates occur in special organs with quite characteristic anatomical arrangements; the various morphological parts disclosed by the anatomist are the bearers of properties or, if you will, of forces probed by the physiologist; when the physiologist has established a law, whether through physical or chemical investigation, the anatomist can still proudly state: This is the structure in which the law becomes manifest.” – Rudolf Virchow

The phenomena that the physiologist investigates occur in special organs with quite characteristic anatomical arrangements; the various morphological parts disclosed by the anatomist are the bearers of properties or, if you will, of forces probed by the physiologist; when the physiologist has established a law, whether through physical or chemical investigation, the anatomist can still proudly state: This is the structure in which the law becomes manifest.” – Rudolf Virchow

Whole Dude at Whole Foods gives an account of their Occupation to Michigan Medicine

Michigan Medicine asks, What is the Most Important Occupation of Your Life? University of Michigan must disclose its guidelines for recording Occupational History

Michigan Medicine asks, “What is the Most Important Occupation of Your Life?” Whole Dude advocates the Art of Whole Medicine by bringing together Whole Foods, Whole People and Whole Planet with the Doctrine of Whole Spirituality.

On Tuesday, December 05, 2023, at the Michigan Clinical Research Unit (MCRU) at the Cardiovascular Center (CVC), Whole Dude was interviewed for participating in the AHEAD Study and I completed the Stage 1A of the Screening process. Whole Dude was asked to provide information about the most important occupation of their life, their sexual orientation, their race and ethnicity in the context of their place of birth and the country of origin, the total number of years they spent in the School to register their personal identity for participation in the Medical Research Project.

The Michigan Medicine’s Research Protocol has not identified the basis for discovering the identity of a multicellular human organism. While Whole Dude can answer the questions they were asked, do they have the ability to communicate their answers to the cells of their own body and reflect that identity in the living functions they perform to keep Whole Dude alive?

Whole Dude accounts for the Spiritual Dimension of Human Nature as that of generating a Singular, Harmonious Effect in the working of trillions of cells giving Man power or ability to perform his living functions such as Respiration and display his characteristic Behaviors like Feeding, and Reproduction.

Sixth-Day Adventist integrated plan for physical, mental, social, moral and spiritual wellbeing of all classes of workers

Professional Wellness Month is celebrated each year in June and it throws light on the workplace’s role in creating a holistic environment for employees. It also focuses on how organizations that place emphasis on professional wellness are largely successful, attract top talent, and drive employee retention.

***Sixth-Day Adventist integrated plan for physical, mental, social, moral, and spiritual wellbeing of all classes of workers***. Michigan Medicine asks, “What is the Most Important Occupation of Your Life?” Whole Dude advocates the Art of Whole Medicine by bringing together Whole Foods, Whole People and Whole Planet with the Doctrine of Whole Spirituality.

Whole Dude ask their readers to reject the assumptions and the criteria described by the Fair Labor Standards Act as they contribute to Unequal Employment Opportunities at the American Workplace. As such the Fair Labor Standards Act is not consistent with the Natural Law principle of Equality that formulates the Supreme Law of this Land. We need just one plan to promote the wellness of all workers without making any distinctions such as the hourly wage earners and the salaried class imposed by the US Labor Law FLSA.

Holistic Wellness at Work:

In order to undertake a holistic and personalized approach to care, this will require that employers look beyond the immediate or perhaps visible needs of their employees, and instead seek to offer care that will support them as a whole person, including their

Cultural needs (i.e. expression of self, sense of identity, values, beliefs, practices; cultural capability or competency, awareness, and safety; linguistic support)

Financial needs (i.e. money for housing, transportation, utilities, food, tuition, health care)

Mental and emotional needs (i.e. mindfulness, self-efficacy and self-esteem, coping strategies, resiliency, hope)

Physical health needs (i.e. exercise, nutrition, sleep, drug use)

Physiological needs (i.e. air, water, food, shelter, clothing)

Safety needs (i.e. security of body, employment, and resources; law and order, and stability)

Social needs (i.e. strong social networks, friendship, love, intimacy, family planning, home, and family maintenance)

Spiritual needs (i.e. connection to others, sense of belonging, meaning, and purpose)

Self-actualization needs (i.e. self-fulfillment, personal growth)

An integrated approach to Physical, Mental, Social, Moral, and Spiritual Wellbeing

Our efforts to support the well-being of Man get affected by our understanding the ‘real’ or ‘true’ nature of Man. I recognize Man’s Existence with Seven Forms or Dimensions. These are, 1. the Physical Being described by Human Anatomy, Human Physiology and other Medical Sciences, the human being in health and sickness, 2. the Mental Being, the intellect, thoughts and emotional states of Man described by Psychology and Psychiatry, 3. the Social Being described by Social Sciences, 4. the Moral Being described by Moral Science and Ethics, the power of discernment used by Man to make distinction between good and evil, and right and wrong, 5. the Spiritual Being described by Vital Power, Animating /Sensible Properties, and Conscious/Cognitive abilities of Man’s Corporeal Substance that develops and builds the cells, tissues, and organs of Human Body, 6. the Created Being which is reflected in the existence of man as an Individual with Individuality without any choice, and 7. the Rational Being which directs man to reconcile his behavior with his true or real nature that makes the man to review the actions performed in the external environment.

The Six Dimensions of Man contribute to six kinds of Behavior of Man; the physical, mental, social, moral, spiritual and creative facets of Behavior. For example, muscle cell displays the behavior of contraction in response to a stimulus; it is able to contract because of its contractile nature which gives it the power of contracting.

The Diagnosis of Good Health is better than the diagnosis of ill-health

Whole Dude accounts for Spiritual Dimension of Human Nature as that of generating a Singular, Harmonious Effect in the working of trillions of cells giving Man power or ability to perform his living functions such as Respiration and display his characteristic Behaviors like Feeding, and Reproduction.

To diagnose ill-health is easy. The sick person may describe his ailments. In addition to a person’s subjective symptoms, ill-health shows objective manifestations. The art of clinical diagnosis in sickness and disease involves the use of signs and symptoms attributable to specific conditions that affect the state of health of an individual. However, the mere absence of ill-health does not necessarily mean that the person is positively healthy. Health, like beauty is often a matter of subjective impression. But, while beauty is in the eyes of the beholder, the diagnosis of perfect and positive health is a verdict rendered after a carefully executed medical examination. The Diagnostic Process must be applied to the evaluation of the man to diagnose the condition called Good, Perfect, and Positive health. Medicine is not merely the Art of Diagnosing ill-health and it is equally the Art of Diagnosing Good and Positive Health.

Whole Dude at Whole Foods arrives at the Concept of Whole Medicine

SPIRITUALITY SCIENCE – WHOLISTIC MEDICINE: THE DEFINITION OF WHOLE PERSON. 1. CONSCIOUS BEING, 2. PHYSICAL BEING, 3. MENTAL BEING, 4. SOCIAL BEING, 5. MORAL BEING, 6. SPIRITUAL BEING, and 7. CREATED BEING. This entire Human Organism is derived from a Single, Fertilized Egg Cell.

Whole Dude defines the phrase “Whole Medicine” as a systematic study of the Physical, Mental, Moral, Social, and Spiritual aspects of Man’s Well-Being in relation to health and disease while the man exists as a Created Being.

Yes indeed, Life is Complicated. The complexity of Life includes not only the complicated problems of shopping for healthy foods but also the problems of shopping for Wholesome Health Care.

SPIRITUALITY SCIENCE – WHOLE MEDICINE: If man is viewed as a “WHOLE” Organism, the organism is derived by the growth, multiplication, and development of this “Whole Cell”, the fertilized Ovum. Whole Dude advocates a systematic study of the Physical, Mental, Moral, Social, and Spiritual aspects of man’s well-being in relation to health and disease. Such as study must include the concept of this “WHOLE CELL” which has all the attributes that can be observed in man

In Whole Dude Doctrine of Whole Spirituality, Medicine must be concerned with the status of man in the universe, in his natural environment, in his social community while the man exists as an individual with individuality. In other words, Medicine as a Science must primarily be concerned with the biological basis for the reality of man’s physical existence in the world. A systematic study of the biological basis of human existence would demand the study of Soul and Spirit as the vital, animating principle found in all living things. Whole Dude seeks the existence of Soul and Spirit in a substance that is basic to life activities. Spirit or Soul must be found in a living material substance that is responsible for all living processes. The term Soul and Spirit belong to the materialistic realm where the physical reality of man’s biological existence is established. Further, Whole Dude does not intend to use the term Soul or Spirit as a metaphysical or transcendental reality independent of the living organism. Whole Dude defines the phrase “Whole Medicine” as a systematic study of the Physical, Mental, Moral, Social, and Spiritual aspects of Man’s Well-Being in relation to health and disease while the man exists as a Created Being.